Association between leukocyte telomere length and the risk of pancreatic cancer: Findings from a prospective study.

Autor: Hung N Luu, Joyce Y Huang, Renwei Wang, Jennifer Adams-Haduch, Aizhen Jin, Woon-Puay Koh, Jian-Min Yuan

Publikováno v: PLoS ONE, Vol 14, Iss 8, p e0221697 (2019)

IntroductionTelomeres and telomerase play important role in maintaining chromosome integrity and genomic stability. Recent epidemiologic data showed inconsistent findings which suggested that both short and long leukocyte telomeres could be associate

Externí odkaz: https://doaj.org/article/91691cdab30b4358a672ec707d0915d9

Data from Dietary Intake of One-Carbon Metabolism–Related Nutrients and Pancreatic Cancer Risk: The Singapore Chinese Health Study

Autor: Jian-Min Yuan, Woon-Puay Koh, Aizhen Jin, Renwei Wang, Lesley M. Butler, Joyce Y. Huang

Background: Nutrients involved in one-carbon metabolism are hypothesized to protect against pancreatic cancer development.Methods: The Singapore Chinese Health Study database was used to prospectively examine the association between intake of one-car

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34f6d6cd049073d812b4def4fc5d3a34
https://doi.org/10.1158/1055-9965.c.6516391

A prospective evaluation of serum methionine‐related metabolites in relation to pancreatic cancer risk in two prospective cohort studies

Autor: Arve Ulvik, Per Magne Ueland, Yu-Ting Tan, Hung N. Luu, Woon-Puay Koh, Renwei Wang, Jian-Min Yuan, Aizhen Jin, Joyce Y. Huang, Yu-Tang Gao, Øivind Midttun, Lesley M. Butler

Publikováno v: International Journal of Cancer. 147:1917-1927

Deficiencies in methyl donor status may render DNA methylation changes and DNA damage, leading to carcinogenesis. Epidemiological studies reported that higher dietary intake of choline is associated with lower risk of pancreatic cancer, but no study

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70675a08fde4fe02fa8365e39f0a03f8
https://doi.org/10.1002/ijc.32994

Leukocyte telomere length in relation to risk of lung adenocarcinoma incidence: Findings from the Singapore Chinese Health Study

Autor: Woon-Puay Koh, Patricia L. Opresko, Anne B. Newman, Jennifer M. Adams-Haduch, Renwei Wang, Kenneth B. Beckman, Joyce Y. Huang, Jian-Min Yuan, Aizhen Jin, Michael Fenech, Yun-Ling Zheng, Caroline Bull

Publikováno v: International Journal of Cancer. 142:2234-2243

Telomeres are crucial in the maintenance of chromosome integrity and genomic stability. Critically short telomeres can trigger programed cell death while cells with longer telomeres may have increased likelihood of replicative errors, resulting in ge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8d5f91a4cfe955dd94a41061d76bc6f0
https://doi.org/10.1002/ijc.31251

Circulating markers of cellular immune activation in prediagnostic blood sample and lung cancer risk in the Lung Cancer Cohort Consortium (LC3)

Autor: Woon-Puay Koh, Mattias Johansson, Allison M. Hodge, Jian-Min Yuan, Renwei Wang, Jonas Manjer, Graham G. Giles, Anouar Fanidi, I-Min Lee, Xiao-Ou Shu, Tricia L Larose, Gianluca Severi, Christopher A. Haiman, L R Wilkens, Joyce Y. Huang, Karine Alcala, Kala Visvanathan, Loic Le Marchand, Victoria L. Stevens, Qiuyin Cai, Jiali Han, Alan A. Arslan, Caroline L Relton, Howard D. Sesso, Regina G. Ziegler, Yong-Bing Xiang, Ross L. Prentice, J. Michael Gaziano, Kjell Grankvist, Jie Wu, Meir J. Stampfer, Paul Brennan, Qing Lan, Neal D. Freedman, Mikael Johansson, Yu-Tang Gao, Demetrius Albanes, Anne Zeleniuch-Jacquotte, Stephanie J. Weinstein, Arnulf Langhammer, Wei Zheng, Xuehong Zhang, Neil E. Caporaso, Per Magne Ueland, Hung N. Luu, Mark P. Purdue, William J. Blot, Honglan Li, Arve Ulvi, Julie E. Buring, Øivind Midttun, Kristian Hveem, Mary Pettinger, Cynthia A. Thomson

Publikováno v: Huang, J Y, Larose, T L, Luu, H N, Wang, R, Fanidi, A, Alcala, K, Stevens, V L, Weinstein, S J, Albanes, D, Caporaso, N E, Purdue, M P, Ziegler, R G, Freedman, N D, Lan, Q, Prentice, R L, Pettinger, M, Thomson, C A, Cai, Q, Wu, J, Blot, W J, Shu, X-O, Zheng, W, Arslan, A A, Zeleniuch-Jacquotte, A, Le Marchand, L, Wilkens, L R, Haiman, C A, Zhang, X, Stampfer, M J, Han, J, Giles, G G, Hodge, A M, Severi, G, Johansson, M, Grankvist, K, Langhammer, A, Hveem, K, Xiang, Y-B, Li, H-L, Gao, Y-T, Visvanathan, K, Ueland, P M, Midttun, Ø, Ulvi, A, Buring, J E, Lee, I-M, Sesso, H D, Gaziano, J M, Manjer, J, Relton, C, Koh, W-P, Brennan, P, Johansson, M & Yuan, J-M 2019, ' Circulating markers of cellular immune activation in prediagnostic blood sample and lung cancer risk in the Lung Cancer Cohort Consortium (LC3) ', International Journal of Cancer . https://doi.org/10.1002/ijc.32555

Cell-mediated immune suppression may play an important role in lung carcinogenesis. We investigated the associations for circulating levels of tryptophan, kynurenine, kynurenine:tryptophan ratio (KTR), quinolinic acid (QA) and neopterin as markers of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d373254dfd238678a765721e6958b32d
https://research-information.bris.ac.uk/en/publications/55db2633-c4b7-4918-ab6b-cbeb03d46b16