Dipeptidyl peptidase IV of the Vespa velutina nigrithorax venom is recognized as a relevant allergen

Autor: Gabriela Pretre, Juan Andrés Asturias, María Teresa Lizaso, Ana Isabel Tabar

Publikováno v: Annals of Allergy, Asthma & Immunology. 129:101-105

Vespa velutina nigrithorax (VVN), typically known as the Asian yellow-legged wasp, has been one of the most significant invasive species in western Europe since 2010. Currently, VVN has become the most prevalent cause of Hymenoptera anaphylaxis in th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a631bb119ca57d3c443578320be1574c
https://doi.org/10.1016/j.anai.2022.02.018

Tolerability and surrogate efficacy parameters of a polymerized depot mixture pollen extracts without dilutional effect

Autor: María Angeles Lara, Gemma Vanesa Sánchez, L. Begona, Juan A. Asturias, Alberto Martínez, Joaquín Quiralte, Carmen Arilla, Javier Monteserín, Begoña Madariaga, María Cruz Gómez-Fernández, Luis Andrés López Fernández

Publikováno v: Immunotherapy. 11:1031-1042

Aim: To evaluate tolerability of subcutaneous immunotherapy, in a polymerized mixture ( Olea europaea/ Phleum pratense) depot presentation. Patients & methods: A total of 47 poly-allergic patients received: an abbreviated schedule with three injectio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34f2e9ba2165653425fb16f4bd36d814
https://doi.org/10.2217/imt-2019-0051

Rational Design, Structure–Activity Relationship, and Immunogenicity of Hypoallergenic Pru p 3 Variants

Autor: Montserrat Fernandez-Rivas, Bettina M. Jensen, Josef Laimer, Gabriele Gadermaier, Isabel Pablos, Antonio Portolés, Fatima Ferreira, Laurian Jongejan, Juan A. Asturias, Serge A. Versteeg, Lars K. Poulsen, Nikolaos G. Papadopoulos, Peter Briza, Adriano Mari, Markus Steiner, Neil M. Rigby, Angelika Hörschläger, Peter Lackner, Stephanie Pauline Eichhorn, Ronald van Ree

Publikováno v: Molecular Nutrition & Food Research
Eichhorn, S, Hörschläger, A, Steiner, M, Laimer, J, Jensen, B M, Versteeg, S A, Pablos, I, Briza, P, Jongejan, L, Rigby, N, Asturias, J A, Portolés, A, Fernandez-Rivas, M, Papadopoulos, N G, Mari, A, Poulsen, L K, Lackner, P, van Ree, R, Ferreira, F & Gadermaier, G 2019, ' Rational Design, Structure-Activity Relationship, and Immunogenicity of Hypoallergenic Pru p 3 Variants ', Molecular Nutrition & Food Research, vol. 63, no. 18, e1900336 . https://doi.org/10.1002/mnfr.201900336
Eichhorn, S, Hörschläger, A, Steiner, M, Laimer, J, Jensen, B M, Versteeg, S A, Pablos, I, Briza, P, Jongejan, L, Rigby, N, Asturias, J A, Portolés, A, Fernandez-Rivas, M, Papadopoulos, N G, Mari, A, Poulsen, L K, Lackner, P, van Ree, R, Ferreira, F & Gadermaier, G 2019, ' Rational Design, Structure–Activity Relationship, and Immunogenicity of Hypoallergenic Pru p 3 Variants ', Molecular Nutrition and Food Research . https://doi.org/10.1002/mnfr.201900336
Molecular nutrition & food research. Wiley-VCH Verlag

Scope Allergies to lipid transfer proteins involve severe adverse reactions; thus, effective and sustainable therapies are desired. Previous attempts disrupting disulfide bonds failed to maintain immunogenicity; thus, the aim is to design novel hypoa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91b9a9ac0b1ad05f26ead459a26cbba7
http://europepmc.org/articles/PMC6790652

Standardization of allergen products: 3. Validation of candidate European Pharmacopoeia standard methods for quantification of major birch allergen Bet v 1

Autor: A Costanzo, J. Dayan-Kenigsberg, Domingo Barber, S. Döring, Stefan Vieths, F. Führer, Julia Zimmer, Martin D. Chapman, Oliver Dehus, A. Daas, E. Sandberg, Carlo Pini, A. Ledesma, Thomas Holzhauser, Philippe Moingeon, R. van Ree, Greg Plunkett, Juan A. Asturias, Ingrid Sander, K.H Buchheit, K. M. Hanschmann, D. Strecker, S. Kaul, Gerald Reese, Jerónimo Carnés, Emmanuel Nony, C. Valerio

Publikováno v: Allergy, 71(10), 1414-1424. Wiley-Blackwell

Background The BSP090 project aims at establishing European Pharmacopoeia Reference Substances in combination with the corresponding ELISA methods for the quantification of major allergens in allergen products. Two sandwich ELISAs proved suitable for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f48eefb9f43db34527e5b87370ced19
https://doi.org/10.1111/all.12898

Phase I study of subcutaneous allergen immunotherapy with Dermatophagoides pteronyssinus in patients with allergic rhinoconjunctivitis with or without asthma

Autor: Ignacio Antépara Ercoreca, Begoña Madariaga Goirigolzarri, Ana Ponte Tellechea, Ignacio Jáuregui Presa, Dolores Hernández Fernández de Rojas, Ethel Ibáñez Echevarría, Pedro M. Gamboa Setién, Juan A. Asturias, Araitz Landeta Manzano

Publikováno v: IMMUNOTHERAPY
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
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Aim: A double-blind placebo-controlled study was conducted according to EMA guidelines, to evaluate safety, tolerability and short-term treatment effects of three updosing regimens of Dermatophagoides pteronyssinus subcutaneous allergen immunotherapy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32c00133c9eb2f68bf48e4a163b826b1
https://doi.org/10.2217/imt.15.13