Zobrazeno 1 - 10
of 110
pro vyhledávání: '"Joyce Tombran, Tink"'
Autor:
Changjie Ren, Peiran Zhou, Mingliang Zhang, Zihao Yu, Xiaomin Zhang, Joyce Tombran-Tink, Colin J. Barnstable, Xiaorong Li
Publikováno v:
International Journal of Molecular Sciences
Volume 24
Issue 4
Pages: 3565
Volume 24
Issue 4
Pages: 3565
Caffeic acid phenylethyl ester (CAPE) is an antioxidative agent originally derived from propolis. Oxidative stress is a significant pathogenic factor in most retinal diseases. Our previous study revealed that CAPE suppresses mitochondrial ROS product
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b2769691388879936f48cdc9b91a6cf
Autor:
Manhong Xu, Yilin Jiang, Lin Su, Xin Chen, Xianfeng Shao, Vicki Ea, Zhenying Shang, Xiaomin Zhang, Colin J. Barnstable, Xiaorong Li, Joyce Tombran-Tink
Publikováno v:
Journal of Proteome Research. 21:101-117
The purpose of this study was to identify proteins that regulate vascular remodeling in an ROP mouse model. Pups were subjected to fluctuating oxygen levels and retinas sampled during vessel regression (PN12) or neovascularization (PN17) for comparat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e60bff80a9f04db17d029e69c13cdfd3
https://doi.org/10.1021/acs.jproteome.1c00547
https://doi.org/10.1021/acs.jproteome.1c00547
Publikováno v:
Current Eye Research. 46:302-308
To investigate the antioxidative effect and mechanism of pigment epithelium-derived factor (PEDF) on the ocular surface damage in diabetic mice.C57BL/6 mice were injected intraperitoneally with streptozocin to generate diabetic models and then 50 nM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::789c2422de41d69cafa262fac0072334
https://doi.org/10.1080/02713683.2020.1805770
https://doi.org/10.1080/02713683.2020.1805770
Autor:
Joyce Tombran-Tink
Publikováno v:
Ophthalmic Drug Delivery Systems ISBN: 9781003113423
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc43b701b0051c79bee10cb67b89a510
https://doi.org/10.4324/9781003113423-23
https://doi.org/10.4324/9781003113423-23
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0133777 (2015)
Our recent publication showed that a small bioactive pigment epithelium derived factor (PEDF) peptide (P78-PEDF) prevents the development of diabetic nephropathy (DN). However, its effects on the progression of established DN were not clear. Therefor
Externí odkaz:
https://doaj.org/article/ad11a2b3174745c988c95fa11d2d0d3f
Publikováno v:
Experimental Eye Research. 222:109171
Retinal diseases are often accompanied by inflammation, vascular abnormalities, and neurodegeneration that decrease vision. Treatment with exogenous PEDF is widely shown to alleviate these conditions leading us to hypothesize that loss of function of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8be38df9d1fdaec480b47ecc9cbed0c8
https://doi.org/10.1016/j.exer.2022.109171
https://doi.org/10.1016/j.exer.2022.109171
Autor:
Joyce Tombran-Tink, Xiaorong Li, Mingliang Zhang, Songyang Yang, Xiaomin Zhang, Colin J. Barnstable
Publikováno v:
Experimental eye research. 213
Pigment epithelium derived factor (PEDF), an endogenous inhibitor of angiogenesis, targets the growth of aberrant blood vessels in many tissues, including the eye. In this study we show that PEDF prevented early mitogenic signals of vascular endothel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50ac754c12c0e74ecd8d25d4850fbabe
https://pubmed.ncbi.nlm.nih.gov/34742690
https://pubmed.ncbi.nlm.nih.gov/34742690
Autor:
Dejia Wen, Lanlan Hu, Xiaorong Li, Changjie Ren, Mingliang Zhang, Shuang Chen, Liming Wang, Joyce Tombran-Tink, Zihao Yu, Colin J. Barnstable, Xiaomin Zhang, Zhihui Zhang
Publikováno v:
Neurochemistry international. 151
Oxidative stress due to mitochondrial produced reactive oxygen species is a major cause of damage seen in many retinal degenerative diseases. Caffeic acid phenylethyl ester （CAPE） is protective agent in multiple tissues and is reported to have an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0097db31b5145e8a5226ac1ae9755392
https://pubmed.ncbi.nlm.nih.gov/34710532
https://pubmed.ncbi.nlm.nih.gov/34710532
Autor:
Ana Rubin Panvini, Anzor Gvritishvili, Hannah Galvan, Sonali Nashine, Shari R. Atilano, M. Cristina Kenney, Joyce Tombran-Tink
Publikováno v:
Exp Eye Res
Mitochondrial dysfunction is associated with several retinal degenerative diseases including Age-related Macular Degeneration (AMD). Human mitochondrial DNA (mtDNA) haplogroups are inherited from a common ancestral clan and are defined by specific se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fad46945c7055c7d82f010683be4411c
https://doi.org/10.1016/j.exer.2022.109013
https://doi.org/10.1016/j.exer.2022.109013
Publikováno v:
International Journal of Molecular Sciences. 23:5672
Most of the major retinal degenerative diseases are associated with significant levels of oxidative stress. One of the major sources contributing to the overall level of stress is the reactive oxygen species (ROS) generated by mitochondria. The drivi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b550ed0c86b8a3838d08fb9fe446182
https://doi.org/10.3390/ijms23105672
https://doi.org/10.3390/ijms23105672