Zobrazeno 1 - 10 of 31 pro vyhledávání: '"Juan, Perucho"'
1
Akademický článek
Trehalose ameliorates dopaminergic and tau pathology in parkin deleted/tau overexpressing mice through autophagy activation
Autor: Jose A. Rodríguez-Navarro, Laura Rodríguez, María J. Casarejos, Rosa M. Solano, Ana Gómez, Juan Perucho, Ana María Cuervo, Justo García de Yébenes, María A. Mena
Publikováno v: Neurobiology of Disease, Vol 39, Iss 3, Pp 423-438 (2010)
Tauopathies are neurodegenerative diseases, sporadic or familial, mainly characterized by dementia and parkinsonism associated to atrophy of the frontotemporal cortex and the basal ganglia, with deposition of abnormal tau in brain. Hereditary tauopat
Externí odkaz: https://doaj.org/article/cbb3c170724f48328ba09b9e783b62b5
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2
Akademický článek
Trehalose improves human fibroblast deficits in a new CHIP-mutation related ataxia.
Autor: Maria Jose Casarejos, Juan Perucho, Jose Luis López-Sendón, Justo García de Yébenes, Conceição Bettencourt, Ana Gómez, Carolina Ruiz, Peter Heutink, Patrizia Rizzu, Maria Angeles Mena
Publikováno v: PLoS ONE, Vol 9, Iss 9, p e106931 (2014)
In this work we investigate the role of CHIP in a new CHIP-mutation related ataxia and the therapeutic potential of trehalose. The patient's fibroblasts with a new form of hereditary ataxia, related to STUB1 gene (CHIP) mutations, and three age and s
Externí odkaz: https://doaj.org/article/de9a4aeee95b4cd98e86dbf0be1d5aba
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3
Akademický článek
Trehalose reverses cell malfunction in fibroblasts from normal and Huntington's disease patients caused by proteosome inhibition.
Autor: Maria Angeles Fernandez-Estevez, Maria Jose Casarejos, Jose López Sendon, Juan Garcia Caldentey, Carolina Ruiz, Ana Gomez, Juan Perucho, Justo García de Yebenes, Maria Angeles Mena
Publikováno v: PLoS ONE, Vol 9, Iss 2, p e90202 (2014)
Huntington's disease (HD) is a neurodegenerative disorder characterized by progressive motor, cognitive and psychiatric deficits, associated with predominant loss of striatal neurons and is caused by polyglutamine expansion in the huntingtin protein.
Externí odkaz: https://doaj.org/article/50754b262a4046d690e3cf0cd20f5dae
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4
Akademický článek
Striatal infusion of glial conditioned medium diminishes huntingtin pathology in r6/1 mice.
Autor: Juan Perucho, Maria José Casarejos, Ana Gómez, Carolina Ruíz, Maria Ángeles Fernández-Estevez, Maria Paz Muñoz, Justo García de Yébenes, Maria Ángeles Mena
Publikováno v: PLoS ONE, Vol 8, Iss 9, p e73120 (2013)
Huntington's disease is a neurodegenerative disorder caused by an expansion of CAG repeats in the huntingtin gene which produces widespread neuronal and glial pathology. We here investigated the possible therapeutic role of glia or glial products in
Externí odkaz: https://doaj.org/article/a0de222dbf854f88a8490550507343c2
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5
Liver Growth Factor 'LGF' as a Therapeutic Agent for Alzheimer’s Disease
Autor: Diana Reimers, María José Casarejos, Juan Perucho, Adriano Jimenez-Escrig, Gonzalo M. Ulzurrun de Asanza, Eulalia Bazán, Manuela Vallejo-Muñoz, Rafael Gonzalo-Gobernado, Ana M. Gómez
Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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International Journal of Molecular Sciences, Vol 21, Iss 9201, p 9201 (2020)
International Journal of Molecular Sciences
Volume 21
Issue 23
Alzheimer&rsquo
s disease (AD) is a progressive degenerative disorder and the most common cause of dementia in aging populations. Although the pathological hallmarks of AD are well defined, currently no effective therapy exists. Liver growth fac
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58beaeb24eca892ca31c19e88caa3c80
http://hdl.handle.net/10261/225672
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6
Singular Location and Signaling Profile of Adenosine A
Autor: Estefanía, Moreno, Anna, Chiarlone, Mireia, Medrano, Mar, Puigdellívol, Lucka, Bibic, Lesley A, Howell, Eva, Resel, Nagore, Puente, María J, Casarejos, Juan, Perucho, Joaquín, Botta, Nuria, Suelves, Francisco, Ciruela, Silvia, Ginés, Ismael, Galve-Roperh, Vicent, Casadó, Pedro, Grandes, Beat, Lutz, Krisztina, Monory, Enric I, Canela, Carmen, Lluís, Peter J, McCormick, Manuel, Guzmán
Publikováno v: Neuropsychopharmacology
The dorsal striatum is a key node for many neurobiological processes such as motor activity, cognitive functions, and affective processes. The proper functioning of striatal neurons relies critically on metabotropic receptors. Specifically, the main
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7119661042eddf3a9325f25bc5559f7f
https://pubmed.ncbi.nlm.nih.gov/28102227
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7
Parkin Null Cortical Neuronal/Glial Cultures are Resistant to Amyloid-β1-42 Toxicity: A Role for Autophagy?
Autor: Justo García de Yébenes, Ana M. Gómez, Juan Perucho, Maria Angeles Mena, Rosa M. Solano, María José Casarejos
Publikováno v: Journal of Alzheimer's Disease. 32:57-76
Dementia occurs often in late stages of Parkinson's disease (PD) but its cause is unknown. Likewise there is little information about the interaction between proteins that produce PD and those implicated in Alzheimer's disease (AD). Here we have inve
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26fd2f9128aa6eaafefb618d20d0b094
https://doi.org/10.3233/jad-2012-120406
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8
Trehalose Protects from Aggravation of Amyloid Pathology Induced by Isoflurane Anesthesia in APPswe Mutant Mice
Autor: Maria Angeles Mena, Rosa M. Solano, Justo García de Yébenes, María José Casarejos, Ana M. Gómez, Juan Perucho
Publikováno v: Current Alzheimer Research. 9:334-343
There is an open controversy about the role of surgery and anesthesia in the pathogenesis of Alzheimer's disease (AD). Clinical studies have shown a high prevalence of these procedures in subjects with AD but the interpretation of these studies is di
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8a4314bf826dcb8745c8dcf76af54c2
https://doi.org/10.2174/156720512800107573
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9
Anesthesia with Isoflurane Increases Amyloid Pathology in Mice Models of Alzheimer'S Disease
Autor: Isabel Rubio, María José Casarejos, Juan Perucho, Ana M. Gómez, Justo García de Yébenes, Jose A. Rodriguez-Navarro, Maria Angeles Mena, Rosa M. Solano
Publikováno v: Journal of Alzheimer's Disease. 19:1245-1257
There is a great interest in the environmental and genetic factors which modify the risk of Alzheimer's disease since the manipulation of these factors could help to change the prevalence and natural course of this disease. Among the first group, ane
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc26d4ed0d7ad597ae2f914369186d6e
https://doi.org/10.3233/jad-2010-1318
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10
The effects of parkin suppression on the behaviour, amyloid processing, and cell survival in APP mutant transgenic mice
Autor: Israel Ampuero, Maria Angeles Mena, Isabel Rubio, Jose A. Rodriguez-Navarro, Justo García de Yébenes, Rosa M. Solano, María José Casarejos, Izaskun Rodal, Juan Perucho, Eva Carro, Ana Gómez
Publikováno v: Experimental Neurology. 221:54-67
Parkin suppression induces accumulation of beta-amyloid in mutant tau mice. We studied the effect of parkin suppression on behaviour and brain pathology in APP(swe) mutant mice. We produced double mutant mice with human mutated APP(swe)+partial (hemi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ad86f1c93fd00134d10a694fa195c8c
https://doi.org/10.1016/j.expneurol.2009.09.029
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