Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Ju-hui Zhang"'
Publikováno v:
Molecules, Vol 25, Iss 4, p 975 (2020)
The construction of efficient and low toxic non-viral gene delivery vectors is of great significance for gene therapy. Herein, two novel polycations were constructed via Michael addition from low molecular weight polyethylenimine (PEI) 600 Da and ami
Externí odkaz:
https://doaj.org/article/77d674aa2d3242eb91f61581aeb3e8d3
Publikováno v:
ACS Applied Bio Materials. 3:3526-3534
With the rise and development of gene therapy, it is of great significance to develop highly efficient and biocompatible polymeric gene carriers. In this work, a series of heteropolymers from ring-opening polymerization of diepoxide compounds and var
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d8daaba24a4f3cc60f1e22409fc82f3
https://doi.org/10.1021/acsabm.0c00118
https://doi.org/10.1021/acsabm.0c00118
Autor:
Ya-Ping Xiao, Xi He, Qing-Ying Yu, Xiao-Qi Yu, Ji Zhang, Yu-Rong Zhan, Ju-Hui Zhang, Yan-Hong Liu
Publikováno v:
New Journal of Chemistry. 43:12109-12117
The efficient delivery of therapeutic genes remains a major challenge in realizing a feasible gene-based treatment. Herein, a versatile oligopeptide, glutathione, was introduced to construct novel non-viral cationic gene vectors. Reduced/oxidized for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2bf185c9d6b0bc760c07149fd831f78b
https://doi.org/10.1039/c9nj02396h
https://doi.org/10.1039/c9nj02396h
Publikováno v:
Molecules
Volume 25
Issue 4
Molecules, Vol 25, Iss 4, p 975 (2020)
Volume 25
Issue 4
Molecules, Vol 25, Iss 4, p 975 (2020)
The construction of efficient and low toxic non-viral gene delivery vectors is of great significance for gene therapy. Herein, two novel polycations were constructed via Michael addition from low molecular weight polyethylenimine (PEI) 600 Da and ami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2895ddaf58b614143e89d7c828612c0
https://pubmed.ncbi.nlm.nih.gov/32098282
https://pubmed.ncbi.nlm.nih.gov/32098282
Autor:
Ya-Ping Xiao, Xiao-Qi Yu, Qing-Ying Yu, Chao-Ran Luan, Ju-Hui Zhang, Xiaochuan Chen, Xi Wei, Yan-Hong Liu, Ji Zhang
Publikováno v:
Polymer. 134:53-62
Gene therapy has shown great potential in the treatment of various diseases, and the development of low-toxic and efficient gene carriers is still one of the burning issues for gene therapy. PEGylation is generally regarded as an efficient strategy t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00fdad1f46f4cd3aae0db70541c2725e
https://doi.org/10.1016/j.polymer.2017.11.059
https://doi.org/10.1016/j.polymer.2017.11.059
Autor:
Xi Wei, Xiaochuan Chen, Bing Wang, Zheng Huang, Xiao-Qi Yu, Ping Chen, Ji Zhang, Yan-Hong Liu, Wei Zhang, Qing-Ying Yu, Ju-Hui Zhang
Publikováno v:
Polymer Chemistry. 8:7486-7498
With the aim to develop a novel multifunctional gene delivery system that may overcome the common barriers of gene transfection, two amphiphilic molecules with tetraphenyl ethylene (TPE) as a hydrophobic moiety and linear PEI-galactose as a hydrophil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4da582a70d418f1c86fc26c353280db5
https://doi.org/10.1039/c7py01520h
https://doi.org/10.1039/c7py01520h
Publikováno v:
European journal of medicinal chemistry. 182
Polycation carriers hold great potential in gene therapy. However, they usually suffer from obvious cytotoxicity and unsatisfactory transfection efficiency. In this report, a series of fluorobenzene substituted and thioacetal contained polycations (T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7e4f213109675ab42d336f00408b21e
https://pubmed.ncbi.nlm.nih.gov/31494476
https://pubmed.ncbi.nlm.nih.gov/31494476
Autor:
Shuo Li, Ju-Hui Zhang, Miao-Miao Xun, Xiao-Qi Yu, Ji Zhang, Ya-Ping Xiao, Yan-Hong Liu, Qian Guo
Publikováno v:
RSC Advances. 6:5391-5400
A significant gap currently exists in our understanding of how the detailed chemical characteristics of polycationic gene carriers can improve their delivery performance. The aim of this contribution is to develop a branched polyethylenimine (PEI)-mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3327d05c8f9922407318058c6ce5a494
https://doi.org/10.1039/c5ra23715g
https://doi.org/10.1039/c5ra23715g
Publikováno v:
Polymers
Volume 10
Issue 10
Polymers, Vol 10, Iss 10, p 1080 (2018)
Volume 10
Issue 10
Polymers, Vol 10, Iss 10, p 1080 (2018)
The linking and modification of low molecular weight cationic polymers (oligomers) has become an attracted strategy to construct non-viral gene carriers with good transfection efficiency and much reduced cytotoxicity. In this study, PEI 600 Da was li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::298ec1afe16583f5bd2927e5957a29e5
Publikováno v:
Polymers
Volume 10
Issue 10
Polymers, Vol 10, Iss 10, p 1060 (2018)
Volume 10
Issue 10
Polymers, Vol 10, Iss 10, p 1060 (2018)
Rapid enzymatic degradation and fragmentation during DNA administration can result in limited gene expression, and consequently, poor efficacy. It is necessary to use novel vectors for DNA delivery. Herein, we aimed to design useful carriers for enha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33be9f0beeabc963e2cd0b7820f7812c