Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Joyce L.W. Yau"'
Autor:
Joyce L.W. Yau, Jonathan R Seckl
Publikováno v:
Frontiers in Aging Neuroscience, Vol 4 (2012)
The hippocampus is a prime target for glucocorticoids (GCs) and a brain structure particularly vulnerable to ageing. Prolonged exposure to excess GCs compromises hippocampal electrophysiology, structure and function. Blood GC levels tend to increase
Externí odkaz:
https://doaj.org/article/ed788c658ed74d6ab9bdde9e042add85
Autor:
Joyce L.W. Yau, Scott P. Webster, Marian Joëls, Harm J. Krugers, Ming Zhou, Brian R. Walker, R. Angela Sarabdjitsingh, Jonathan R. Seckl
Publikováno v:
Neuropharmacology, 81, 231-236. Elsevier
11β-Hydroxysteroid dehydrogenase type 1 (11beta-HSD1) catalyzes intracellular regeneration of corticosterone and cortisol, thereby enhancing glucocorticoid action. Inhibition of 11β-HSD1 reverses the deficits in cognition with aging, a state of ele
Autor:
Anna Meljon, Ernest Arenas, Eylan Yutuc, Joyce L.W. Yau, William J. Griffiths, Spyridon Theofilopoulos, Peter J. Crick, Jonathan R. Seckl, Yuqin Wang
Publikováno v:
Biomolecules, Vol 9, Iss 4, p 149 (2019)
Biomolecules
Meljon, A, Crick, P J, Yutuc, E, Yau, J L, Seckl, J R, Theofilopoulos, S, Arenas, E, Wang, Y & Griffiths, W J 2019, ' Mining for Oxysterols in Cyp7b1-/-Mouse Brain and Plasma: Relevance to Spastic Paraplegia Type 5. ', Biomolecules, vol. 9, no. 4 . https://doi.org/10.3390/biom9040149
Meljon, A, Crick, P J, Yutuc, E, Yau, J L, Seckl, J R, Theofilopoulos, S, Arenas, E, Wang, Y & Griffiths, W J 2019, ' Mining for Oxysterols in Cyp7b1−/− Mouse Brain and Plasma: Relevance to Spastic Paraplegia Type 5 ', Biomolecules, vol. 9, no. 4, pp. 149 . https://doi.org/10.3390/biom9040149
Biomolecules
Meljon, A, Crick, P J, Yutuc, E, Yau, J L, Seckl, J R, Theofilopoulos, S, Arenas, E, Wang, Y & Griffiths, W J 2019, ' Mining for Oxysterols in Cyp7b1-/-Mouse Brain and Plasma: Relevance to Spastic Paraplegia Type 5. ', Biomolecules, vol. 9, no. 4 . https://doi.org/10.3390/biom9040149
Meljon, A, Crick, P J, Yutuc, E, Yau, J L, Seckl, J R, Theofilopoulos, S, Arenas, E, Wang, Y & Griffiths, W J 2019, ' Mining for Oxysterols in Cyp7b1−/− Mouse Brain and Plasma: Relevance to Spastic Paraplegia Type 5 ', Biomolecules, vol. 9, no. 4, pp. 149 . https://doi.org/10.3390/biom9040149
Deficiency in cytochrome P450 (CYP) 7B1, also known as oxysterol 7α-hydroxylase, in humans leads to hereditary spastic paraplegia type 5 (SPG5) and in some cases in infants to liver disease. SPG5 is medically characterized by loss of motor neurons i
Autor:
Stewart J. Jackson, Joyce L.W. Yau, Alasdair M.J. MacLullich, Tobias Bast, Gavin D. Merrifield, Ian Marshall, Rosalind Hussey, Maurits A. Jansen
Publikováno v:
Behavioural Brain Research. 216:293-300
Manganese (Mn2+)-enhanced magnetic resonance (MR) imaging (MEMRI) in rodents offers unique opportunities for the longitudinal study of hippocampal structure and function in parallel with cognitive testing. However, Mn2+ is a potent toxin and there is
Autor:
Jonathan R. Seckl, Margaret Binnie, June Noble, Joyce L.W. Yau, Brian R. Walker, Karen Sooy, Scott P. Webster
Publikováno v:
Sooy, K, Webster, S P, Noble, J, Binnie, M, Walker, B R, Seckl, J R & Yau, J L W 2010, ' Partial Deficiency or Short-Term Inhibition of 11β-Hydroxysteroid Dehydrogenase Type 1 Improves Cognitive Function in Aging Mice ', The Journal of Neuroscience, vol. 30, no. 41, pp. 13867-13872 . https://doi.org/10.1523/JNEUROSCI.2783-10.2010
11 beta-Hydroxysteroid dehydrogenase type 1 (11 beta-HSD1) regenerates active glucocorticoids (GCs) from intrinsically inert 11-keto substrates inside cells, including neurons, thus amplifying steroid action. Excess GC action exerts deleterious effec
Autor:
Malcolm R. Macleod, Jonathan R. Seckl, Megan C. Holmes, Karen Horsburgh, Dirk J. Stenvers, S. E. Bae, Christopher J. Kenyon, Joyce L.W. Yau, Maggie Lai, Celso E. Gomez-Sanchez, Roderick N. Carter, Jill H. Fowler
Publikováno v:
European Journal of Neuroscience. 25:1832-1842
The nuclear mineralocorticoid receptor (MR), a high-affinity receptor for glucocorticoids, is highly expressed in the hippocampus where it underpins cognitive, behavioural and neuroendocrine regulation. Increased neuronal MR expression occurs early i
Autor:
Rod Carter, June Noble, Donald R. Dunbar, Jing Qiu, Carolynn Cairns, Jonathan R. Seckl, Karen E. Chapman, Joyce L.W. Yau, Val Kelly
Publikováno v:
Qiu, J, Dunbar, D R, Noble, J, Cairns, C, Carter, R, Kelly, V, Chapman, K E, Seckl, J R & Yau, J L W 2015, ' Decreased Npas4 and Arc mRNA levels in the hippocampus of aged memory-impaired wild type but not memory preserved 11β-HSD1 deficient mice ', Journal of Neuroendocrinology, vol. 28, no. 1 . https://doi.org/10.1111/jne.12339
Journal of Neuroendocrinology
Journal of Neuroendocrinology
Mice deficient in the glucocorticoid-regenerating enzyme 11β-HSD1 resist age-related spatial memory impairment. To investigate the mechanisms and pathways involved, we used microarrays to identify differentially expressed hippocampal genes that asso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ce1b197cde950472d92dd2a20448f8c
https://hdl.handle.net/20.500.11820/8b5420c7-27d2-4c1d-ac3f-dcb909a6fdec
https://hdl.handle.net/20.500.11820/8b5420c7-27d2-4c1d-ac3f-dcb909a6fdec
Publikováno v:
Expert Review of Endocrinology & Metabolism. 1:527-536
Dementia care costs exceed those of cardiovascular diseases and cancer combined. Milder forms of functionally significant cognitive decline add further to the staggering human, societal and economic costs. However, the underlying mechanisms are poorl
Publikováno v:
Molecular Brain Research. 129:189-192
Adult rats were given antidepressant drugs orally. Fluoxetine, but not moclobemide, venlafaxine, tianeptine or desipramine, increased total glucocorticoid receptor (GR) mRNA in the hippocampus after 4 weeks. Further examination revealed that GR mRNA
Autor:
June Noble, Alasdair M.J. MacLullich, Ian J. Deary, Brian R. Walker, Joyce L.W. Yau, Thekkepat C. Sandeep, Jonathan R. Seckl
Publikováno v:
Proceedings of the National Academy of Sciences. 101:6734-6739
In aging humans and rodents, inter-individual differences in cognitive function have been ascribed to variations in long-term glucocorticoid exposure. 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) regenerates the active glucocorticoid cortisol