Zobrazeno 1 - 10
of 146
pro vyhledávání: '"Juan, Valcárcel"'
Intron detention tightly regulates the stemness/differentiation switch in the adult neurogenic niche
Autor:
Ainara González-Iglesias, Aida Arcas, Ana Domingo-Muelas, Estefania Mancini, Joan Galcerán, Juan Valcárcel, Isabel Fariñas, M. Angela Nieto
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract The adult mammalian brain retains some capacity to replenish neurons and glia, holding promise for brain regeneration. Thus, understanding the mechanisms controlling adult neural stem cell (NSC) differentiation is crucial. Paradoxically, adu
Externí odkaz:
https://doaj.org/article/4116623c87df4b3fb1ecede9d29f1a58
Autor:
Komal Soni, Pravin Kumar Ankush Jagtap, Santiago Martínez-Lumbreras, Sophie Bonnal, Arie Geerlof, Ralf Stehle, Bernd Simon, Juan Valcárcel, Michael Sattler
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract The RNA-binding motif protein RBM5 belongs to a family of multi-domain RNA binding proteins that regulate alternative splicing of genes important for apoptosis and cell proliferation and have been implicated in cancer. RBM5 harbors structura
Externí odkaz:
https://doaj.org/article/f91497348f68452ea6ee9cd287e24528
Autor:
Ainara González-Iglesias, Aida Arcas, Ana Domingo-Muelas, Estefania Mancini, Joan Galcerán, Juan Valcárcel, Isabel Fariñas, M. Angela Nieto
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/5687f0b58b1a4ebfbe36976c0ac84aef
Autor:
Claudia Vivori, Panagiotis Papasaikas, Ralph Stadhouders, Bruno Di Stefano, Anna Ribó Rubio, Clara Berenguer Balaguer, Serena Generoso, Anna Mallol, José Luis Sardina, Bernhard Payer, Thomas Graf, Juan Valcárcel
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-30 (2021)
Abstract Background Somatic cell reprogramming is the process that allows differentiated cells to revert to a pluripotent state. In contrast to the extensively studied rewiring of epigenetic and transcriptional programs required for reprogramming, th
Externí odkaz:
https://doaj.org/article/928f71eebddd447f9050eb912dcd5992
Autor:
Sandra Keiper, Panagiotis Papasaikas, Cindy L. Will, Juan Valcárcel, Cyrille Girard, Reinhard Lührmann
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Human spliceosome components Smu1 and RED regulate alternative splicing. Here the authors show that Smu1 and RED are also required for constitutive splicing of short introns.
Externí odkaz:
https://doaj.org/article/4553e27de950463e8f18f5857d925e60
Autor:
Jonàs Juan-Mateu, Simon Bajew, Marta Miret-Cuesta, Luis P. Íñiguez, Amaya Lopez-Pascual, Sophie Bonnal, Goutham Atla, Sílvia Bonàs-Guarch, Jorge Ferrer, Juan Valcárcel, Manuel Irimia
Publikováno v:
Nature Metabolism. 5:219-236
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bfd518d9cccd84d23266fee0acff0956
https://doi.org/10.1038/s42255-022-00734-2
https://doi.org/10.1038/s42255-022-00734-2
Publikováno v:
Nature Reviews Genetics. 24:251-269
The removal of introns from mRNA precursors and its regulation by alternative splicing are key for eukaryotic gene expression and cellular function, as evidenced by the numerous pathologies induced or modified by splicing alterations. Major recent ad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::428e5627af2412292d2d71e1e154f256
https://doi.org/10.1038/s41576-022-00556-8
https://doi.org/10.1038/s41576-022-00556-8
Publikováno v:
eLife, Vol 9 (2020)
Genetic analyses and systematic mutagenesis have revealed that synonymous, non-synonymous and intronic mutations frequently alter the inclusion levels of alternatively spliced exons, consistent with the concept that altered splicing might be a common
Externí odkaz:
https://doaj.org/article/2e3242a6beb2476fa8d5a3419ec4f6a9
Autor:
Keiko Horiuchi, Serafín Perez-Cerezales, Panagiotis Papasaikas, Priscila Ramos-Ibeas, Angela Patricia López-Cardona, Ricardo Laguna-Barraza, Noelia Fonseca Balvís, Eva Pericuesta, Raul Fernández-González, Benjamín Planells, Alberto Viera, Jose Angel Suja, Pablo Juan Ross, Francisco Alén, Laura Orio, Fernando Rodriguez de Fonseca, Belén Pintado, Juan Valcárcel, Alfonso Gutiérrez-Adán
Publikováno v:
Cell Reports, Vol 23, Iss 1, Pp 143-155 (2018)
Summary: The U2AF35-like ZRSR1 has been implicated in the recognition of 3′ splice site during spliceosome assembly, but ZRSR1 knockout mice do not show abnormal phenotypes. To analyze ZRSR1 function and its precise role in RNA splicing, we generat
Externí odkaz:
https://doaj.org/article/d212e33fab784884b791d952a00bf831
Autor:
Metehan Cifdaloz, Lisa Osterloh, Osvaldo Graña, Erica Riveiro-Falkenbach, Pilar Ximénez-Embún, Javier Muñoz, Cristina Tejedo, Tonantzin G. Calvo, Panagiotis Karras, David Olmeda, Belén Miñana, Gonzalo Gómez-López, Estela Cañon, Eduardo Eyras, Haihong Guo, Ferdinand Kappes, Pablo L. Ortiz-Romero, Jose L. Rodríguez-Peralto, Diego Megías, Juan Valcárcel, María S. Soengas
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-18 (2017)
Hundreds of mRNA binding proteins (mRBPs) have been described in mammalian cells. Here, the authors identify RBPs differentially regulated in melanoma, and show the RBP CELF1 controlling a distinct set of protumorigenic factors.
Externí odkaz:
https://doaj.org/article/1340379aab9748ac8e9ce5a84d0a223c