Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Jozef Spychala"'
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0123773 (2015)
In this report we describe a novel graphically oriented method for pathway modeling and a software package that allows for both modeling and visualization of biological networks in a user-friendly format. The Visinets mathematical approach is based o
Externí odkaz:
https://doaj.org/article/aed482fc4fcc4c83aeb3037f9175554b
Publikováno v:
Nucleosides, Nucleotides and Nucleic Acids. 25:1119-1123
Upregulated expression of eN has been found in the highly invasive human melanoma cell lines but neither in melanocytes nor in primary tumor cells. Membrane proteins associated with cell adhesion and metastasis: alpha5-, beta1-, beta3-integrins, and
Autor:
David R. Archer, Jozef Spychala, Takita Felder Sumter, Bagirath Gangadharan, Erin L. Morrey, H. Trent Spencer, Tasha Gray
Publikováno v:
Cancer Chemotherapy and Pharmacology. 58:117-128
Purpose: Retroviral transfer of cDNA sequences that confer drug resistance can be used to protect against chemotherapy-induced hematopoietic toxicity and for the selective expansion of gene-modified cells. To successfully expand genetically engineere
Autor:
Angus C. Nairn, Bogachan Sahin, Jozef Spychala, Steven E. Ealick, James A. Bibb, Allen A. Fienberg, Robert W. Greene, Janice W. Kansy
Publikováno v:
European Journal of Biochemistry. 271:3547-3555
The regulation of adenosine kinase (AK) activity has the potential to control intracellular and interstitial adenosine (Ado) concentrations. In an effort to study the role of AK in Ado homeostasis in the central nervous system, two isoforms of the en
Autor:
Jan Kitajewski, Jozef Spychala
Publikováno v:
Experimental Cell Research. 296:99-108
Solid tumors, which routinely experience necrosis and ischemia, release and degrade adenine nucleotides. This process may lead, depending on the expression of enzymes that regulate adenosine, to the generation of extracellular adenosine. Since genes
Autor:
Jozef Spychala, Vera Bianchi
Publikováno v:
Journal of Biological Chemistry. 278:46195-46198
Publikováno v:
Journal of Biological Chemistry. 276:10498-10504
Nucleoside analogs are important in the treatment of hematologic malignancies, solid tumors, and viral infections. Their metabolism to the triphosphate form is central to their chemotherapeutic efficacy. Although the nucleoside kinases responsible fo
Publikováno v:
Journal of Biological Chemistry. 274:22705-22712
We have isolated the 5' region of the ecto-5'-nucleotidase (low K(m) 5'-NT) gene and established that a 969-base pair (bp) fragment confers cell-specific expression of a CAT reporter gene that correlates with the expression of endogenous ecto-5'-NT m
Publikováno v:
Journal of Biological Chemistry. 272:4458-4466
Catalysis of guanine nucleotide formation from IMP in the de novo purine synthetic pathway is carried out by two isoforms of the enzyme inosine monophosphate dehydrogenase (IMPDH) that are catalytically indistinguishable but are encoded by separate g
Publikováno v:
Advances in Enzyme Regulation. 36:75-84
Inosine 5′-monophosphate dehydrogenase (IMPDH) is an essential ratelimiting enzyme in the de novo guanine nucleotide synthetic pathway that catalyzes the conversion of IMP to XMP. Enzyme activity is accounted for by the expression of two distinct b