Evidence that the MCC-APC gene region in 5q21 is not the site for susceptibility to hereditary nonpolyposis colorectal carcinoma

Autor: Peltomäki P, Sistonen P, Jp, Mecklin, Pylkkänen L, Aaltonen L, Nordling S, Juha Kere, Järvinen H, Sr, Hamilton, Petersen G

Publikováno v: Europe PubMed Central

Hereditary nonpolyposis colorectal carcinoma (HNPCC) is the most common form of hereditary colon cancer. Autosomal dominant inheritance is evident from pedigrees but the genetic basis of the disorder is otherwise unknown. Recently, two genes in 5q21

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::a72ecbe6e24a0cde8a35df6ed1131e82
https://pubmed.ncbi.nlm.nih.gov/1643645

EXO1 variants occur commonly in normal population: evidence against a role in hereditary nonpolyposis colorectal cancer

Autor: Jagmohan-Changur S, Poikonen T, Vilkki S, Launonen V, Wikman F, Tf, Orntoft, Møller P, Hans Vasen, Tops C, Rd, Kolodner, Jp, Mecklin, Järvinen H, Bevan S, Karhu A

Publikováno v: Europe PubMed Central

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::61036dc2dbba3b04cbfd5fef14026342
http://europepmc.org/abstract/med/12517792

A "Two-in-One Hit" Model of Shortcut Carcinogenesis in MLH1 Lynch Syndrome Carriers.

Autor: Ahadova A; Department of Applied Tumor Biology, Institute of Pathology, Heidelberg University Hospital, Clinical Cooperation Unit Applied Tumor Biology, German Cancer Research Centre, Heidelberg, Germany., Stenzinger A; Institute of Pathology, Heidelberg University Hospital, German Cancer Consortium and German Cancer Research Center, Heidelberg, Germany., Seppälä T; Faculty of Medicine and Health Technology, Tampere University, Tays Cancer Center, Tampere University Hospital, Tampere, Finland; Applied Tumor Genomics Research Program, Department of Surgery, Abdominal Center, Helsinki University Hospital, Helsinki, Finland., Hüneburg R; National Center for Hereditary Tumor Syndromes, Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany., Kloor M; Department of Applied Tumor Biology, Institute of Pathology, Heidelberg University Hospital, Clinical Cooperation Unit Applied Tumor Biology, German Cancer Research Centre (DKFZ), Heidelberg, Germany. Electronic address: matthias.kloor@med.uni-heidelberg.de., Bläker H; Institute of Pathology, University Hospital Leipzig, Leipzig, Germany.

Publikováno v: Gastroenterology [Gastroenterology] 2023 Jul; Vol. 165 (1), pp. 267-270.e4. Date of Electronic Publication: 2023 Mar 11.

Survival of Colorectal Cancer in Patients With or Without Inflammatory Bowel Disease: A Meta-Analysis.

Autor: Ou, Baochi, Zhao, Jingkun, Guan, Shaopei, Lu, Aiguo

Publikováno v: Digestive Diseases & Sciences; Mar2016, Vol. 61 Issue 3, p881-889, 9p

PTEN Germline Mutations in Patients Initially Tested for Other Hereditary Cancer Syndromes: Would Use of Risk Assessment Tools Reduce Genetic Testing?

Autor: Mester, Jessica L., Moore, Rebekah A., Eng, Charis

Publikováno v: Oncologist; Oct2013, Vol. 18 Issue 10, p1083-1090, 8p, 5 Charts