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Akademický článek

Citrulline protects mice from experimental cerebral malaria by ameliorating hypoargininemia, urea cycle changes and vascular leak.

Autor: Irene Gramaglia, Joyce Velez, Yu-Sun Chang, Wilson Caparros-Wanderley, Valery Combes, Georges Grau, Monique F Stins, Henri C van der Heyde

Publikováno v: PLoS ONE, Vol 14, Iss 3, p e0213428 (2019)

Clinical and model studies indicate that low nitric oxide (NO) bioavailability due in part to profound hypoargininemia contributes to cerebral malaria (CM) pathogenesis. Protection against CM pathogenesis may be achieved by altering the diet before i

Externí odkaz: https://doaj.org/article/cfd0cdb2b1e14cb18c40271e19758a88

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Platelets activate a pathogenic response to blood-stage Plasmodium infection but not a protective immune response

Autor: Valery Combes, Joyce Velez, Melanie Wree, Irene Gramaglia, Henri C. van der Heyde, Georges E. Grau

Publikováno v: Blood. 129:1669-1679

© 2017 by The American Society of Hematology. Clinical studies indicate that thrombocytopenia correlates with the development of severe falciparum malaria, suggesting that platelets either contribute to control of parasite replication, possibly as i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73fb54a2affd56e5624c91dc1351972f
https://doi.org/10.1182/blood-2016-08-733519

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Release of Soluble Insulin Receptor From Neurons by Cerebrospinal Fluid From Patients With Neurocognitive Dysfunction and HIV Infection

Autor: Joyce Velez, Valerie Wojna, Lisa J. Henderson, Raissa Menéndez-Delmestre, Javier E. Sierra-Pagan, Andrea Delgado-Nieves, Yamil Gerena, Jarold Méndez-Álvarez, Avindra Nath, Richard L. Skolasky

Publikováno v: Frontiers in Neurology, Vol 10 (2019)
Frontiers in Neurology

Previously, we found that high levels of soluble insulin receptor (sIR) in the cerebrospinal fluid (CSF) of an HIV-infected women cohort were associated with the presence and severity of HIV-associated neurocognitive disorders (HAND). In this study w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a91d583fccecc4a6b5a4394c75a7d125
https://www.frontiersin.org/article/10.3389/fneur.2019.00285/full

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Platelets activate a pathogenic response to blood-stage

Autor: Irene, Gramaglia, Joyce, Velez, Valery, Combes, Georges E R, Grau, Melanie, Wree, Henri C, van der Heyde

Publikováno v: Blood. 129(12)

Clinical studies indicate that thrombocytopenia correlates with the development of severe falciparum malaria, suggesting that platelets either contribute to control of parasite replication, possibly as innate parasite killer cells or function in elic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::31f1449117a6efbafe9f4c7865cf1d2a
https://pubmed.ncbi.nlm.nih.gov/28336729

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4R-cembranoid protects against diisopropylfluorophosphate-mediated neurodegeneration

Autor: Wilmarie Torres-Rivera, Rebeca Reyes Salaman, Jae Eun Lee, Joyce Velez-Roman, Vesna A. Eterovic, Annabell C. Segarra, Myrna Andino, Antonio H. Martins, P.A. Ferchmin, Marimée Carrasco, Brenda L. Cuadrado, Janaina Maria Alves

Many organophosphorous esters synthesized for applications in industry, agriculture, or warfare irreversibly inhibit acetylcholinesterase, and acute poisoning with these compounds causes life-threatening cholinergic overstimulation. Following classic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a07b81eb676b3b4dc89cdd218f413bf4
https://europepmc.org/articles/PMC4176603/