Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Jozef Al-Gousous"'
Autor:
Mauricio A. García, Felipe Varum, Jozef Al-Gousous, Michael Hofmann, Susanne Page, Peter Langguth
Publikováno v:
Pharmaceutics, Vol 14, Iss 2, p 291 (2022)
Several locally acting colon-targeted products to treat colonic diseases have been recently developed and marketed, taking advantage of gastrointestinal physiology to target delivery. Main mechanisms involve pH-dependent, time-controlled and/or enzym
Externí odkaz:
https://doaj.org/article/4f8499e8a1104f68b689f5d4cecb8533
Publikováno v:
Pharmaceuticals, Vol 14, Iss 12, p 1327 (2021)
Hydrogen, as a medical gas, is a promising emerging treatment for many diseases related to inflammation and oxidative stress. Molecular hydrogen can be generated through hydrogen ion reduction by a metal, and magnesium-containing effervescent tablets
Externí odkaz:
https://doaj.org/article/1bb8ef83191e41bd810072b316132bc7
Autor:
Johannes Andreas Blechar, Jozef Al-Gousous, Christoph Wilhelmy, Annika Marielina Postina, Marcus Getto, Peter Langguth
Publikováno v:
Pharmaceutics, Vol 12, Iss 12, p 1197 (2020)
The in vivo dissolution of enteric-coated (EC) products is often overestimated by compendial in vitro dissolution experiments. It is of great interest to mimic the in vivo conditions as closely as possible in vitro in order to predict the in vivo beh
Externí odkaz:
https://doaj.org/article/42c4b85c7bd54cd0a56542689877853e
Autor:
Christian D. Siewert, Heinrich Haas, Vera Cornet, Sara S. Nogueira, Thomas Nawroth, Lukas Uebbing, Antje Ziller, Jozef Al-Gousous, Aurel Radulescu, Martin A. Schroer, Clement E. Blanchet, Dmitri I. Svergun, Markus P. Radsak, Ugur Sahin, Peter Langguth
Publikováno v:
Cells, Vol 9, Iss 9, p 2034 (2020)
Hybrid nanoparticles from lipidic and polymeric components were assembled to serve as vehicles for the transfection of messenger RNA (mRNA) using different portions of the cationic lipid DOTAP (1,2-Dioleoyl-3-trimethylammonium-propane) and the cation
Externí odkaz:
https://doaj.org/article/ccd7af2a8e2e49719ca289339c9736b3
Publikováno v:
Pharmaceutics, Vol 12, Iss 8, p 696 (2020)
A comparative study on different enteric-coated hard capsules was performed. The influence of different formulation factors like choice of enteric polymer, triethyl citrate (TEC) concentration (plasticizer), talc concentrations (anti-tacking agent),
Externí odkaz:
https://doaj.org/article/33a733cc3d5a4c8d8e30c5d5b7a323ce
Autor:
Daniela Amaral Silva, Jozef Al-Gousous, Neal M. Davies, Nadia Bou Chacra, Gregory K. Webster, Elke Lipka, Gordon L. Amidon, Raimar Löbenberg
Publikováno v:
Pharmaceutics, Vol 12, Iss 5, p 420 (2020)
Dissolution testing is a major tool used to assess a drug product’s performance and as a quality control test for solid oral dosage forms. However, compendial equipment and methods may lack discriminatory power and the ability to simulate aspects o
Externí odkaz:
https://doaj.org/article/95601e7b79904e82aa44db104dba1221
Publikováno v:
Pharmaceutics, Vol 12, Iss 2, p 123 (2020)
In this study, the potential for correlation between disintegration and dissolution performance of enteric-coated (EC) dosage forms was investigated. Different enteric hard shell capsule formulations containing caffeine as model drug were tested for
Externí odkaz:
https://doaj.org/article/b2ff88e05fe240f3854eb5e8a7958d72
Autor:
Marival Bermejo, Gislaine Kuminek, Jozef Al-Gousous, Alejandro Ruiz-Picazo, Yasuhiro Tsume, Alfredo Garcia-Arieta, Isabel González-Alvarez, Bart Hens, Gregory E. Amidon, Nair Rodriguez-Hornedo, Gordon L. Amidon, Deanna Mudie
Publikováno v:
Pharmaceutics, Vol 11, Iss 3, p 122 (2019)
The present work aimed to explain the differences in oral performance in fasted humans who were categorized into groups based on the three different drug product formulations of dexketoprofen trometamol (DKT) salt—Using a combination of in vitro te
Externí odkaz:
https://doaj.org/article/8fa34fe3d1fe4e7e93dffe3265f92e6e
Autor:
Jozef Al-Gousous, Gislaine Kuminek, David C. Sperry, Gordon L. Amidon, Nicholas M Waltz, Dale Greenwood, Gregory E. Amidon, Niloufar Salehi, Robert M. Ziff
Publikováno v:
Molecular Pharmaceutics. 18:3326-3341
Orally dosed drugs must dissolve in the gastrointestinal (GI) tract before being absorbed through the epithelial cell membrane. In vivo drug dissolution depends on the GI tract's physiological conditions such as pH, residence time, luminal buffers, i
Autor:
Mauricio A. García, Gönül Hensler, Jozef Al-Gousous, Jonas Pielenhofer, Manfred Wagner, Hans Lennernäs, Peter Langguth
Publikováno v:
Drug Metabolism and Pharmacokinetics. 49:100491