Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Ju Xian Song"'
Autor:
Wenjia Lin, Zhao Li, Guangfeng Liang, Runjin Zhou, Xiaoyan Zheng, Rongrong Tao, Qingwei Huo, Chengfu Su, Min Li, Nenggui Xu, Chunzhi Tang, Ju-Xian Song
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-16 (2023)
Abstract Background The impairment in the autophagy-lysosomal pathway (ALP) and the activation of NLR family pyrin domain containing 3 (NLRP3) inflammasome represent two molecular events leading to neurodegeneration and neuroinflammation in Alzheimer
Externí odkaz:
https://doaj.org/article/fafb282201584b0caa73453098e4686f
Autor:
Zi-Ying Wang, Jia Liu, Zhou Zhu, Cheng-Fu Su, Sravan Gopalkrishnashetty Sreenivasmurthy, Ashok Iyaswamy, Jia-Hong Lu, Gang Chen, Ju-Xian Song, Min Li
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 164, Iss , Pp 114979- (2023)
Externí odkaz:
https://doaj.org/article/90bfbf62e56b428a810bf080f6c6ad0a
Autor:
Sravan Gopalkrishnashetty Sreenivasmurthy, Ashok Iyaswamy, Senthilkumar Krishnamoorthi, Rambabu N. Reddi, Ananth Kumar Kammala, Karthick Vasudevan, Sanjib Senapati, Zhou Zhu, Cheng-Fu Su, Jia Liu, Xin-Jie Guan, Ka-Kit Chua, King-Ho Cheung, Hubiao Chen, Hong-Jie Zhang, Yuan Zhang, Ju-Xian Song, Siva Sundara Kumar Durairajan, Min Li
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Emerging evidence from Alzheimer’s disease (AD) patients suggests that reducing tau pathology can restore cognitive and memory loss. To reduce tau pathology, it is critical to find brain-permeable tau-degrading small molecules that are safe and eff
Externí odkaz:
https://doaj.org/article/ad4864ffb5f248789897756ed41a5785
Autor:
Ashok Iyaswamy, Xueli Wang, Senthilkumar Krishnamoorthi, Venkatapathy Kaliamoorthy, Sravan G. Sreenivasmurthy, Siva Sundara Kumar Durairajan, Ju-Xian Song, Benjamin Chun-kit Tong, Zhou Zhu, Cheng-Fu Su, Jia Liu, King-Ho Cheung, Jia-Hong Lu, Jie-Qiong Tan, Hung Wing Li, Man Shing Wong, Min Li
Publikováno v:
Redox Biology, Vol 51, Iss , Pp 102280- (2022)
Accumulation of amyloid-β (Aβ) oligomers and phosphorylated Tau aggregates are crucial pathological events or factors that cause progressive neuronal loss, and cognitive impairments in Alzheimer's disease (AD). Current medications for AD have faile
Externí odkaz:
https://doaj.org/article/17aea313beb2415fa02ef3251a86296c
Autor:
Zi-Ying Wang, Jia Liu, Zhou Zhu, Cheng-Fu Su, Sravan Gopalkrishnashetty Sreenivasmurthy, Ashok Iyaswamy, Jia-Hong Lu, Gang Chen, Ju-Xian Song, Min Li
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 133, Iss , Pp 110968- (2021)
Neurodegenerative diseases (NDs) are common chronic diseases related to progressive damage of the nervous system. Globally, the number of people with an ND is dramatically increasing consistent with the fast aging of society and one of the common fea
Externí odkaz:
https://doaj.org/article/fc86641ecc3a402b9deaafff93260d34
Autor:
Chuanbin Yang, Zhou Zhu, Benjamin Chun-Kit Tong, Ashok Iyaswamy, Wen-Jian Xie, Yu Zhu, Sravan Gopalkrishnashetty Sreenivasmurthy, Krishnamoorthi Senthilkumar, King-Ho Cheung, Ju-Xian Song, Hong-Jie Zhang, Min Li
Publikováno v:
Redox Biology, Vol 32, Iss , Pp - (2020)
TFEB (transcription factor EB) and TFE3 (transcription factor E3) are “master regulators” of autophagy and lysosomal biogenesis. The stress response p38 mitogen-activated protein (MAP) kinases affect multiple intracellular responses including inf
Externí odkaz:
https://doaj.org/article/c04ef8a7b81a484cbf678263a4064a0f
Autor:
Zhou Zhu, Liang-feng Liu, Cheng-fu Su, Jia Liu, Benjamin Chun-Kit Tong, Ashok Iyaswamy, Senthilkumar Krishnamoorthi, Sravan Gopalkrishnashetty Sreenivasmurthy, Xin-jie Guan, Yu-xuan Kan, Wen-jian Xie, Chen-liang Zhao, King-ho Cheung, Jia-hong Lu, Jie-qiong Tan, Hong-jie Zhang, Ju-xian Song, Min Li
Publikováno v:
Acta Pharmacologica Sinica. 43:2511-2526
Increasing evidence shows that autophagy impairment is involved in the pathogenesis and progression of neurodegenerative diseases including Parkinson's disease (PD). We previously identified a natural alkaloid named corynoxine B (Cory B) as a neurona
Autor:
Sandeep Malampati, Ju-Xian Song, Benjamin Chun-Kit Tong, Anusha Nalluri, Chuan-Bin Yang, Ziying Wang, Sravan Gopalkrishnashetty Sreenivasmurthy, Zhou Zhu, Jia Liu, Chengfu Su, Senthilkumar Krishnamoorthi, Ashok Iyaswamy, King-Ho Cheung, Jia-Hong Lu, Min Li
Publikováno v:
Cells, Vol 9, Iss 2, p 311 (2020)
Alzheimer’s disease (AD) is one of the most common neurodegenerative diseases in older individuals with specific neuropsychiatric symptoms. It is a proteinopathy, pathologically characterized by the presence of misfolded protein (Aβ and Tau) aggre
Externí odkaz:
https://doaj.org/article/a6213bac3db64f818ce230ea46972b64
Publikováno v:
Cancer Medicine
Cancer Medicine, Vol 10, Iss 20, Pp 7242-7252 (2021)
Cancer Medicine, Vol 10, Iss 20, Pp 7242-7252 (2021)
FNDC4 is highly homologous to the exercise‐associated myokine FNDC5/irisin, which is highly expressed and promotes the invasion and metastasis of HCC cells. However, the function of FNDC4 remains unknown. Here, we report that FNDC4, an extracellula
Autor:
Zhou Zhu, Chuanbin Yang, Zi-Ying Wang, Jieqiong Tan, Benjamin Chun-Kit Tong, Ashok Iyaswamy, Min Li, Jia-Hong Lu, Cheng-Fu Su, Ju-Xian Song, Senthilkumar Krishnamoorthi, Jia Liu, Shi-Ying Huang, King-Ho Cheung, Sravan Gopalkrishnashetty Sreenivasmurthy, Jia-Xi Wu
Publikováno v:
Acta Pharmacol Sin
Transcriptional factor EB (TFEB), a master regulator of autophagy and lysosomal biogenesis, is generally regarded as a pro-survival factor. Here, we identify that besides its effect on autophagy induction, TFEB exerts a pro-apoptotic effect in respon