Evidence that the MCC-APC gene region in 5q21 is not the site for susceptibility to hereditary nonpolyposis colorectal carcinoma

Autor: Peltomäki P, Sistonen P, Jp, Mecklin, Pylkkänen L, Aaltonen L, Nordling S, Juha Kere, Järvinen H, Sr, Hamilton, Petersen G

Publikováno v: Europe PubMed Central

Hereditary nonpolyposis colorectal carcinoma (HNPCC) is the most common form of hereditary colon cancer. Autosomal dominant inheritance is evident from pedigrees but the genetic basis of the disorder is otherwise unknown. Recently, two genes in 5q21

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::a72ecbe6e24a0cde8a35df6ed1131e82
https://pubmed.ncbi.nlm.nih.gov/1643645

EXO1 variants occur commonly in normal population: evidence against a role in hereditary nonpolyposis colorectal cancer

Autor: Jagmohan-Changur S, Poikonen T, Vilkki S, Launonen V, Wikman F, Tf, Orntoft, Møller P, Hans Vasen, Tops C, Rd, Kolodner, Jp, Mecklin, Järvinen H, Bevan S, Karhu A

Publikováno v: Europe PubMed Central

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::61036dc2dbba3b04cbfd5fef14026342
http://europepmc.org/abstract/med/12517792

Lynch syndrome-associated and sporadic microsatellite unstable colorectal cancers: different patterns of clonal evolution yield highly similar tumours.

Autor: Martin S; Medicum/Department of Medical and Clinical Genetics, University of Helsinki, Haartmaninkatu 8, 00014 Helsinki, Finland.; Applied Tumor Genomics Research Program, Research Programs Unit, University of Helsinki, Haartmaninkatu 8, 00014 Helsinki, Finland., Katainen R; Medicum/Department of Medical and Clinical Genetics, University of Helsinki, Haartmaninkatu 8, 00014 Helsinki, Finland.; Applied Tumor Genomics Research Program, Research Programs Unit, University of Helsinki, Haartmaninkatu 8, 00014 Helsinki, Finland., Taira A; Medicum/Department of Medical and Clinical Genetics, University of Helsinki, Haartmaninkatu 8, 00014 Helsinki, Finland.; Applied Tumor Genomics Research Program, Research Programs Unit, University of Helsinki, Haartmaninkatu 8, 00014 Helsinki, Finland., Välimäki N; Medicum/Department of Medical and Clinical Genetics, University of Helsinki, Haartmaninkatu 8, 00014 Helsinki, Finland.; Applied Tumor Genomics Research Program, Research Programs Unit, University of Helsinki, Haartmaninkatu 8, 00014 Helsinki, Finland., Ristimäki A; Applied Tumor Genomics Research Program, Research Programs Unit, University of Helsinki, Haartmaninkatu 8, 00014 Helsinki, Finland.; Department of Pathology, HUSLAB, HUS Diagnostic Center, University of Helsinki and Helsinki University Hospital, Haartmaninkatu 3, 00290 Helsinki, Finland., Seppälä T; Applied Tumor Genomics Research Program, Research Programs Unit, University of Helsinki, Haartmaninkatu 8, 00014 Helsinki, Finland.; Department of Surgery, Helsinki University Central Hospital, Hospital District of Helsinki and Uusimaa, Haartmaninkatu 4, 00290 Helsinki, Finland.; Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital and TAYS Cancer Centre, Kuntokatu 2, 33520 Tampere, Finland.; Faculty of Medicine and Health Technology, Tampere University, Kalevantie 4, 33100 Tampere, Finland.; iCAN Digital Precision Cancer Medicine Flagship, University of Helsinki, Haartmaninkatu 8, 00014 Helsinki, Finland., Renkonen-Sinisalo L; Applied Tumor Genomics Research Program, Research Programs Unit, University of Helsinki, Haartmaninkatu 8, 00014 Helsinki, Finland.; Department of Surgery, Helsinki University Central Hospital, Hospital District of Helsinki and Uusimaa, Haartmaninkatu 4, 00290 Helsinki, Finland., Lepistö A; Applied Tumor Genomics Research Program, Research Programs Unit, University of Helsinki, Haartmaninkatu 8, 00014 Helsinki, Finland.; Department of Surgery, Helsinki University Central Hospital, Hospital District of Helsinki and Uusimaa, Haartmaninkatu 4, 00290 Helsinki, Finland., Tahkola K; Faculty of Medicine and Health Technology, Tampere University, Kalevantie 4, 33100 Tampere, Finland.; Department of Surgery, Central Finland Health Care District, Keskussairaalantie 19, 40620 Jyväskylä, Finland., Mattila A; Department of Surgery, Central Finland Health Care District, Keskussairaalantie 19, 40620 Jyväskylä, Finland., Koskensalo S; The HUCH Gastrointestinal Clinic, Helsinki University Central Hospital, Stenbäckinkatu 9A, 00029 Helsinki, Finland., Mecklin JP; Department of Education and Research, The Wellbeing Services of Central Finland, Hoitajatie 1, 40620 Jyväskylä, Finland.; Department of Sport and Health Sciences, University of Jyväskylä, Seminaarinkatu 15, 40014 Jyväskylä, Finland., Rajamäki K; Medicum/Department of Medical and Clinical Genetics, University of Helsinki, Haartmaninkatu 8, 00014 Helsinki, Finland.; Applied Tumor Genomics Research Program, Research Programs Unit, University of Helsinki, Haartmaninkatu 8, 00014 Helsinki, Finland., Palin K; Medicum/Department of Medical and Clinical Genetics, University of Helsinki, Haartmaninkatu 8, 00014 Helsinki, Finland.; Applied Tumor Genomics Research Program, Research Programs Unit, University of Helsinki, Haartmaninkatu 8, 00014 Helsinki, Finland.; iCAN Digital Precision Cancer Medicine Flagship, University of Helsinki, Haartmaninkatu 8, 00014 Helsinki, Finland., Aaltonen LA; Medicum/Department of Medical and Clinical Genetics, University of Helsinki, Haartmaninkatu 8, 00014 Helsinki, Finland.; Applied Tumor Genomics Research Program, Research Programs Unit, University of Helsinki, Haartmaninkatu 8, 00014 Helsinki, Finland.; iCAN Digital Precision Cancer Medicine Flagship, University of Helsinki, Haartmaninkatu 8, 00014 Helsinki, Finland.

Publikováno v: Human molecular genetics [Hum Mol Genet] 2024 Nov 05; Vol. 33 (21), pp. 1858-1872.

Establishing Criteria for Tumor Necrosis as Prognostic Indicator in Colorectal Cancer.

Autor: Kastinen M; Translational Medicine Research Unit, Medical Research Center Oulu, Oulu University Hospital, and University of Oulu, Oulu., Sirniö P; Translational Medicine Research Unit, Medical Research Center Oulu, Oulu University Hospital, and University of Oulu, Oulu., Elomaa H; Department of Biological and Environmental Science, University of Jyväskylä, Jyväskylä.; Department of Education and Research, Central Finland Health Care District, Jyväskylä., Äijälä VK; Translational Medicine Research Unit, Medical Research Center Oulu, Oulu University Hospital, and University of Oulu, Oulu., Karjalainen H; Translational Medicine Research Unit, Medical Research Center Oulu, Oulu University Hospital, and University of Oulu, Oulu., Tapiainen VV; Translational Medicine Research Unit, Medical Research Center Oulu, Oulu University Hospital, and University of Oulu, Oulu., Pohjanen VM; Translational Medicine Research Unit, Medical Research Center Oulu, Oulu University Hospital, and University of Oulu, Oulu., Kemppainen J; Translational Medicine Research Unit, Medical Research Center Oulu, Oulu University Hospital, and University of Oulu, Oulu., Sliashynskaya K; Translational Medicine Research Unit, Medical Research Center Oulu, Oulu University Hospital, and University of Oulu, Oulu., Ahtiainen M; Department of Pathology, Central Finland Health Care District, Jyväskylä., Rintala J; Translational Medicine Research Unit, Medical Research Center Oulu, Oulu University Hospital, and University of Oulu, Oulu., Meriläinen S; Translational Medicine Research Unit, Medical Research Center Oulu, Oulu University Hospital, and University of Oulu, Oulu., Rautio T; Translational Medicine Research Unit, Medical Research Center Oulu, Oulu University Hospital, and University of Oulu, Oulu., Saarnio J; Translational Medicine Research Unit, Medical Research Center Oulu, Oulu University Hospital, and University of Oulu, Oulu., Mattila TT; Translational Medicine Research Unit, Medical Research Center Oulu, Oulu University Hospital, and University of Oulu, Oulu., Lindgren O; Translational Medicine Research Unit, Medical Research Center Oulu, Oulu University Hospital, and University of Oulu, Oulu., Wirta EV; Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere.; Faculty of Medicine and Health Technology, Tampere University and Tays Cancer Centre, Tampere University Hospital, Tampere., Helminen O; Translational Medicine Research Unit, Medical Research Center Oulu, Oulu University Hospital, and University of Oulu, Oulu., Seppälä TT; Faculty of Medicine and Health Technology, Tampere University and Tays Cancer Centre, Tampere University Hospital, Tampere.; Department of Gastrointestinal Surgery, Helsinki University Central Hospital, University of Helsinki, Helsinki.; Applied Tumor Genomics, Research Program Unit, University of Helsinki, Helsinki., Böhm J; Department of Pathology, Central Finland Health Care District, Jyväskylä., Mecklin JP; Department of Education and Research, Central Finland Health Care District, Jyväskylä.; Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland., Tuomisto A; Translational Medicine Research Unit, Medical Research Center Oulu, Oulu University Hospital, and University of Oulu, Oulu., Mäkinen MJ; Translational Medicine Research Unit, Medical Research Center Oulu, Oulu University Hospital, and University of Oulu, Oulu., Väyrynen JP; Translational Medicine Research Unit, Medical Research Center Oulu, Oulu University Hospital, and University of Oulu, Oulu.

Publikováno v: The American journal of surgical pathology [Am J Surg Pathol] 2024 Oct 01; Vol. 48 (10), pp. 1284-1292. Date of Electronic Publication: 2024 Jul 15.

Circulating miRNA Signature Predicts Cancer Incidence in Lynch Syndrome-A Pilot Study.

Autor: Sievänen T; Gerontology Research Center and Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland., Jokela T; Gerontology Research Center and Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland., Hyvärinen M; Gerontology Research Center and Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland., Korhonen TM; Gerontology Research Center and Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland., Pylvänäinen K; The wellbeing services county of Central Finland, Jyväskylä, Finland., Mecklin JP; The wellbeing services county of Central Finland, Jyväskylä, Finland.; Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland., Karvanen J; Department of Mathematics and Statistics, University of Jyväskylä, Jyväskylä, Finland., Sillanpää E; Gerontology Research Center and Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland.; The wellbeing services county of Central Finland, Jyväskylä, Finland., Seppälä TT; Applied Tumor Genomics Research Program, University of Helsinki, Helsinki, Finland.; Department of Abdominal Surgery, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.; Department of Gastroenterology and Alimentary Tract Surgery and TAYS Cancer Centre, Tampere University Hospital, Tampere, Finland.; Faculty of Medicine and Health Technology, University of Tampere, Tampere, Finland., Laakkonen EK; Gerontology Research Center and Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland.

Publikováno v: Cancer prevention research (Philadelphia, Pa.) [Cancer Prev Res (Phila)] 2024 Jun 04; Vol. 17 (6), pp. 243-254.