Výsledky vyhledávání

EST64454: a Highly Soluble σ1 Receptor Antagonist Clinical Candidate for Pain Management

Autor: Antoni Torrens, José Miguel Vela, Adriana Lorente, Ana Montero, Sandra Yeste, Ana María Caamaño, Alba Vidal-Torres, J.L. Diaz, Juan Enjo, Miquel Martin, Carmen Almansa, Inés Álvarez, Cristina Sicre, Rafael Maldonado, Mónica García, Adriana Port, Cruz Miguel Cendán, Beatriz de la Puente

Publikováno v: Journal of Medicinal Chemistry. 63:14979-14988

The synthesis and pharmacological activity of a new series of pyrazoles that led to the identification of 1-(4-(2-((1-(3,4-difluorophenyl)-1H-pyrazol-3-yl)methoxy)ethyl)piperazin-1-yl)ethanone (9k, EST64454) as a σ1 receptor (σ1R) antagonist clinic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::748bb7ac3f47098d47adb62f112a37c0
https://doi.org/10.1021/acs.jmedchem.0c01575

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EST64454: a Highly Soluble σ

Autor: José Luis, Díaz, Mónica, García, Antoni, Torrens, Ana María, Caamaño, Juan, Enjo, Cristina, Sicre, Adriana, Lorente, Adriana, Port, Ana, Montero, Sandra, Yeste, Inés, Álvarez, Miquel, Martín, Rafael, Maldonado, Beatriz, de la Puente, Alba, Vidal-Torres, Cruz Miguel, Cendán, José Miguel, Vela, Carmen, Almansa

Publikováno v: Journal of medicinal chemistry. 63(23)

The synthesis and pharmacological activity of a new series of pyrazoles that led to the identification of 1-(4-(2-((1-(3,4-difluorophenyl)-1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a21267337558c9ea591c3d747056e49e
https://pubmed.ncbi.nlm.nih.gov/33237785

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New fluorescent probes for testing combinatorial catalysts with phosphodiesterase and esterase activities

Autor: Francisco Caturla, Juan Enjo, Stephanie Le Serre, M.Carmen Bernabeu

Publikováno v: Tetrahedron. 60:1903-1911

Combinatorial development of new catalysts with phosphodiesterase and esterase activities requires specific fluorescent probes for rapid visual detection of hydrolytic activity. Such fluorescent probes have been synthesized with special attention to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6212be76ef1b685ec34814a689660553
https://doi.org/10.1016/j.tet.2003.12.032

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ChemInform Abstract: Photochemistry of Tosylstilbenoids in the Preparation of Complex Heterocyclic Compounds. Synthesis of a Cyclopropafuroindolone Analogue of the DNA-Alkylating Section of the Antitumor Compound CC-1065

Autor: Juan Enjo, Luis Castedo, Gabriel Tojo

Publikováno v: ChemInform. 32

[reaction in text] A novel photocyclization of tosylstilbenoids is used in the preparation of a cyclopropafuroindolone analogue of the DNA-alkylating unit of the antitumor compound CC-1065.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::816d8de6affb9b4fecdd4da5cdba0715
https://doi.org/10.1002/chin.200136237

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Derivatives of Methyl 5-Methyl-4-oxo-1,2,4,5,8,8a- hexahydrocyclopropa[c]-pyrrolo[3,2-e]indole-7- carboxylate: A Case of Inverse Electronic Effects on the Reactivity of CC-1065 Derivatives

Autor: Ana Ríos, José Delamano, Jesús J. Fernández, Juan Enjo, Dolores Garcia Gravalos, Carmen López, Gabriel Tojo, Luis Castedo, Ramón Leis, Carlos F. Marcos

Publikováno v: Journal of the American Chemical Society. 123:5102-5103

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4e780736dc20996189a2e1801cf2e91
https://doi.org/10.1021/ja005704n

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Derivatives of Methyl 5-Methyl-4-oxo-1,2,4,5,8,8a-hexahydrocyclopropa[3]pyrrolo[3,2-e]indole-3-carboxylate: A Case of Inverse Electronic Effects on the Reactivity of CC-1065 Derivatives [J. Am. Chem. Soc. 2001, 123 (21), 5102−5103]

Autor: Ramón Leis, Dolores Garcia Gravalos, Carmen López, Juan Enjo, Gabriel Tojo, Jesús J. Fernández, José Delamano, Carlos F. Marcos, Ana Ríos, Luis Castedo

Publikováno v: Journal of the American Chemical Society. 124:9656-9656

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d634b2511aebea5cbdf490f69d56ce78
https://doi.org/10.1021/ja025108o

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Photochemistry of Tosylstilbenoids in the Preparation of Complex Heterocyclic Compounds. Synthesis of a Cyclopropafuroindolone Analogue of the DNA-Alkylating Section of the Antitumor Compound CC-1065

Autor: Juan Enjo, Gabriel Tojo, Luis Castedo

Publikováno v: Organic Letters. 3:3425-3425

[reaction in text] A novel photocyclization of tosylstilbenoids is used in the preparation of a cyclopropafuroindolone analogue of the DNA-alkylating unit of the antitumor compound CC-1065.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9373ce220609ec64e27b9691a66cc316
https://doi.org/10.1021/ol016555w

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