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Biased TCR gene usage in alloreactive T cells specific for a structurally dissimilar MHC alloantigen
Autor:
Giovanna Lombardi, Joyce Lynch, Anna George, Sid Sidhu, Francesco Dazzi, Richard Batchelor, Robert I. Lechler, Federica M. Marelli
Publikováno v:
International Immunology. 6:1785-1790
Two models of allorecognition of MHC molecules have been proposed. One emphasizes specificity for MHC molecule-bound peptides and the other for exposed MHC polymorphisms. We predicted that the latter model would predominate in responder:stimulator co