Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Juan A Faraldos"'
Autor:
Artemis Giannakopoulou, Sebastian Schornack, Tolga O Bozkurt, Dave Haart, Dae-Kyun Ro, Juan A Faraldos, Sophien Kamoun, Paul E O'Maille
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e107462 (2014)
Plants protect themselves against a variety of invading pathogenic organisms via sophisticated defence mechanisms. These responses include deployment of specialized antimicrobial compounds, such as phytoalexins, that rapidly accumulate at pathogen in
Externí odkaz:
https://doaj.org/article/86bf756e5e4f408ab28c5a1c19d4bfcb
Publikováno v:
Journal of phycology. 39(2)
The "red tide" organism Karenia brevis (Davis) HansenMoestrup (=Gymnodinium breve Davis) produces a mixture of brevetoxins, potent neurotoxins responsible for neurotoxic shellfish poisoning in humans and massive fish kills in the Gulf of Mexico and t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::668fe6fef905aafc656037332a973590
https://pubmed.ncbi.nlm.nih.gov/33066707
https://pubmed.ncbi.nlm.nih.gov/33066707
Publikováno v:
Plant Science. 255:29-38
Epistasis, the interaction between mutations and the genetic background, is a pervasive force in evolution that is difficult to predict yet derives from a simple principle − biological systems are interconnected. Therefore, one effect may be intima
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9388577e21d41f5a8f4fed8e10c1b44d
https://doi.org/10.1016/j.plantsci.2016.11.006
https://doi.org/10.1016/j.plantsci.2016.11.006
Artemisinin aus der Pflanze Artemisia annua ist das wirkungsvollste Arzneimittel zur Behandlung von Malaria. Die Sesquiterpen-Cyclase Amorphadien-Synthase, ein Cytochrom-abhangiges CYP450 und eine Aldehyd-Reduktase wandeln in der Pflanze Farnesyl-Dip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2808a70c1d5f0b0ed10f04b30d5baddf
https://orca.cardiff.ac.uk/id/eprint/100400/7/Demiray_et_al-2017-Angewandte_Chemie.pdf
https://orca.cardiff.ac.uk/id/eprint/100400/7/Demiray_et_al-2017-Angewandte_Chemie.pdf
Publikováno v:
MethodsX
MethodsX, Vol 1, Iss C, Pp 187-196 (2014)
MethodsX, Vol 1, Iss C, Pp 187-196 (2014)
Graphical abstract
Terpenes are the largest group of natural products with important and diverse biological roles, while of tremendous economic value as fragrances, flavours and pharmaceutical agents. Class-I terpene synthases (TPSs), the domina
Terpenes are the largest group of natural products with important and diverse biological roles, while of tremendous economic value as fragrances, flavours and pharmaceutical agents. Class-I terpene synthases (TPSs), the domina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f04f0bbda2dbabd87c8baf722769d00
http://europepmc.org/articles/PMC4472957
http://europepmc.org/articles/PMC4472957
Autor:
Juan A. Faraldos, Stefano Leoni, Rudolf Konrad Allemann, Oscar Cascón, Daniel J. Grundy, Marc W. van der Kamp
Publikováno v:
Faraldos, J A, Grundy, D J, Cascon, O, Leoni, S, Van der Kamp, M & Allemann, R K 2016, ' Enzymatic synthesis of natural (+)-aristolochene from a non-natural substrate ', Chemical Communications, vol. 52, no. 97, pp. 14027-14030 . https://doi.org/10.1039/C6CC08164A
The sesquiterpene cyclase aristolochene synthase from Penicillium roquefortii (PR-AS) has evolved to catalyse with high specificity (92%) the conversion of farnesyl diphosphate (FDP) to the bicyclic hydrocarbon (+)-aristolochene, the natural precurso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8736a0640154411912fe2c708589bb70
https://hdl.handle.net/1983/bb5d886d-e1b0-4cf1-9765-cae7eaea0092
https://hdl.handle.net/1983/bb5d886d-e1b0-4cf1-9765-cae7eaea0092
Autor:
Rudolf Konrad Allemann, Edward L. D'Antonio, Juan A. Faraldos, David W. Christianson, Marine Janvier, David E. Cane, Naeemah Al-Lami, Mengbin Chen
Publikováno v:
Biochemistry. 52:5441-5453
Aristolochene synthase, a metal-dependent sesquiterpene cyclase from Aspergillus terreus, catalyzes the ionization-dependent cyclization of farnesyl diphosphate (FPP) to form the bicyclic eremophilane (+)-aristolochene with perfect structural and ste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e36dd2fe9f68c2d0238531eecbae3f4b
https://doi.org/10.1021/bi400691v
https://doi.org/10.1021/bi400691v
Autor:
Juan A. Faraldos, Trinh-Don Nguyen, Melissa Salmon, Paul E. O'Maille, Dae-Kyun Ro, Maria Vardakou
The Andes-endemic Barnadesioideae lineage is the oldest surviving and phylogenetically basal subfamily of the Asteraceae (Compositae), a prolific group of flowering plants with world-wide distribution (∼24,000 species) marked by a rich diversity of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5593ad128cb145cbdd96532338d64b12
https://ueaeprints.uea.ac.uk/id/eprint/61001/
https://ueaeprints.uea.ac.uk/id/eprint/61001/
Despite its distance from the active site the flexible amino-terminal segment (NTS) in the β-domain of the plant sesquiterpene cyclase δ-cadinene synthase (DCS) is essential for active site closure and desolvation events during catalysis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e21a70e7e06252fe057a9541faf8e062
https://orca.cardiff.ac.uk/id/eprint/94402/3/Manu-NTS-Final-REV.pdf
https://orca.cardiff.ac.uk/id/eprint/94402/3/Manu-NTS-Final-REV.pdf
Autor:
David W. Christianson, Wayne K. W. Chou, Naeemah Al-Lami, David E. Cane, Mengbin Chen, Rudolf Konrad Allemann, Juan A. Faraldos
Aristolochene synthase (ATAS) is a high-fidelity terpenoid cyclase that converts farnesyl diphosphate exclusively into the bicyclic hydrocarbon aristolochene. Previously determined crystal structures of ATAS complexes revealed trapped active site wat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::758b914fce0e96f89f6ad634925d6363
https://orca.cardiff.ac.uk/id/eprint/93708/1/ATASwater_finalversion.docx
https://orca.cardiff.ac.uk/id/eprint/93708/1/ATASwater_finalversion.docx