M09 Myostatin Inhibition as a Novel Approach to Targeting Muscle Pathology in HD

Autor: Hayley Lazell, Tobias C. Wood, Ignacio Munoz-Sanjuan, Se-Jin Lee, Agnesska C. Benjamin, Linda Greensmith, David Howland, D Goodwin, A Lehar, X Chang, Mhoriam Ahmed, Ivan Rattray, Marie K. Bondulich, Georgina F. Osborne, Jrt Dick, Sophie A. Franklin, Nelly Jolinon, GP Bates, Michal Mielcarek, Donna L. Smith

Publikováno v: Journal of Neurology, Neurosurgery & Psychiatry. 85:A97-A97

Muscle atrophy is a well-documented symptom of Huntington’s disease (HD) and there are multiple lines of evidence to support a muscle-based pathology in HD patients and in mouse models of HD. Inhibition of the myostatin signalling pathway has been

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fb949819b6109e97f5ace599695a6c2b
https://doi.org/10.1136/jnnp-2014-309032.281

Myostatin inhibition prevents skeletal muscle pathophysiology in Huntington's disease mice.

Autor: Bondulich MK; Sobell Department of Motor Neuroscience and Movement Disorders, University College London Institute of Neurology, London, WC1N 3BG, UK.; Department Medical and Molecular Genetics, King's College London, London, SE1 9RT, UK.; Huntington's Disease Centre, UCL Institute of Neurology, London, WC1N 3BG, UK., Jolinon N; Department Medical and Molecular Genetics, King's College London, London, SE1 9RT, UK., Osborne GF; Sobell Department of Motor Neuroscience and Movement Disorders, University College London Institute of Neurology, London, WC1N 3BG, UK.; Department Medical and Molecular Genetics, King's College London, London, SE1 9RT, UK.; Huntington's Disease Centre, UCL Institute of Neurology, London, WC1N 3BG, UK., Smith EJ; Sobell Department of Motor Neuroscience and Movement Disorders, University College London Institute of Neurology, London, WC1N 3BG, UK.; Department Medical and Molecular Genetics, King's College London, London, SE1 9RT, UK.; Huntington's Disease Centre, UCL Institute of Neurology, London, WC1N 3BG, UK., Rattray I; Department Medical and Molecular Genetics, King's College London, London, SE1 9RT, UK., Neueder A; Sobell Department of Motor Neuroscience and Movement Disorders, University College London Institute of Neurology, London, WC1N 3BG, UK.; Department Medical and Molecular Genetics, King's College London, London, SE1 9RT, UK.; Huntington's Disease Centre, UCL Institute of Neurology, London, WC1N 3BG, UK., Sathasivam K; Sobell Department of Motor Neuroscience and Movement Disorders, University College London Institute of Neurology, London, WC1N 3BG, UK.; Department Medical and Molecular Genetics, King's College London, London, SE1 9RT, UK.; Huntington's Disease Centre, UCL Institute of Neurology, London, WC1N 3BG, UK., Ahmed M; Sobell Department of Motor Neuroscience and Movement Disorders, University College London Institute of Neurology, London, WC1N 3BG, UK.; MRC Centre for Neuromuscular Diseases, UCL Institute of Neurology, London, WC1N 3BG, UK., Ali N; Sobell Department of Motor Neuroscience and Movement Disorders, University College London Institute of Neurology, London, WC1N 3BG, UK.; Department Medical and Molecular Genetics, King's College London, London, SE1 9RT, UK.; Huntington's Disease Centre, UCL Institute of Neurology, London, WC1N 3BG, UK., Benjamin AC; Sobell Department of Motor Neuroscience and Movement Disorders, University College London Institute of Neurology, London, WC1N 3BG, UK.; Department Medical and Molecular Genetics, King's College London, London, SE1 9RT, UK.; Huntington's Disease Centre, UCL Institute of Neurology, London, WC1N 3BG, UK., Chang X; Department Molecular Biology and Genetics, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA., Dick JRT; Sobell Department of Motor Neuroscience and Movement Disorders, University College London Institute of Neurology, London, WC1N 3BG, UK.; MRC Centre for Neuromuscular Diseases, UCL Institute of Neurology, London, WC1N 3BG, UK., Ellis M; Division of Neuropathology, UCL Institute of Neurology, London, WC1N 3BG, UK.; Department of Neurodegenerative disease, UCL Institute of Neurology, London, WC1N 3BG, UK., Franklin SA; Sobell Department of Motor Neuroscience and Movement Disorders, University College London Institute of Neurology, London, WC1N 3BG, UK.; Department Medical and Molecular Genetics, King's College London, London, SE1 9RT, UK.; Huntington's Disease Centre, UCL Institute of Neurology, London, WC1N 3BG, UK., Goodwin D; Sobell Department of Motor Neuroscience and Movement Disorders, University College London Institute of Neurology, London, WC1N 3BG, UK.; Department Medical and Molecular Genetics, King's College London, London, SE1 9RT, UK.; Huntington's Disease Centre, UCL Institute of Neurology, London, WC1N 3BG, UK., Inuabasi L; Department Medical and Molecular Genetics, King's College London, London, SE1 9RT, UK., Lazell H; Sobell Department of Motor Neuroscience and Movement Disorders, University College London Institute of Neurology, London, WC1N 3BG, UK.; Department Medical and Molecular Genetics, King's College London, London, SE1 9RT, UK.; Huntington's Disease Centre, UCL Institute of Neurology, London, WC1N 3BG, UK., Lehar A; Department Molecular Biology and Genetics, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA., Richard-Londt A; Division of Neuropathology, UCL Institute of Neurology, London, WC1N 3BG, UK.; Department of Neurodegenerative disease, UCL Institute of Neurology, London, WC1N 3BG, UK., Rosinski J; CHDI Management/CHDI Foundation Inc, New York, NY, 10001, USA., Smith DL; Department Medical and Molecular Genetics, King's College London, London, SE1 9RT, UK., Wood T; Department of Neuroimaging, King's College London, Institute of Psychiatry, London, SE5 8AF, UK., Tabrizi SJ; Huntington's Disease Centre, UCL Institute of Neurology, London, WC1N 3BG, UK.; Department of Neurodegenerative disease, UCL Institute of Neurology, London, WC1N 3BG, UK., Brandner S; Division of Neuropathology, UCL Institute of Neurology, London, WC1N 3BG, UK.; Department of Neurodegenerative disease, UCL Institute of Neurology, London, WC1N 3BG, UK., Greensmith L; Sobell Department of Motor Neuroscience and Movement Disorders, University College London Institute of Neurology, London, WC1N 3BG, UK.; MRC Centre for Neuromuscular Diseases, UCL Institute of Neurology, London, WC1N 3BG, UK., Howland D; CHDI Management/CHDI Foundation Inc, New York, NY, 10001, USA., Munoz-Sanjuan I; CHDI Management/CHDI Foundation Inc, New York, NY, 10001, USA., Lee SJ; Department Molecular Biology and Genetics, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA., Bates GP; Sobell Department of Motor Neuroscience and Movement Disorders, University College London Institute of Neurology, London, WC1N 3BG, UK. gillian.bates@ucl.ac.uk.; Department Medical and Molecular Genetics, King's College London, London, SE1 9RT, UK. gillian.bates@ucl.ac.uk.; Huntington's Disease Centre, UCL Institute of Neurology, London, WC1N 3BG, UK. gillian.bates@ucl.ac.uk.

Publikováno v: Scientific reports [Sci Rep] 2017 Oct 27; Vol. 7 (1), pp. 14275. Date of Electronic Publication: 2017 Oct 27.