Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Ju-xian Song"'
Autor:
Wenjia Lin, Zhao Li, Guangfeng Liang, Runjin Zhou, Xiaoyan Zheng, Rongrong Tao, Qingwei Huo, Chengfu Su, Min Li, Nenggui Xu, Chunzhi Tang, Ju-Xian Song
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-16 (2023)
Abstract Background The impairment in the autophagy-lysosomal pathway (ALP) and the activation of NLR family pyrin domain containing 3 (NLRP3) inflammasome represent two molecular events leading to neurodegeneration and neuroinflammation in Alzheimer
Externí odkaz:
https://doaj.org/article/fafb282201584b0caa73453098e4686f
Autor:
Zi-Ying Wang, Jia Liu, Zhou Zhu, Cheng-Fu Su, Sravan Gopalkrishnashetty Sreenivasmurthy, Ashok Iyaswamy, Jia-Hong Lu, Gang Chen, Ju-Xian Song, Min Li
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 164, Iss , Pp 114979- (2023)
Externí odkaz:
https://doaj.org/article/90bfbf62e56b428a810bf080f6c6ad0a
Autor:
Sravan Gopalkrishnashetty Sreenivasmurthy, Ashok Iyaswamy, Senthilkumar Krishnamoorthi, Rambabu N. Reddi, Ananth Kumar Kammala, Karthick Vasudevan, Sanjib Senapati, Zhou Zhu, Cheng-Fu Su, Jia Liu, Xin-Jie Guan, Ka-Kit Chua, King-Ho Cheung, Hubiao Chen, Hong-Jie Zhang, Yuan Zhang, Ju-Xian Song, Siva Sundara Kumar Durairajan, Min Li
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Emerging evidence from Alzheimer’s disease (AD) patients suggests that reducing tau pathology can restore cognitive and memory loss. To reduce tau pathology, it is critical to find brain-permeable tau-degrading small molecules that are safe and eff
Externí odkaz:
https://doaj.org/article/ad4864ffb5f248789897756ed41a5785
Autor:
Ashok Iyaswamy, Xueli Wang, Senthilkumar Krishnamoorthi, Venkatapathy Kaliamoorthy, Sravan G. Sreenivasmurthy, Siva Sundara Kumar Durairajan, Ju-Xian Song, Benjamin Chun-kit Tong, Zhou Zhu, Cheng-Fu Su, Jia Liu, King-Ho Cheung, Jia-Hong Lu, Jie-Qiong Tan, Hung Wing Li, Man Shing Wong, Min Li
Publikováno v:
Redox Biology, Vol 51, Iss , Pp 102280- (2022)
Accumulation of amyloid-β (Aβ) oligomers and phosphorylated Tau aggregates are crucial pathological events or factors that cause progressive neuronal loss, and cognitive impairments in Alzheimer's disease (AD). Current medications for AD have faile
Externí odkaz:
https://doaj.org/article/17aea313beb2415fa02ef3251a86296c
Autor:
Zi-Ying Wang, Jia Liu, Zhou Zhu, Cheng-Fu Su, Sravan Gopalkrishnashetty Sreenivasmurthy, Ashok Iyaswamy, Jia-Hong Lu, Gang Chen, Ju-Xian Song, Min Li
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 133, Iss , Pp 110968- (2021)
Neurodegenerative diseases (NDs) are common chronic diseases related to progressive damage of the nervous system. Globally, the number of people with an ND is dramatically increasing consistent with the fast aging of society and one of the common fea
Externí odkaz:
https://doaj.org/article/fc86641ecc3a402b9deaafff93260d34
Autor:
Chuanbin Yang, Zhou Zhu, Benjamin Chun-Kit Tong, Ashok Iyaswamy, Wen-Jian Xie, Yu Zhu, Sravan Gopalkrishnashetty Sreenivasmurthy, Krishnamoorthi Senthilkumar, King-Ho Cheung, Ju-Xian Song, Hong-Jie Zhang, Min Li
Publikováno v:
Redox Biology, Vol 32, Iss , Pp - (2020)
TFEB (transcription factor EB) and TFE3 (transcription factor E3) are “master regulators” of autophagy and lysosomal biogenesis. The stress response p38 mitogen-activated protein (MAP) kinases affect multiple intracellular responses including inf
Externí odkaz:
https://doaj.org/article/c04ef8a7b81a484cbf678263a4064a0f
Autor:
Sandeep Malampati, Ju-Xian Song, Benjamin Chun-Kit Tong, Anusha Nalluri, Chuan-Bin Yang, Ziying Wang, Sravan Gopalkrishnashetty Sreenivasmurthy, Zhou Zhu, Jia Liu, Chengfu Su, Senthilkumar Krishnamoorthi, Ashok Iyaswamy, King-Ho Cheung, Jia-Hong Lu, Min Li
Publikováno v:
Cells, Vol 9, Iss 2, p 311 (2020)
Alzheimer’s disease (AD) is one of the most common neurodegenerative diseases in older individuals with specific neuropsychiatric symptoms. It is a proteinopathy, pathologically characterized by the presence of misfolded protein (Aβ and Tau) aggre
Externí odkaz:
https://doaj.org/article/a6213bac3db64f818ce230ea46972b64
Autor:
Ka-Kit Chua, Adrian Wong, Kam-Wa Chan, Yin-Kei Lau, Zhao-Xiang Bian, Jia-Hong Lu, Liang-Feng Liu, Lei-Lei Chen, Ka-Ho Chan, Kim-Pong Tse, Anne Chan, Ju-Xian Song, Justin Wu, Li-Xing Zhu, Vincent Mok, Min Li
Publikováno v:
Parkinson's Disease, Vol 2017 (2017)
Nonmotor symptoms (NMS) of Parkinson’s disease (PD) have devastating impacts on both patients and their caregivers. Jiawei-Liujunzi Tang (JLT) has been used to treat some NMS of PD based on the Chinese medicine theory since Qing dynasty. Here we re
Externí odkaz:
https://doaj.org/article/d993dd3d137f41d9b137f61683f1a6cf
Autor:
Siva Sundara Kumar Durairajan, Ying-Yu Huang, Pui-Yee Yuen, Lei-Lei Chen, Ka-Yan Kwok, Liang-Feng Liu, Ju-Xian Song, Quan-Bin Han, Lei Xue, Sookja K Chung, Jian-Dong Huang, Larry Baum, Sanjib Senapati, Min Li
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e92954 (2014)
Huanglian-Jie-Du-Tang (HLJDT) is a famous traditional Chinese herbal formula that has been widely used clinically to treat cerebral ischemia. Recently, we found that berberine, a major alkaloid compound in HLJDT, reduced amyloid-β (Aβ) accumulation
Externí odkaz:
https://doaj.org/article/9e0f436b4fef4bf09bf775b4915f6366
Autor:
Zhou Zhu, Liang-feng Liu, Cheng-fu Su, Jia Liu, Benjamin Chun-Kit Tong, Ashok Iyaswamy, Senthilkumar Krishnamoorthi, Sravan Gopalkrishnashetty Sreenivasmurthy, Xin-jie Guan, Yu-xuan Kan, Wen-jian Xie, Chen-liang Zhao, King-ho Cheung, Jia-hong Lu, Jie-qiong Tan, Hong-jie Zhang, Ju-xian Song, Min Li
Publikováno v:
Acta Pharmacologica Sinica. 43:2511-2526
Increasing evidence shows that autophagy impairment is involved in the pathogenesis and progression of neurodegenerative diseases including Parkinson's disease (PD). We previously identified a natural alkaloid named corynoxine B (Cory B) as a neurona