Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Jozef Hritz"'
Autor:
Neha Basheer, Luc Buee, Jean-Pierre Brion, Tomas Smolek, Muhammad Khalid Muhammadi, Jozef Hritz, Tomas Hromadka, Ilse Dewachter, Susanne Wegmann, Isabelle Landrieu, Petr Novak, Amritpal Mudher, Norbert Zilka
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-31 (2024)
Abstract The transcellular propagation of the aberrantly modified protein tau along the functional brain network is a key hallmark of Alzheimer's disease and related tauopathies. Inoculation-based tau propagation models can recapitulate the stereotyp
Externí odkaz:
https://doaj.org/article/0547cc546b564dafa9cf1056d3b05ad1
Autor:
Aneta Kozeleková, Alexandra Náplavová, Tomáš Brom, Norbert Gašparik, Jan Šimek, Josef Houser, Jozef Hritz
Publikováno v:
Frontiers in Chemistry, Vol 10 (2022)
Protein phosphorylation is a critical mechanism that biology uses to govern cellular processes. To study the impact of phosphorylation on protein properties, a fully and specifically phosphorylated sample is required although not always achievable. C
Externí odkaz:
https://doaj.org/article/3bfdb89ec8e14cf4b0ea960a94f87395
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Tauopathies, including Alzheimer’s disease (AD), are the most troublesome of all age-related chronic conditions, as there are no well-established disease-modifying therapies for their prevention and treatment. Spatio-temporal distribution of tau pr
Externí odkaz:
https://doaj.org/article/217c956f629f478a813ac5043d5e8955
Autor:
Vojtech Kuban, Pavel Macek, Jozef Hritz, Katerina Nechvatalova, Katerina Nedbalcova, Martin Faldyna, Peter Sebo, Lukas Zidek, Ladislav Bumba
Publikováno v:
mBio, Vol 11, Iss 2 (2020)
ABSTRACT The posttranslational Ca2+-dependent “clip-and-link” activity of large repeat-in-toxin (RTX) proteins starts by Ca2+-dependent structural rearrangement of a highly conserved self-processing module (SPM). Subsequently, an internal asparta
Externí odkaz:
https://doaj.org/article/fdc4a6e79d8040c09e2fbb26185124d6
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0180633 (2017)
The 14-3-3 protein family performs regulatory functions in eukaryotic organisms by binding to a large number of phosphorylated protein partners. Whilst the binding mode of the phosphopeptides within the primary 14-3-3 binding site is well established
Externí odkaz:
https://doaj.org/article/b8327bb3664e4ca98f9e302902ce31a0
Autor:
Kateřina Melková, Vojtěch Zapletal, Subhash Narasimhan, Séverine Jansen, Jozef Hritz, Rostislav Škrabana, Markus Zweckstetter, Malene Ringkjøbing Jensen, Martin Blackledge, Lukáš Žídek
Publikováno v:
Biomolecules, Vol 9, Iss 3, p 105 (2019)
The stability and dynamics of cytoskeleton in brain nerve cells are regulated by microtubule associated proteins (MAPs), tau and MAP2. Both proteins are intrinsically disordered and involved in multiple molecular interactions important for normal phy
Externí odkaz:
https://doaj.org/article/d155b53d6f6b4cfaa9b93d76dd506228
Publikováno v:
International Journal of Photoenergy, Vol 4, Iss 2, Pp 45-50 (2002)
Molecular modeling has been employed to study the interaction of hypericin (Hyp) with human serum albumin (HSA). The structural model for Hyp/HSA complex is presented. Our results indicate that Hyp is bound in II A subdomain of HSA close to the trypt
Externí odkaz:
https://doaj.org/article/dbfb8860fa3046489aa4ed8b7f0d9655
Autor:
Christina L Gardner, Jozef Hritz, Chengqun Sun, Dana L Vanlandingham, Timothy Y Song, Elodie Ghedin, Stephen Higgs, William B Klimstra, Kate D Ryman
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 8, Iss 2, p e2719 (2014)
Mosquito-borne chikungunya virus (CHIKV) is a positive-sense, single-stranded RNA virus from the genus Alphavirus, family Togaviridae, which causes fever, rash and severe persistent polyarthralgia in humans. Since there are currently no FDA licensed
Externí odkaz:
https://doaj.org/article/bd01950fdf944de7be1a383c6be4f8b4
Autor:
Alessia Lasorsa, Krishnendu Bera, Idir Malki, Elian Dupré, François-Xavier Cantrelle, Hamida Merzougui, Davy Sinnaeve, Xavier Hanoulle, Jozef Hritz, Isabelle Landrieu
Publikováno v:
Biochemistry
Biochemistry, 2023, 62 (11), pp.1631-1642. ⟨10.1021/acs.biochem.2c00717⟩
Biochemistry, 2023, 62 (11), pp.1631-1642. ⟨10.1021/acs.biochem.2c00717⟩
International audience; An increase in phosphorylation of the Tau protein is associated with Alzheimer's disease (AD) progression through unclear molecular mechanisms. In general, phosphorylation modifies the interaction of intrinsically disordered p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0eb065a46bb40bcd3eed5979b7677031
https://doi.org/10.1021/acs.biochem.2c00717
https://doi.org/10.1021/acs.biochem.2c00717
Autor:
Kristine Kitoka, Alons Lends, Gytis Kučinskas, Anna Lina Bula, Lukas Krasauskas, Vytautas Smirnovas, Rostislav Skrabana, Jozef Hritz, Kristaps Jaudzems
The microtubule associated protein tau forms disease-specific filamentous aggregates in several different neurodegenerative diseases. In order to understand how tau undergoes misfolding into a specific filament type and to be able to control this pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63ad81edd126a7662adff8253bf05eeb
https://doi.org/10.1101/2023.02.01.526268
https://doi.org/10.1101/2023.02.01.526268
