Zobrazeno 1 - 10
of 165
pro vyhledávání: '"Jozsef Dudas"'
Autor:
Maria do Carmo Greier, Annette Runge, Jozsef Dudas, Roland Hartl, Matthias Santer, Daniel Dejaco, Teresa Bernadette Steinbichler, Julia Federspiel, Christof Seifarth, Marko Konschake, Susanne Sprung, Sieghart Sopper, Avneet Randhawa, Melissa Mayr, Benedikt Gabriel Hofauer, Herbert Riechelmann
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
BackgroundHead and neck squamous cell carcinomas (HNSCC) are highly heterogeneous tumors. In the harsh tumor microenvironment (TME), metabolic reprogramming and mitochondrial dysfunction may lead to immunosuppressive phenotypes. Aerobic glycolysis is
Externí odkaz:
https://doaj.org/article/7e69a60e5eab45c68f556a77a7892fb6
Autor:
Claudia Steinacher, Dietmar Rieder, Jasmin E. Turner, Nita Solanky, Shin-ya Nishio, Shin-ichi Usami, Barbara Hausott, Anneliese Schrott-Fischer, Jozsef Dudas
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 5, p 2907 (2024)
A comprehensive gene expression investigation requires high-quality RNA extraction, in sufficient amounts for real-time quantitative polymerase chain reaction and next-generation sequencing. In this work, we compared different RNA extraction methods
Externí odkaz:
https://doaj.org/article/57c276aa22f7452c83f1313a4add9f3e
Patient-derived head and neck tumor slice cultures: a versatile tool to study oncolytic virus action
Autor:
Annette Runge, Melissa Mayr, Theresa Schwaiger, Susanne Sprung, Paolo Chetta, Timo Gottfried, Jozsef Dudas, Maria C. Greier, Marlies C. Glatz, Johannes Haybaeck, Knut Elbers, Herbert Riechelmann, Patrik Erlmann, Monika Petersson
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Head and neck cancer etiology and architecture is quite diverse and complex, impeding the prediction whether a patient could respond to a particular cancer immunotherapy or combination treatment. A concomitantly arising caveat is obviously t
Externí odkaz:
https://doaj.org/article/9be346a1f80d49898d19c4d438e8b102
Publikováno v:
Biomedicines, Vol 11, Iss 12, p 3301 (2023)
High mortality in head and neck squamous cell carcinoma (HNSCC) is due to recurrence, metastasis, and radiochemotherapy (RCT) resistance. These phenomena are related to the tumor cell subpopulation undergoing partial epithelial to mesenchymal transit
Externí odkaz:
https://doaj.org/article/8027315b3b6941e6a556a81449c6ad9d
Autor:
Maria do Carmo Greier, Annette Runge, Jozsef Dudas, Viktoria Pider, Ira-Ida Skvortsova, Dragana Savic, Herbert Riechelmann
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract Mitochondrial dysfunction promotes cancer aggressiveness, metastasis, and resistance to therapy. Similar traits are associated with epithelial mesenchymal transition (EMT). We questioned whether mitochondrial dysfunction induces EMT in head
Externí odkaz:
https://doaj.org/article/6a3c87fa1ab14b29bfbea69d660c25d5
Autor:
Annette Runge, Sonja Straif, Zoltan Banki, Wegene Borena, Brigitte Muellauer, Juergen Brunner, Timo Gottfried, Joachim Schmutzhard, Jozsef Dudas, Brigitte Risslegger, Avneet Randhawa, Cornelia Lass-Flörl, Dorothee von Laer, Herbert Riechelmann
Publikováno v:
Frontiers in Pediatrics, Vol 11 (2023)
BackgroundThe role of respiratory viruses in chronic otitis media with effusion (COME) in children is not clearly defined. In our study we aimed to investigate the detection of respiratory viruses in middle ear effusions (MEE) as well as the associat
Externí odkaz:
https://doaj.org/article/fdcae559f6b34b71b9632ebdc341893c
Optimizing culturing conditions in patient derived 3D primary slice cultures of head and neck cancer
Autor:
Maria do Carmo Greier, Annette Runge, Jozsef Dudas, Lukas Carpentari, Volker Hans Schartinger, Avneet Randhawa, Melissa Mayr, Monika Petersson, Herbert Riechelmann
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
BackgroundThree-dimensional primary slice cultures (SC) of head and neck squamous cell carcinomas (HNC) are realistic preclinical models. Until now, preserving structure and viability ex vivo for several days has been difficult. The aim of this study
Externí odkaz:
https://doaj.org/article/7bf7e4903f864f2c8ae79a13650af015
Autor:
Claudia Steinacher, Lejo Johnson Chacko, Wei Liu, Helge Rask-Andersen, Werner Bader, Jozsef Dudas, Consolato M. Sergi, Tamilvendhan Dhanaseelan, Nadjeda Moreno, Rudolf Glueckert, Romed Hoermann, Anneliese Schrott-Fischer
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
BackgroundHuman inner ear contains macrophages whose functional role in early development is yet unclear. Recent studies describe inner ear macrophages act as effector cells of the innate immune system and are often activated following acoustic traum
Externí odkaz:
https://doaj.org/article/cc09affbb34c4a018b6d447b3052b1c3
Publikováno v:
Biomedicines, Vol 10, Iss 10, p 2482 (2022)
This study aims to investigate the role of partial epithelial to mesenchymal transition (pEMT)-related proteins in modulating Cisplatin resistance in head and neck squamous cell carcinoma (HNSCC). SCC-25 cells were pre-treated with TGF-beta1 followed
Externí odkaz:
https://doaj.org/article/f71f328c5ae64684b0c1667f07a05df7
Autor:
Barbara Kofler, Angela Romani, Christian Pritz, Teresa Bernadette Steinbichler, Volker Hans Schartinger, Herbert Riechelmann, Jozsef Dudas
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 4, p 1107 (2018)
Photodynamic therapy (PDT) is suggested to have an impact on the treatment of early stage head and neck cancers (HNSCC). We investigated the effect of PDT with methylene blue (MB) and a diode laser (660 nm) as the laser source on HNSCC cell lines as
Externí odkaz:
https://doaj.org/article/b65636e64fee4bb39003f0e86486fd12