Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Joyce T. O'Connell"'
Autor:
Chao Dai, Jonathan P. Rennhack, Taylor E. Arnoff, Maneesha Thaker, Scott T. Younger, John G. Doench, August Yue Huang, Annan Yang, Andrew J. Aguirre, Belinda Wang, Evan Mun, Joyce T. O’Connell, Ying Huang, Katherine Labella, Jessica A. Talamas, Ji Li, Nina Ilic, Justin Hwang, Andrew L. Hong, Andrew O. Giacomelli, Ole Gjoerup, David E. Root, William C. Hahn
Publikováno v:
Cell Reports, Vol 36, Iss 4, Pp 109443- (2021)
Summary: Metastasis is a complex and poorly understood process. In pancreatic cancer, loss of the transforming growth factor (TGF)-β/BMP effector SMAD4 is correlated with changes in altered histopathological transitions, metastatic disease, and poor
Externí odkaz:
https://doaj.org/article/576815dfcfd2415692f51077629b4730
Autor:
Lisa M. Becker, Joyce T. O’Connell, Annie P. Vo, Margo P. Cain, Desiree Tampe, Lauren Bizarro, Hikaru Sugimoto, Anna K. McGow, John M. Asara, Sara Lovisa, Kathleen M. McAndrews, Rafal Zielinski, Philip L. Lorenzi, Michael Zeisberg, Sughra Raza, Valerie S. LeBleu, Raghu Kalluri
Publikováno v:
Cell Reports, Vol 31, Iss 9, Pp - (2020)
Summary: The mechanistic contributions of cancer-associated fibroblasts (CAFs) in breast cancer progression remain to be fully understood. While altered glucose metabolism in CAFs could fuel cancer cells, how such metabolic reprogramming emerges and
Externí odkaz:
https://doaj.org/article/decc8e0c626e45a89fe21570ed6ec078
Autor:
Joyce T. O’Connell, Andrew J. Aguirre, Nina Ilic, John G. Doench, Ole Gjoerup, Ying Huang, Jonathan P. Rennhack, Andrew L. Hong, Andrew O. Giacomelli, Belinda Wang, William C. Hahn, Katherine Labella, Jessica A. Talamas, Annan Yang, Scott T. Younger, Evan Mun, Taylor E. Arnoff, Justin H. Hwang, Chao Dai, Ji Li, August Yue Huang, David E. Root, Maneesha Thaker
Publikováno v:
Cell reports
Cell Reports, Vol 36, Iss 4, Pp 109443-(2021)
Cell Reports, Vol 36, Iss 4, Pp 109443-(2021)
SUMMARY Metastasis is a complex and poorly understood process. In pancreatic cancer, loss of the transforming growth factor (TGF)-β/BMP effector SMAD4 is correlated with changes in altered histopathological transitions, metastatic disease, and poor
Autor:
Lev T. Perelman, Raghu Kalluri, Edward Vitkin, Cristina Ivan, Joyce T. O’Connell, Noritoshi Kato, Le Qiu, Anthony Lucci, Alberto Villanueva, George A. Calin, Sonia A. Melo, Carlos A. Melo, Hikaru Sugimoto, August Vidal
Publikováno v:
Cancer Cell. 26:707-721
SummaryExosomes are secreted by all cell types and contain proteins and nucleic acids. Here, we report that breast cancer associated exosomes contain microRNAs (miRNAs) associated with the RISC-Loading Complex (RLC) and display cell-independent capac
Autor:
Joyce T. O’Connell, Nathanael S. Gray, Casandra Chen, Oliver Jonas, John G. Doench, Mihir B. Doshi, Li Tan, Michael J. Cima, Matthew Whitman, William C. Hahn, Federica Piccioni, Robert Langer, Mikael L. Rinne, Jinhua Wang, Young Jin Ham, David E. Root, Yaara Zwang, Anthony Letai, Patrick Bhola, Hai-Tsang Huang
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::570c751fe20de259894fc30b16fe8035
https://doi.org/10.7554/elife.24523.023
https://doi.org/10.7554/elife.24523.023
Autor:
Harriet Wikman, Fernanda Machado de Carvalho, Karina N. Gonzalez Herrera, Raghu Kalluri, Ludmilla Thomé Domingos Chinen, Marcia C. Haigis, Joyce T. O’Connell, John M. Asara, Rafael Malagoli Rocha, Klaus Pantel, Valerie S. LeBleu, Aline Santos Damascena
Publikováno v:
Nature Cell Biology. 16:992-1003
Cancer cells can divert metabolites into anabolic pathways to support their rapid proliferation and to accumulate the cellular building blocks required for tumour growth. However, the specific bioenergetic profile of invasive and metastatic cancer ce
Autor:
Matthew Whitman, Joyce T. O’Connell, Mihir B. Doshi, Patrick Bhola, Li Tan, Jinhua Wang, Robert Langer, Anthony Letai, Oliver Jonas, Young Jin Ham, John G. Doench, Yaara Zwang, William C. Hahn, Casandra Chen, David E. Root, Nathanael S. Gray, Federica Piccioni, Mikael L. Rinne, Hai-Tsang Huang, Michael J. Cima
Publikováno v:
eLife
eLife, Vol 6 (2017)
eLife, Vol 6 (2017)
Activating mutations involving the PI3K pathway occur frequently in human cancers. However, PI3K inhibitors primarily induce cell cycle arrest, leaving a significant reservoir of tumor cells that may acquire or exhibit resistance. We searched for gen
Autor:
Alicia Y. Zhou, Joyce T. O’Connell, William C. Hahn, Eejung Kim, Rameen Beroukhim, Rhine R. Shen, Daniel Hagerstrand
Publikováno v:
Oncogene
Aberrant nuclear factor (NF)-κB activation is frequently observed in human cancers. Genome characterization efforts have identified genetic alterations in multiple components of the NF-κB pathway, some of which have been shown to be essential for c
Autor:
Hikaru Sugimoto, Müller Ca, Raghu Kalluri, Joyce T. O’Connell, David M. Charytan, Yingqi Teng, Valerie S. LeBleu, Gerhard A. Müller
Publikováno v:
Nature Medicine. 19:227-231
The functional contribution of myofibroblasts in fibrosis is not well understood. Using a new genetic mouse model to track and isolate myofibroblasts, we performed gene expression profiling followed by biological validation to identify HE4 (encoding
Autor:
Raghu Kalluri, Valerie S. LeBleu, Gangadhar Taduri, Craig B. Woda, Vesselina G. Cooke, Yingqi Teng, Hikaru Sugimoto, Joyce T. O’Connell
Publikováno v:
Nature medicine. 19(8)
Myofibroblasts are associated with organ fibrosis, but their precise origin and functional role remain unknown. We used multiple genetically engineered mice to track, fate map and ablate cells to determine the source and function of myofibroblasts in