Zobrazeno 1 - 10
of 174
pro vyhledávání: '"Ju Chien Cheng"'
Autor:
Li-Te Tai, Cheng-Yun Yeh, Yu-Jen Chang, Ju-Fang Liu, Kai-Cheng Hsu, Ju-Chien Cheng, Chih-Hao Lu
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 11, p 6105 (2024)
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is responsible for the current coronavirus disease pandemic. With the rapid evolution of variant strains, finding effective spike protein inhibitors is a logical and critical priority. Angi
Externí odkaz:
https://doaj.org/article/803ffb7c4cc84cd99653d5cd84cbb2e6
Autor:
Yung-Ju Yeh, Tai-Ling Chao, Yu-Jen Chang, Sui-Yuan Chang, Chih-Hao Lu, Chih-Hua Chao, Wen-Chi Su, Ching-Ping Tseng, Michael M.C. Lai, Ju-Chien Cheng
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 23, p 17040 (2023)
The continuous emergence of SARS-CoV-2 variants has led to a protracted global COVID-19 pandemic with significant impacts on public health and global economy. While there are currently available SARS-CoV-2 vaccines and therapeutics, most of the FDA-a
Externí odkaz:
https://doaj.org/article/8bc6bddbd23045f4a4432f61b692aeec
In vitro characterization of a small molecule PD-1 inhibitor that targets the PD-l/PD-L1 interaction
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Targeting the programmed cell death protein 1/programmed cell death ligand 1 (PD-1/PD-L1) axis with monoclonal antibodies (mAbs) represents a crucial breakthrough in anticancer therapy, but mAbs are limited by their poor oral bioavailability
Externí odkaz:
https://doaj.org/article/7877ddfc07c5458ea9a7787b84758998
Autor:
Yu-Jen Chang, Cheng-Yun Yeh, Ju-Chien Cheng, Yu-Qi Huang, Kai-Cheng Hsu, Yu-Feng Lin, Chih-Hao Lu
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Eradicating influenza A virus (IAV) is difficult, due to its genetic drift and reassortment ability. As the infectious cycle is initiated by the influenza glycoprotein, hemagglutinin (HA), which mediates the binding of virions to terminal si
Externí odkaz:
https://doaj.org/article/612921c1abcf4e3aab9f477b264a5b4c
Autor:
Hui-Ju Tsai, Ju-Chien Cheng, Man-Leng Kao, Hung-Pin Chiu, Yi-Hsuan Chiang, Ding-Ping Chen, Kun-Ming Rau, Hsiang-Ruei Liao, Ching-Ping Tseng
Publikováno v:
Cell & Bioscience, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract Background Bidirectional integrin αIIbβ3 signaling is essential for platelet activation. The platelet adaptor protein Disabled-2 (Dab2) is a key regulator of integrin signaling and is phosphorylated at serine 24 in eukaryotic cells. Howeve
Externí odkaz:
https://doaj.org/article/5a1e6dd35ef346cba8f30b10bf7c7740
Autor:
Kazuki Iwahana, Tatsuya Takemura, Ju Chien Cheng, Nami Ashizawa, Naoki Umeda, Kodai Sato, Ryota Kawakami, Rei Shimizu, Yuichiro Chinen, Naoto Yanai
Publikováno v:
IEEE Access, Vol 9, Pp 78293-78314 (2021)
Fast and accurate malicious domain detection is an essential research theme to prevent cybercrime, and machine learning is an attractive approach for detecting unseen malicious domains in the past decade. In this paper, we present MADMAX (MAchine lea
Externí odkaz:
https://doaj.org/article/7687dcec26e7486692e49b3cc31523c0
Autor:
Hsing-Ying Lee, Ni-Yen Yu, Shiang-Hsuan Lee, Hui-Ju Tsai, Chih-Ching Wu, Ju-Chien Cheng, Ding-Ping Chen, Ying-Ru Wang, Ching-Ping Tseng
Publikováno v:
Biomedical Journal, Vol 43, Iss 2, Pp 146-162 (2020)
Background: Podoplanin (PDPN) is a transmembrane glycoprotein that mediates tumor cell-induced platelets aggregation in different cancer types. Emerging data indicate that PDPN is a marker for poor prognosis of human oral squamous cell carcinoma (OSC
Externí odkaz:
https://doaj.org/article/7960ca20667f445882b99ab58675d70d
Autor:
Tse-Hung Huang, Pei-Wen Hsieh, Tsu-Jung Chen, Hui-Ju Tsai, Ju-Chien Cheng, Hsiang-Ruei Liao, Shun-Li Kuo, Ching-Ping Tseng
Publikováno v:
Pathogens, Vol 12, Iss 2, p 341 (2023)
Platelet hyper-reactivity and neutrophil extracellular trap (NET) formation contribute to the development of thromboembolic diseases for patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This study investigated the
Externí odkaz:
https://doaj.org/article/dda5a64cff7d42299d4951ac3b058e22
Autor:
Ju-Chien Cheng, Yi-Ju Chen, Chi-Wen Chuang, Ya-Hsuan Chao, Hui-Chi Huang, Chia-Chi Lin, Chih-Hua Chao
Publikováno v:
Molecules, Vol 27, Iss 23, p 8548 (2022)
Six new polyoxygenated terpenoids, podovirosanes A–F (1–6), and two known polyketides (7 and 8) were isolated from the roots of F. virosa. Their structures, along with absolute configurations, were deduced using spectroscopic analysis as well as
Externí odkaz:
https://doaj.org/article/7e1ca33d041e4431a49ba29c27b171ea
Publikováno v:
Royal Society Open Science, Vol 8, Iss 11 (2021)
Torque teno virus (TTV) is one of the most common human viruses and can infect an individual with multiple genotypes chronically and persistently. TTV group 6 is a recently discovered phylogenetic group first isolated from eastern Taiwan indigenes, b
Externí odkaz:
https://doaj.org/article/8f42d2bc08904fa7924e9ea6366b7d2b