HSD3B1 genotype identifies glucocorticoid responsiveness in severe asthma

Autor: Stephen P. Peters, David T. Mauger, E. Israel, W. G. Teague, Peter Bazeley, Bruce D. Levy, Sally E. Wenzel, Mohammad Alyamani, Jr Igo Rp, Nima Sharifi, Nizar N. Jarjour, B.M. Gaston, K.F. Chung, Deborah A. Meyers, Ortega, Nadzeya Marozkina, Serpil C. Erzurum, Mario Castro, G.A. Hawkins, Wendy C. Moore, Calvin Cotton, Eugene R. Bleecker, John V. Fahy, DeBoer, William J. Calhoun, Anne M. Fitzpatrick, William W. Busse, Xu W, Manesh R. Patel, Patricia Noel, Joe Zein, Suzy A. A. Comhair

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, vol 117, iss 4
Proceedings of the National Academy of Sciences of the United States of America

Significance Although resistance to glucocorticoids is a major clinical problem, the underlying mechanisms are unknown. It is known that glucocorticoid use can suppress adrenal androgen production. In population studies, animal models, and cell cultu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30163713b2aea945a7cce53304d8a430
https://doi.org/10.1073/pnas.1918819117