Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Jozafina Milicaj"'
Autor:
Jozafina Milicaj, Bakar A. Hassan, Joy M. Cote, Carlos A. Ramirez-Mondragon, Nadiya Jaunbocus, Angelika Rafalowski, Kaelan R. Patel, Colleen D. Castro, Ramaiah Muthyala, Yuk Y. Sham, Erika A. Taylor
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)
Abstract A clinically relevant inhibitor for Heptosyltransferase I (HepI) has been sought after for many years because of its critical role in the biosynthesis of lipopolysaccharides on bacterial cell surfaces. While many labs have discovered or desi
Externí odkaz:
https://doaj.org/article/bcc4b0c42cce4877be0993ff4f99cb78
Publikováno v:
Applied Sciences, Vol 11, Iss 18, p 8314 (2021)
The enzymes involved in lipopolysaccharide (LPS) biosynthesis, including Heptosyltransferase I (HepI), are critical for maintaining the integrity of the bacterial cell wall, and therefore these LPS biosynthetic enzymes are validated targets for drug
Externí odkaz:
https://doaj.org/article/94665a32d82e41588a5f921d7ee1dae1
Autor:
Carlos A. Ramirez-Mondragon, Megin E. Nguyen, Jozafina Milicaj, Bakar A. Hassan, Frank J. Tucci, Ramaiah Muthyala, Jiali Gao, Erika A. Taylor, Yuk Y. Sham
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 9, p 4619 (2021)
It has long been understood that some proteins undergo conformational transitions en route to the Michaelis Complex to allow chemistry. Examination of crystal structures of glycosyltransferase enzymes in the GT-B structural class reveals that the pre
Externí odkaz:
https://doaj.org/article/1686a2140c5044349958c396a17e8907
Autor:
Bakar A. Hassan, Zhiqi A. Liu, Jozafina Milicaj, Mia S. Kim, Meka Tyson, Yuk Y. Sham, Erika A. Taylor
Publikováno v:
Biochemistry. 61:1572-1584
Autor:
Jozafina Milicaj, Vasudeva R. Dodda, Kaelan R. Patel, Ingrid Rodriguez Aragon, Timothy O’Connell, Ramaiah Muthyala, Erika A. Taylor, Yuk Y. Sham
Publikováno v:
Journal of Chemical Education. 99:1428-1434
Autor:
Bakar A. Hassan, Jozafina Milicaj, Carlos Andres Ramirez-Mondragon, Yuk Yin Sham, Erika A. Taylor
Publikováno v:
J Chem Inf Model
Understanding the dynamical motions and ligand recognition motifs of heptosyltransferase I (HepI) can be critical to discerning the behavior of other glycosyltransferase (GT) enzymes. Prior studies in our lab have demonstrated that GTs in the GT-B st
Autor:
Bakar A. Hassan, Zhiqi A. Liu, Jozafina Milicaj, Mia S. Kim, Meka Tyson, Yuk Y. Sham, Erika A. Taylor
Glycosyltransferases (GTs) are enzymes that are uniquely adapted to promote the formation of a glycosidic bond between a sugar molecule and a wide variety of substrates. Heptosyltransferase II (HepII) is a GT involved in the lipopolysaccharide (LPS)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dfa6d9fcd0e61f69ea21cbd7bb87d062
https://doi.org/10.1101/2022.06.13.495986
https://doi.org/10.1101/2022.06.13.495986
Autor:
Bakar A. Hassan, Erika A. Taylor, Kaelan R Patel, Colleen D. Castro, Joy M. Cote, Yuk Y. Sham, Jozafina Milicaj, Angelika Rafalowski, Ramaiah Muthyala, Carlos A. Ramirez-Mondragon, Nadiya A. Jaunbocus
A clinically relevant inhibitor for Heptosyltransferase I (HepI) has been sought after for many years and while many have designed novel small-molecule inhibitors, these compounds lack the bioavailability and potency necessary for therapeutic use. Ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ede2e5e7bf25c056769cacb0d177914
https://doi.org/10.1101/2021.10.03.462930
https://doi.org/10.1101/2021.10.03.462930
Autor:
Colleen D. Castro, Huixiao Fu, Tianlei Li, Marine Lacritick, Weidong Pan, Abdellatif Tikad, Erika A. Taylor, Stéphane P. Vincent, Jozafina Milicaj
The multistep synthesis of a novel ADP-7-azido-7-deoxy-l-glycero-β-d-manno-heptopyranoside 2a and several analogues as heptosyltransferase ligands is described. The synthesis of the key intermediate heptoside-1-β-phosphate 3a involved a β-stereose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5b93e024836183904cb4ad4e7a188c0
https://researchportal.unamur.be/en/publications/bda79e49-8ce3-48b1-a8f3-f3a3fcd61827
https://researchportal.unamur.be/en/publications/bda79e49-8ce3-48b1-a8f3-f3a3fcd61827