An end is in sight: a perspective on PCR as an endpoint for Chagas disease treatment trials

Autor: Natasha S. Hochberg, Srinivasa P. S. Rao, Gerhild Angyalosi, Xiaojun Zhao, Leticia Carballo, Caroline Demacq, Sofia Braud-Perez, Daniela Wieser, JP Casas, John Millholland, Debby Ngo

Publikováno v: Frontiers in Parasitology, Vol 2 (2023)

Novel therapies for chronic indeterminate Chagas disease (CICD) are needed, but trials are limited by the absence of tests to detect infection and early treatment efficacy. This perspective highlights the shortfalls and strengths of polymerase chain

Externí odkaz: https://doaj.org/article/c24db153dd35483e96c775d1ff263e9e

291: Estimation of Bias in 'Mendelian Triangulation' Studies

Autor: AD Hingorani, L Smeeth, Leonelo E. Bautista, JP Casas

Publikováno v: American Journal of Epidemiology. 161:S73-S73

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e7dc1281124dda6a1806d690a1a800e5
https://doi.org/10.1093/aje/161.supplement_1.s73b

Mendelian randomization of blood lipids for coronary heart disease

Autor: Mv, Holmes, Fw, Asselbergs, Tm, Palmer, Drenos F, Matthew Lanktree, Cp, Nelson, Ce, Dale, Padmanabhan S, Finan C, Di, Swerdlow, Tragante V, Ep, Iperen, Sivapalaratnam S, Shah S, Cc, Elbers, Shah T, Engmann J, Giambartolomei C, White J, Zabaneh D, Sofat R, McLachlan S, Ucleb, On Behalf Of The Consortium, Pa, Doevendans, Aj, Balmforth, As, Hall, Ke, North, Almoguera B, Rc, Hoogeveen, Cushman M, Fornage M, Sr, Patel, Redline S, Ds, Siscovick, My, Tsai, Kj, Karczewski, Mh, Hofker, Wm, Verschuren, Ml, Bots, Yt, Schouw, Melander O, Af, Dominiczak, Morris R, Ben-Shlomo Y, Price J, Kumari M, Baumert J, Peters A, Thorand B, Koenig W, Tr, Gaunt, Se, Humphries, Clarke R, Watkins H, Farrall M, Jg, Wilson, Ss, Rich, Pi, Bakker, La, Lange, Davey Smith G, Ap, Reiner, Pj, Talmud, Kivimäki M, Da, Lawlor, Dudbridge F, Nj, Samani, Bj, Keating, Ad, Hingorani, Jp, Casas

Publikováno v: Europe PubMed Central

AIMS: To investigate the causal role of high-density lipoprotein cholesterol (HDL-C) and triglycerides in coronary heart disease (CHD) using multiple instrumental variables for Mendelian randomization. METHODS AND RESULTS: We developed weighted allel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::a42e99ce2da667b07d5937083302518b
http://europepmc.org/abstract/med/24474739

Estimating the Effect of Bariatric Surgery on Cardiovascular Events Using Observational Data?

Autor: Madenci AL; From the CAUSALab, Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA.; Boston Children's Hospital and Harvard Medical School, Boston, MA., Kurgansky KE; Veterans Affairs Boston Healthcare System, Boston, MA., Dickerman BA; From the CAUSALab, Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA., Gerlovin H; Veterans Affairs Boston Healthcare System, Boston, MA., Wanis KN; From the CAUSALab, Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA.; Department of Surgery, Western University, London, ON., Smith AD; Veterans Affairs Boston Healthcare System, Boston, MA., Trinquart L; Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA.; Tufts Clinical and Translational Science Institute, Tufts University, Boston, MA., Gagnon DR; Veterans Affairs Boston Healthcare System, Boston, MA.; Boston University School of Public Health, Boston, MA., Cho K; Veterans Affairs Boston Healthcare System, Boston, MA., Gaziano JM; Veterans Affairs Boston Healthcare System, Boston, MA.; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA., Casas JP; Veterans Affairs Boston Healthcare System, Boston, MA., Robins JM; From the CAUSALab, Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA.; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA., Hernán MA; From the CAUSALab, Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA.; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA.

Publikováno v: Epidemiology (Cambridge, Mass.) [Epidemiology] 2024 Sep 01; Vol. 35 (5), pp. 721-729. Date of Electronic Publication: 2024 Jul 18.

Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.

Autor: Verma A; Corporal Michael Crescenz VA Medical Center, Philadelphia, PA 19104, USA.; Department of Medicine, Division of Translational Medicine and Human Genetics, University of Pennsylvania - Perelman School of Medicine, Philadelphia, PA 19104, USA.; Institute for Biomedical Informatics, University of Pennsylvania - Perelman School of Medicine, Philadelphia, PA 19104, USA., Huffman JE; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA 02130, USA.; Palo Alto Veterans Institute for Research (PAVIR), Palo Alto Health Care System, Palo Alto, CA 94304, USA.; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA., Rodriguez A; Data Science and Learning, Argonne National Laboratory, Lemont, IL 60439, USA., Conery M; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania - Perelman School of Medicine, Philadelphia, PA 19104, USA., Liu M; Department of Biostatistics, Columbia University's Mailman School of Public Health, New York, NY 10032, USA., Ho YL; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA 02130, USA., Kim Y; Mathematics and Computer Science Division, Argonne National Laboratory, Lemont, IL 60439, USA., Heise DA; National Security Sciences Directorate, Cyber Resilience and Intelligence Division, Oak Ridge National Laboratory, Dept of Energy, Oak Ridge, TN 37831, USA., Guare L; Department of Medicine, Division of Translational Medicine and Human Genetics, University of Pennsylvania - Perelman School of Medicine, Philadelphia, PA 19104, USA., Panickan VA; Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02115, USA., Garcon H; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA 02130, USA., Linares F; R&D Systems Engineering, Information Technology Services Directorate, Oak Ridge National Laboratory, Dept of Energy, Oak Ridge, TN 37831, USA., Costa L; MVP Boston Coordinating Center, VA Boston Healthcare System, Boston, MA 02111, USA., Goethert I; Data Management and Engineering, Information Technology Services Division, Oak Ridge National Laboratory, Dept of Energy, Oak Ridge, TN 37831, USA., Tipton R; Knowledge Discovery Infrastructure, Information Technology Services Division, Oak Ridge National Laboratory, Dept of Energy, Oak Ridge, TN 37831, USA., Honerlaw J; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA 02130, USA., Davies L; Computing and Computational Sciences Dir PMO, PMO, Oak Ridge National Laboratory, Dept of Energy, Oak Ridge, TN 37831, USA., Whitbourne S; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.; MVP Boston Coordinating Center, VA Boston Healthcare System, Boston, MA 02111, USA.; Department of Medicine, Division of Aging, Brigham and Women's Hospital, Boston, MA 02115, USA., Cohen J; National Security Sciences Directorate, Cyber Resilience and Intelligence Division, Oak Ridge National Laboratory, Dept of Energy, Oak Ridge, TN 37831, USA., Posner DC; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA 02130, USA., Sangar R; MVP Boston Coordinating Center, VA Boston Healthcare System, Boston, MA 02111, USA., Murray M; MVP Boston Coordinating Center, VA Boston Healthcare System, Boston, MA 02111, USA., Wang X; Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02115, USA.; Department of Population Health Sciences, University of Utah, Salt Lake City, UT 84112, USA., Dochtermann DR; VA Cooperative Studies Program, VA Boston Healthcare System, Boston, MA 02130, USA., Devineni P; VA Cooperative Studies Program, VA Boston Healthcare System, Boston, MA 02130, USA., Shi Y; VA Cooperative Studies Program, VA Boston Healthcare System, Boston, MA 02130, USA., Nandi TN; Data Science and Learning, Argonne National Laboratory, Lemont, IL 60439, USA., Assimes TL; Medicine, Cardiology, VA Palo Alto Healthcare System, Palo Alto, CA 94304, USA., Brunette CA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.; Research Service, VA Boston Healthcare System, Boston, MA 02130, USA., Carroll RJ; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN 37211, USA., Clifford R; Research Department, VA San Diego Healthcare System, San Diego, CA 92161, USA.; Department of Otolaryngology, UCSD San Diego, La Jolla, CA 92093, USA., Duvall S; VA Informatics and Computing Infrastructure, VA Salt Lake City Health Care System, Salt Lake City, UT 84148, USA.; Internal Medicine, Epidemiology, University of Utah School of Medicine, Salt Lake City, UT 84132, USA., Gelernter J; Psychiatry, Human Genetics, Yale University, New Haven, CT, 06520, USA.; VA Connecticut Healthcare System West Haven, West Haven, CT, 06516, USA., Hung A; Medicine, Nephrology & Hypertension, VA Tennessee Valley Healthcare System & Vanderbilt University, Nashville, TN 37232, USA., Iyengar SK; Departments of Population and Quantitative Health Sciences, Genetics and Genome Sciences, and Ophthalmology and Visual Sciences and the Cleveland Institute for Computational Biology, Case Western Reserve University, Cleveland, OH 44106, USA., Joseph J; Medicine, Cardiology Section, VA Providence Healthcare System, Providence, RI 02908, USA.; Department of Medicine, Brown University, Providence, RI, 02908, USA., Kember R; Mental Illness Research, Education and Clinical Center, Corporal Michael Crescenz VA Medical Center, Philadelphia, PA 19104, USA.; Department of Psychiatry, University of Pennsylvania - Perelman School of Medicine, Philadelphia, PA 19104, USA., Kranzler H; Mental Illness Research, Education and Clinical Center, Corporal Michael Crescenz VA Medical Center, Philadelphia, PA 19104, USA.; Department of Psychiatry, University of Pennsylvania - Perelman School of Medicine, Philadelphia, PA 19104, USA., Kripke CM; Department of Medicine, Division of Translational Medicine and Human Genetics, University of Pennsylvania - Perelman School of Medicine, Philadelphia, PA 19104, USA., Levey D; Psychiatry, Human Genetics, Yale University, New Haven, CT, 06520, USA.; Medicine, VA Connecticut Healthcare System West Haven, West Haven, CT 06516, USA., Luoh SW; VA Portland Health Care System, Portland, OR 97239, USA.; Division of Hematology and Medical Oncology, Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97239, USA., Merritt VC; Research Department, VA San Diego Healthcare System, San Diego, CA 92161, USA., Overstreet C; Psychiatry, Human Genetics, Yale University, New Haven, CT, 06520, USA., Deak JD; Psychiatry, Yale University, New Haven, CT 06520, USA.; Psychiatry, VA Connecticut Healthcare System West Haven, West Haven, CT 06516, USA., Grant SFA; Center for Spatial and Functional Genomics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Department of Pediatrics, University of Pennsylvania - Perelman School of Medicine, Philadelphia, PA 19104, USA.; Divisions of Human Genetics and Endocrinology and Diabetes, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Department of Genetics, University of Pennsylvania - Perelman School of Medicine, Philadelphia, PA 19104, USA., Polimanti R; Psychiatry, Yale University, New Haven, CT 06520, USA., Roussos P; Psychiatry, Mental Illness Research, Education and Clinical Center, James J. Peters VA Medical Center; Icahn School of Medicine at Mount Sinai, Bronx, NY 10468, USA., Shakt G; Corporal Michael Crescenz VA Medical Center, Philadelphia, PA 19104, USA.; Department of Surgery, University of Pennsylvania - Perelman School of Medicine, Philadelphia, PA 19104, USA., Sun YV; Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA 30322, USA., Tsao N; Corporal Michael Crescenz VA Medical Center, Philadelphia, PA 19104, USA.; Department of Surgery, University of Pennsylvania - Perelman School of Medicine, Philadelphia, PA 19104, USA., Venkatesh S; Psychiatry, Mental Illness Research, Education and Clinical Center, James J. Peters VA Medical Center; Icahn School of Medicine at Mount Sinai, Bronx, NY 10468, USA., Voloudakis G; Psychiatry, Mental Illness Research, Education and Clinical Center, James J. Peters VA Medical Center; Icahn School of Medicine at Mount Sinai, Bronx, NY 10468, USA., Justice A; Medicine, VA Connecticut Healthcare System West Haven, West Haven, CT 06516, USA.; Internal Medicine, General Medicine, Yale University, New Haven, CT 06520, USA.; Health Policy, Yale School of Public Health, New Haven, CT 06520, USA., Begoli E; Oak Ridge National Laboratory, Dept of Energy, Oak Ridge, TN, 37831, USA., Ramoni R; Office of Research and Development, Department of Veterans Affairs, Washington, DC, 20420, USA., Tourassi G; National Center for Computational Sciences, Oak Ridge National Laboratory, Dept of Energy, Oak Ridge, TN, 37831, USA., Pyarajan S; VA Cooperative Studies Program, VA Boston Healthcare System, Boston, MA 02130, USA., Tsao P; Medicine, Cardiology, VA Palo Alto Healthcare System, Palo Alto, CA 94304, USA.; Department of Medicine, Stanford University, Palo Alto, CA, 94304, USA., O'Donnell CJ; Medicine, Cardiology, VA Boston Healthcare System, Boston, MA 02130, USA., Muralidhar S; Office of Research and Development, Department of Veterans Affairs, Washington, DC, 20420, USA., Moser J; Office of Research and Development, Department of Veterans Affairs, Washington, DC, 20420, USA., Casas JP; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA 02130, USA., Bick AG; Department of Medicine, Division of Genetic Medicine, Vanderbilt University, Nashville, TN, 37325, USA., Zhou W; Department of Medicine, Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA.; Stanley Center for Psychiatric Research, Cambridge, MA 02142, USA.; Program in Medical and Population Genetics, Cambridge, MA 02142, USA., Cai T; Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02115, USA., Voight BF; Corporal Michael Crescenz VA Medical Center, Philadelphia, PA 19104, USA.; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania - Perelman School of Medicine, Philadelphia, PA 19104, USA.; Department of Genetics, University of Pennsylvania - Perelman School of Medicine, Philadelphia, PA 19104, USA.; Institute of Translational Medicine and Therapeutics, University of Pennsylvania - Perelman School of Medicine, Philadelphia, PA 19104, USA., Cho K; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.; MVP Boston Coordinating Center, VA Boston Healthcare System, Boston, MA 02111, USA.; Department of Medicine, Division of Aging, Brigham and Women's Hospital, Boston, MA 02115, USA., Gaziano JM; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.; MVP Boston Coordinating Center, VA Boston Healthcare System, Boston, MA 02111, USA.; Department of Medicine, Division of Aging, Brigham and Women's Hospital, Boston, MA 02115, USA., Madduri RK; Data Science and Learning, Argonne National Laboratory, Lemont, IL 60439, USA., Damrauer S; Corporal Michael Crescenz VA Medical Center, Philadelphia, PA 19104, USA.; Department of Genetics, University of Pennsylvania - Perelman School of Medicine, Philadelphia, PA 19104, USA.; Department of Surgery, University of Pennsylvania - Perelman School of Medicine, Philadelphia, PA 19104, USA.; Cardiovascular Institute, University of Pennsylvania - Perelman School of Medicine, Philadelphia, PA 19104, USA., Liao KP; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA 02130, USA.; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.; Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02115, USA.; Medicine, Rheumatology, VA Boston Healthcare System, Boston, MA 02130, USA.; Department of Medicine, Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, Boston, MA 02115, USA.

Publikováno v: Science (New York, N.Y.) [Science] 2024 Jul 19; Vol. 385 (6706), pp. eadj1182. Date of Electronic Publication: 2024 Jul 19.