The Mincle-Activating Adjuvant TDB Induces MyD88-Dependent Th1 and Th17 Responses through IL-1R Signaling

Autor: Desel, Christiane, Werninghaus, Kerstin, Ritter, Manuel, Jozefowski, Katrin, Wenzel, Jens, Russkamp, Norman, Schleicher, Ulrike, Christensen, Dennis, Wirtz, Stefan, Kirschning, Carsten Jürgen, Agger, Else Marie, Prazeres da Costa, Clarissa, Lang, Roland

Publikováno v: PLoS ONE
PLoS ONE, Vol 8, Iss 1, p e53531 (2013)
PLoS ONE; Vol 8

Successful vaccination against intracellular pathogens requires the generation of cellular immune responses. Trehalose-6,6-dibehenate (TDB), the synthetic analog of the mycobacterial cord factor trehalose-6,6-dimycolate (TDM), is a potent adjuvant in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::40f3ab85ccd0a8c34da7a01e232bfa45
http://europepmc.org/articles/PMC3538599

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Increased inflammation and lethality of Dusp1^−/− mice in polymicrobial peritonitis models.

Autor: Hammer, Michael, Echtenachter, Bernd, Weighardt, Heike, Jozefowski, Katrin, Rose-John, Stefan, Männel, Daniela N., Holzmann, Bernhard, Lang, Roland

Publikováno v: Immunology; Nov2010, Vol. 131 Issue 3, p395-404, 10p, 5 Graphs

Stat6-Dependent Inhibition of Mincle Expression in Mouse and Human Antigen-Presenting Cells by the Th2 Cytokine IL-4.

Autor: Hupfer T; Institute of Clinical Microbiology, Immunology and Hygiene, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg , Erlangen , Germany., Schick J; Institute of Clinical Microbiology, Immunology and Hygiene, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg , Erlangen , Germany., Jozefowski K; Institute of Clinical Microbiology, Immunology and Hygiene, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg , Erlangen , Germany., Voehringer D; Department of Infection Biology, Universitätsklinikum Erlangen, Friedrich-Alexander Universität Erlangen-Nürnberg , Erlangen , Germany., Ostrop J; Institute of Clinical Microbiology, Immunology and Hygiene, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany; Department of Cancer Research and Molecular Medicine, Centre of Molecular Inflammation Research, Norwegian University of Science and Technology (NTNU), Trondheim, Norway., Lang R; Institute of Clinical Microbiology, Immunology and Hygiene, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg , Erlangen , Germany.

Publikováno v: Frontiers in immunology [Front Immunol] 2016 Oct 14; Vol. 7, pp. 423. Date of Electronic Publication: 2016 Oct 14 (Print Publication: 2016).