Zobrazeno 1 - 10
of 237
pro vyhledávání: '"Jürgen Burhenne"'
Dose‐dependent induction of CYP3A activity by St. John's wort alone and in combination with rifampin
Autor:
Nicolas Hohmann, Anna S. Friedrichs, Jürgen Burhenne, Antje Blank, Gerd Mikus, Walter E. Haefeli
Publikováno v:
Clinical and Translational Science, Vol 17, Iss 8, Pp n/a-n/a (2024)
Abstract The dose dependence of the effect of enzyme inducers and the effect of the combined administration of two inducers that exert their effect via the same induction pathway (pregnane X receptor) have not been well studied. Using oral midazolam
Externí odkaz:
https://doaj.org/article/c52b7ca26c1344ab99e4623076718f5b
Autor:
Nicolas Hohmann, Martin Ronald Sprick, Moritz Pohl, Azaz Ahmed, Jürgen Burhenne, Marietta Kirchner, Lucian Le Cornet, Markus Kratzmann, Jacek Hajda, Albrecht Stenzinger, Karen Steindorf, Stefan Delorme, Heinz‐Peter Schlemmer, Sabine Riethdorf, Ron vanSchaik, Klaus Pantel, Jens Siveke, Thomas Seufferlein, Dirk Jäger, Walter E. Haefeli, Andreas Trumpp, Christoph Springfeld
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 12, Pp 2483-2493 (2023)
Abstract Expression of CYP3A5 protein is a basal and acquired resistance mechanism of pancreatic ductal adenocarcinoma cells conferring protection against the CYP3A and CYP2C8 substrate paclitaxel through metabolic degradation. Inhibition of CYP3A is
Externí odkaz:
https://doaj.org/article/c68c01273a54478990c71f106d610b42
Autor:
Gzona Bajraktari-Sylejmani, Cindy Bay, Lukas Gebauer, Jürgen Burhenne, Johanna Weiss, Max Sauter
Publikováno v:
Molecules, Vol 29, Iss 21, p 5162 (2024)
Metformin is the gold standard substrate for evaluating potential inhibitors of the organic cation transporters (OCTs). Here, we established a UPLC-MS/MS assay to quantify metformin in cell pellets with a range of 0.05–50 ng/mL using 6-deuterated m
Externí odkaz:
https://doaj.org/article/8431ee4b99bd46bab864944b4a179af1
Autor:
Fabian Rose, Beate Köberle, Sebastian Honnen, Cindy Bay, Jürgen Burhenne, Johanna Weiss, Walter E. Haefeli, Dirk Theile
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 173, Iss , Pp 116450- (2024)
Cisplatin not only targets DNA but also RNA. However, it is largely unknown whether platinated RNA (Pt-RNA) causes apoptosis and thus contributes to the cytotoxic effects of cisplatin. Consequently, cellular RNA was isolated from HepG2 and LS180 cell
Externí odkaz:
https://doaj.org/article/691ee0e015794113952a9066ccf52ae9
Autor:
Hatem A. Wafa, Iain Marshall, Charles D.A. Wolfe, Wanqing Xie, Catherine O. Johnson, Roland Veltkamp, Yanzhong Wang, Kirsten H. Harvey, Eleni Korompoki, Lucio D’Anna, Omid Halse, Emily R. Harvey, Klemens Hügen, Uwe Malzahn, Sabine Ullmann, Carolin Schuhmann, Gabriele Putz Todd, Hannes Brinz, Cornelia Fiessler, Peter U. Heuschmann, Kirsten Haas, Viktoria Rücker, Christian Enzinger, Stefan Ropele, Daniela Pinter, Melanie Haidegger, Thomas Gattringer, Simon Fandler-Höfler, Joan Montaner, Elena Palà, Anna Penalba, Marcel Lamana Vallverdu, Daisy Guaman Pilco, Stéphanie Debette, Igor Sibon, Pauline Renou, Morgane Lachaize, Léa Milan, Nathalie Heyvang, Sylvain Ledure, Pascale Michel, Johanna Conhoc, Léa Donnadieu, Kelly Hyves, Valeria Caso, Maria Giulia Mosconi, Mara Graziani, Virginia Cancelloni, Laura Marchini, Bianca Emanuela Koehler, Peter Brønnum Nielsen, Torben Bjerregaard Larsen, Gregory Y.H. Lip, Solveigh Horstmann, Jan Purrucker, Peter Ringleb, Mariam Haffa, Sabrina Klein, Lenka Taylor, Torsten Hoppe-Tichy, Walter E. Haefeli, Hanna M. Seidling, Jürgen Burhenne, Kathrin I. Foerster, Viktoria Wurmbach, Claudia Marquart, Deirdre A. Lane, Elena Ivany, Robyn Lotto
Publikováno v:
The Lancet Regional Health. Europe, Vol 38, Iss , Pp 100842- (2024)
Summary: Background: Anticipating the burden of intracerebral haemorrhage is crucial for proactive management and building resilience against future health challenges. Prior forecasts are based on population demography and to a lesser extent epidemio
Externí odkaz:
https://doaj.org/article/6f48fc103cc3458aba56509aad0fbadf
Autor:
Max Sauter, Jonas Haag, Cindy Bay, Florian Leuschner, Walter E. Haefeli, Tim Christian Kuhn, Jürgen Burhenne
Publikováno v:
Pharmaceutics, Vol 15, Iss 12, p 2745 (2023)
The calcium-dependent serine endoprotease PACE4 is evaluated as a therapeutic target for prostate cancer. The peptide Ac-[d-Leu]LLLRVK-amba inhibits PACE4 with high affinity and has shown efficacy in preclinical mice xenograft models of prostate canc
Externí odkaz:
https://doaj.org/article/da9826cd68554d59b8930fb0e8585ed5
Autor:
Vanessa Zhu, Jürgen Burhenne, Johanna Weiss, Mathias Haag, Ute Hofmann, Matthias Schwab, Stephan Urban, Gerd Mikus, David Czock, Walter E. Haefeli, Antje Blank
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Introduction: Bulevirtide is a first-in-class antiviral drug to treat chronic hepatitis B/D. We investigated the drug-drug interaction potential and pharmacokinetics of high-dose subcutaneous bulevirtide (5 mg twice daily) with organic anion transpor
Externí odkaz:
https://doaj.org/article/9dadd7a5884e42199ebe15eb6e6fa246
Autor:
Timolaos Rizos, Andreas D. Meid, Andrea Huppertz, Chris Dumschat, Jan Purrucker, Kathrin I. Foerster, Jürgen Burhenne, David Czock, Ekkehart Jenetzky, Peter A. Ringleb, Walter E. Haefeli
Publikováno v:
Journal of Stroke, Vol 24, Iss 1, Pp 88-97 (2022)
Background and purpose In acute stroke patients, plasma concentrations of direct oral anticoagulants (DOAC) at hospital admission only poorly mirror DOAC exposure or the coagulation status at the time of the event. Here, we evaluated whether DOAC exp
Externí odkaz:
https://doaj.org/article/86edab435408461b9a19d53330cd6373
Autor:
Nicolas Hohmann, Farastuk Bozorgmehr, Petros Christopoulos, Gerd Mikus, Antje Blank, Jürgen Burhenne, Michael Thomas, Walter E. Haefeli
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 2, Pp 487-491 (2021)
The inhibitor of anaplastic lymphoma kinase (ALK) crizotinib significantly increases survival in patients with ALK‐positive non‐small cell lung cancer (NSCLC). When evaluating crizotinib pharmacokinetics (PKs) in patients taking the standard flat
Externí odkaz:
https://doaj.org/article/c3263b190a004989afea2f5553ef2b93
Autor:
Margaux Fresnais, Rémi Longuespée, Max Sauter, Torsten Schaller, Michaela Arndt, Jürgen Krauss, Antje Blank, Walter E. Haefeli, Jürgen Burhenne
Publikováno v:
ACS Omega, Vol 5, Iss 38, Pp 24329-24339 (2020)
Externí odkaz:
https://doaj.org/article/e7c9c27da8eb4f9089f3fc091dd9fb20