Elevated hydrostatic pressure enhances the motility and enlarges the size of the lung cancer cells through aquaporin upregulation mediated by caveolin-1 and ERK1/2 signaling

Autor: Jr Jheng, HJ Pan, WY Liao, YC Kao, Po-Ling Kuo, Chau-Hwang Lee

Publikováno v: Oncogene. 36(6)

The mechanical characteristics presented in cancer microenvironment are known to have pivotal roles in cancer metastasis, which accounts for the leading cause of death from malignant tumors. However, while a uniformly distributed high interstitial fl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b89f3e8f76dbc801a9beeb5d48ec929
https://pubmed.ncbi.nlm.nih.gov/27499095

Deficiency of the Deubiquitinase UCHL1 Attenuates Pulmonary Arterial Hypertension.

Autor: Tang H; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Department of Clinical Laboratory, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China (H.T., C.B., S.L.)., Gupta A; Department of Medicine and Arizona Health Sciences Center, Department of Cellular and Molecular Medicine, College of Medicine-Tucson, University of Arizona (A.G., G.G., N.A.W.)., Morrisroe SA; Krannert Cardiovascular Research Center (S.A.M., S.S., Y. Shi, S.R.N., S.C.-Y., R.D., A.A.D.), Indiana University, Indianapolis., Bao C; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Department of Clinical Laboratory, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China (H.T., C.B., S.L.).; College of Veterinary Medicine, Northwest A & F University, Yangling, China (C.B., Y. Sun, A.L., Y. Shi)., Schwantes-An TH; Department of Medicine, and Departments of Medical & Molecular Genetics (T.-H.S.-A.), Indiana University, Indianapolis., Gupta G; Department of Medicine and Arizona Health Sciences Center, Department of Cellular and Molecular Medicine, College of Medicine-Tucson, University of Arizona (A.G., G.G., N.A.W.)., Liang S; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Department of Clinical Laboratory, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China (H.T., C.B., S.L.)., Sun Y; College of Veterinary Medicine, Northwest A & F University, Yangling, China (C.B., Y. Sun, A.L., Y. Shi)., Chu A; Department of Echocardiography, Gansu Provincial Hospital, Lanzhou, China (A.C.)., Luo A; College of Veterinary Medicine, Northwest A & F University, Yangling, China (C.B., Y. Sun, A.L., Y. Shi).; Institute of Zoology, Guangdong Academy of Sciences, Guangzhou, China (A.L.)., Ramamoorthi Elangovan V; Department of Pediatrics, University of Michigan, Ann Arbor (V.R.E.)., Sangam S; Krannert Cardiovascular Research Center (S.A.M., S.S., Y. Shi, S.R.N., S.C.-Y., R.D., A.A.D.), Indiana University, Indianapolis., Shi Y; Krannert Cardiovascular Research Center (S.A.M., S.S., Y. Shi, S.R.N., S.C.-Y., R.D., A.A.D.), Indiana University, Indianapolis.; College of Veterinary Medicine, Northwest A & F University, Yangling, China (C.B., Y. Sun, A.L., Y. Shi)., Naidu SR; Krannert Cardiovascular Research Center (S.A.M., S.S., Y. Shi, S.R.N., S.C.-Y., R.D., A.A.D.), Indiana University, Indianapolis., Jheng JR; Division of Pulmonary, Critical Care, Sleep and Occupational Medicine (J.-R.J., Y.-C.L.), Indiana University, Indianapolis., Ciftci-Yilmaz S; Krannert Cardiovascular Research Center (S.A.M., S.S., Y. Shi, S.R.N., S.C.-Y., R.D., A.A.D.), Indiana University, Indianapolis., Warfel NA; Department of Medicine and Arizona Health Sciences Center, Department of Cellular and Molecular Medicine, College of Medicine-Tucson, University of Arizona (A.G., G.G., N.A.W.)., Hecker L; Department of Medicine, Emory University, and Atlanta VA Healthcare System, GA (L.H.)., Mitra S; Department of Obstetrics and Gynecology (S.M.), Department of Medicine, Washington University in St. Louis and John Cochran VA Hospital, St Louis, MO (A.J.)., Coleman AW; Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, OH (A.W.C., K.A.L., M.W.P., W.C.N.)., Lutz KA; Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, OH (A.W.C., K.A.L., M.W.P., W.C.N.)., Pauciulo MW; Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, OH (A.W.C., K.A.L., M.W.P., W.C.N.)., Lai YC; Division of Pulmonary, Critical Care, Sleep and Occupational Medicine (J.-R.J., Y.-C.L.), Indiana University, Indianapolis., Javaheri A; Department of Obstetrics and Gynecology (S.M.), Department of Medicine, Washington University in St. Louis and John Cochran VA Hospital, St Louis, MO (A.J.)., Dharmakumar R; Krannert Cardiovascular Research Center (S.A.M., S.S., Y. Shi, S.R.N., S.C.-Y., R.D., A.A.D.), Indiana University, Indianapolis., Wu WH; Department of Medicine, Institut Universitaire de Cardiologie et de Pneumologie de Québec, Université Laval, Quebec, Canada (W.-H.W., S.B.-B., O.B., S.B.)., Flaherty DP; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, Lafayette, IN (D.P.F.)., Karnes JH; Department of Pharmacy Practice and Science, R Ken Coit College of Pharmacy, University of Arizona, Tucson (J.H.K.)., Breuils-Bonnet S; Department of Medicine, Institut Universitaire de Cardiologie et de Pneumologie de Québec, Université Laval, Quebec, Canada (W.-H.W., S.B.-B., O.B., S.B.)., Boucherat O; Department of Medicine, Institut Universitaire de Cardiologie et de Pneumologie de Québec, Université Laval, Quebec, Canada (W.-H.W., S.B.-B., O.B., S.B.)., Bonnet S; Department of Medicine, Institut Universitaire de Cardiologie et de Pneumologie de Québec, Université Laval, Quebec, Canada (W.-H.W., S.B.-B., O.B., S.B.)., Yuan JX; Department of Medicine, University of California, San Diego, La Jolla (J.X.-J.Y.)., Jacobson JR; Department of Medicine, University of Illinois at Chicago (J.R.J.)., Duarte JD; Center for Pharmacogenomics and Precision Medicine, Department of Pharmacotherapy and Translational Research, University of Florida, Gainesville (J.D.D.)., Nichols WC; Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, OH (A.W.C., K.A.L., M.W.P., W.C.N.)., Garcia JGN; The Herbert Wertheim UF Scripps Institute for Biomedical Innovation and Technology, University of Florida, Jupiter (J.G.N.G.)., Desai AA; Krannert Cardiovascular Research Center (S.A.M., S.S., Y. Shi, S.R.N., S.C.-Y., R.D., A.A.D.), Indiana University, Indianapolis.

Publikováno v: Circulation [Circulation] 2024 Jul 23; Vol. 150 (4), pp. 302-316. Date of Electronic Publication: 2024 May 02.

Rosmarinic acid interferes with influenza virus A entry and replication by decreasing GSK3β and phosphorylated AKT expression levels.

Autor: Jheng JR; Department of Biochemistry and Molecular Biology, College of Medicine, Chang Gung University, Kweishan, Taoyuan 333, Taiwan; Division of Pulmonary, Critical Care, Sleep and Occupational Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA., Hsieh CF; Research Center for Emerging Viral Infections, Chang Gung University, Kweishan, Taoyuan 333, Taiwan., Chang YH; National Defense Medical Center, Institute of Preventive Medicine, Taipei 104, Taiwan., Ho JY; Department of Biochemistry and Molecular Biology, College of Medicine, Chang Gung University, Kweishan, Taoyuan 333, Taiwan., Tang WF; Research Center for Emerging Viral Infections, Chang Gung University, Kweishan, Taoyuan 333, Taiwan., Chen ZY; Department of Biochemistry and Molecular Biology, College of Medicine, Chang Gung University, Kweishan, Taoyuan 333, Taiwan., Liu CJ; Department of Biochemistry and Molecular Biology, College of Medicine, Chang Gung University, Kweishan, Taoyuan 333, Taiwan., Lin TJ; Department of Biochemistry and Molecular Biology, College of Medicine, Chang Gung University, Kweishan, Taoyuan 333, Taiwan., Huang LY; Department of Biochemistry and Molecular Biology, College of Medicine, Chang Gung University, Kweishan, Taoyuan 333, Taiwan., Chern JH; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan, Miaoli 350, Taiwan., Horng JT; Department of Biochemistry and Molecular Biology, College of Medicine, Chang Gung University, Kweishan, Taoyuan 333, Taiwan; Research Center for Emerging Viral Infections, Chang Gung University, Kweishan, Taoyuan 333, Taiwan; Molecular Infectious Disease Research Center, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan 333, Taiwan; Research Center for Food and Cosmetic Safety, Graduate Institute of Health Industry Technology, Chang Gung University of Science and Technology, Taoyuan 333, Taiwan. Electronic address: jimtong@mail.cgu.edu.tw.

Publikováno v: Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi [J Microbiol Immunol Infect] 2022 Aug; Vol. 55 (4), pp. 598-610. Date of Electronic Publication: 2022 May 18.

Perilla (Perilla frutescens) leaf extract inhibits SARS-CoV-2 via direct virus inactivation.

Autor: Tang WF; Research Center for Emerging Viral Infections, College of Medicine, Chang Gung University, Kweishan, Taoyuan, Taiwan., Tsai HP; Institute of Preventive Medicine, National Defense Medical Center, Taipei, Taiwan., Chang YH; Institute of Preventive Medicine, National Defense Medical Center, Taipei, Taiwan., Chang TY; Institute of Preventive Medicine, National Defense Medical Center, Taipei, Taiwan., Hsieh CF; Research Center for Emerging Viral Infections, College of Medicine, Chang Gung University, Kweishan, Taoyuan, Taiwan., Lin CY; Research Center for Emerging Viral Infections, College of Medicine, Chang Gung University, Kweishan, Taoyuan, Taiwan., Lin GH; Research Center for Emerging Viral Infections, College of Medicine, Chang Gung University, Kweishan, Taoyuan, Taiwan., Chen YL; Research Center for Industry of Human Ecology and Research Center for Chinese Herbal Medicine, Graduate Institute of Health Industry Technology, Chang Gung University of Science and Technology, Taoyuan, Taiwan; Department of Biochemistry and Molecular Biology, College of Medicine, Chang Gung University, Kweishan, Taoyuan, Taiwan., Jheng JR; Department of Biochemistry and Molecular Biology, College of Medicine, Chang Gung University, Kweishan, Taoyuan, Taiwan., Liu PC; Institute of Preventive Medicine, National Defense Medical Center, Taipei, Taiwan., Yang CM; Institute of Preventive Medicine, National Defense Medical Center, Taipei, Taiwan., Chin YF; Institute of Preventive Medicine, National Defense Medical Center, Taipei, Taiwan., Chen CC; Institute of Preventive Medicine, National Defense Medical Center, Taipei, Taiwan; Graduate Institute of Medical Science, National Defense Medical Center, Taipei, Taiwan., Kau JH; Institute of Preventive Medicine, National Defense Medical Center, Taipei, Taiwan., Hung YJ; Institute of Preventive Medicine, National Defense Medical Center, Taipei, Taiwan., Hsieh PS; Institute of Preventive Medicine, National Defense Medical Center, Taipei, Taiwan., Horng JT; Research Center for Emerging Viral Infections, College of Medicine, Chang Gung University, Kweishan, Taoyuan, Taiwan; Research Center for Industry of Human Ecology and Research Center for Chinese Herbal Medicine, Graduate Institute of Health Industry Technology, Chang Gung University of Science and Technology, Taoyuan, Taiwan; Department of Biochemistry and Molecular Biology, College of Medicine, Chang Gung University, Kweishan, Taoyuan, Taiwan; Molecular Infectious Disease Research Center, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan. Electronic address: jimtong@mail.cgu.edu.tw.

Publikováno v: Biomedical journal [Biomed J] 2021 Jun; Vol. 44 (3), pp. 293-303. Date of Electronic Publication: 2021 Jan 28.

Rosmarinic acid exhibits broad anti-enterovirus A71 activity by inhibiting the interaction between the five-fold axis of capsid VP1 and cognate sulfated receptors.

Autor: Hsieh CF; Department of Biochemistry and Molecular Biology, College of Medicine, Chang Gung University, Taoyuan, Taiwan., Jheng JR; Department of Biochemistry and Molecular Biology, College of Medicine, Chang Gung University, Taoyuan, Taiwan., Lin GH; Department of Biochemistry and Molecular Biology, College of Medicine, Chang Gung University, Taoyuan, Taiwan., Chen YL; Department of Biochemistry and Molecular Biology, College of Medicine, Chang Gung University, Taoyuan, Taiwan., Ho JY; Department of Biochemistry and Molecular Biology, College of Medicine, Chang Gung University, Taoyuan, Taiwan., Liu CJ; Department of Biochemistry and Molecular Biology, College of Medicine, Chang Gung University, Taoyuan, Taiwan., Hsu KY; Department of Biochemistry and Molecular Biology, College of Medicine, Chang Gung University, Taoyuan, Taiwan., Chen YS; Genomics Research Center, Academia Sinica, Taipei, Taiwan., Chan YF; Department of Medical Microbiology, University Malaya, Kuala Lumpur, Malaysia., Yu HM; Genomics Research Center, Academia Sinica, Taipei, Taiwan., Hsieh PW; Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan, Taiwan.; Research Center for Industry of Human Ecology and Graduate Institute of Health Industry Technology, Chang Gung University of Science and Technology, Taoyuan, Taiwan.; Department of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan, Taiwan., Chern JH; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan, Taiwan, ROC., Horng JT; Department of Biochemistry and Molecular Biology, College of Medicine, Chang Gung University, Taoyuan, Taiwan.; Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan, Taiwan.; Research Center for Emerging Viral Infections and Healthy Aging Research Center, College of Medicine, Chang Gung University, Taoyuan, Taiwan.; Molecular Infectious Disease Research Center, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan.

Publikováno v: Emerging microbes & infections [Emerg Microbes Infect] 2020 Dec; Vol. 9 (1), pp. 1194-1205.