STOX1 deficiency is associated with renin-mediated gestational hypertension and placental defects

Autor: Jacqueline G. Parchem, Keizo Kanasaki, Soo Bong Lee, Megumi Kanasaki, Joyce L. Yang, Yong Xu, Kadeshia M. Earl, Rachel A. Keuls, Vincent H. Gattone II, Raghu Kalluri

Publikováno v: JCI Insight, Vol 6, Iss 2 (2021)

The pathogenesis of preeclampsia and other hypertensive disorders of pregnancy remains poorly defined despite the substantial burden of maternal and neonatal morbidity associated with these conditions. In particular, the role of genetic variants as d

Externí odkaz: https://doaj.org/article/4cc45d65458148de82efd4874b160229

Inference of CRISPR Edits from Sanger Trace Data

Autor: Hsiau T, Holden K, Joshi S, David Conant, Kelso R, Brittany L. Enzmann, Travis J. Maures, Joyce L. Yang, Stoner R, Kelsey Waite, Rossi N

Efficient precision genome editing requires a quick, quantitative, and inexpensive assay of editing outcomes. Here we present ICE (Inference of CRISPR Edits), which enables robust analysis of CRISPR edits using Sanger data. ICE proposes potential out

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::700585f6a31e207f231b2fe56b43e7e3

Highly Multiplexed Subcellular RNA Sequencing in Situ

Autor: Joyce L. Yang, Brian M. Turczyk, Adam H. Marblestone, Derek T. Peters, John Aach, Ryoji Amamoto, Samuel A. Inverso, Prashant Mali, Evan R. Daugharthy, Reza Kalhor, Thomas C. Ferrante, George M. Church, Je-Hyuk Lee, Amy Bernard, Jonathan Scheiman, Richard C. Terry, Chao Li, Xavier Rios, Sauveur S. F. Jeanty

Publikováno v: Science. 343:1360-1363

Transcripts Visualized in Situ Despite advances, current methods for single-cell sequencing are unable to resolve transcript location within the cell, so Lee et al. (p. 1360 , published online 27 February) developed a method of fluorescent in situ RN

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c8b46272fb38d5c82b75739dc19e9731
https://doi.org/10.1126/science.1250212

A public resource facilitating clinical use of genomes

Autor: John Aach, Euan A. Ashley, Je-Hyuk Lee, Hugh Y. Rienhoff, Matthew T. Wheeler, Jong Bhak, Peter J. Hulick, Joyce L. Yang, Carlos Cano, Radoje Drmanac, Jeong-Sun Seo, Jong Il Kim, Athurva Gore, Anugraha M. Raman, Zhe Li, Xiaodi Wu, Shawn M. Douglas, Michael F. Chou, Daniel B. Vorhaus, Jin Billy Li, Alberto Labarga, Michael F. Murray, Kimberly Robasky, Seong-Jin Kim, Byung Chul Kim, Leonid Peshkin, Luhan Yang, George M. Church, Misha Angrist, Joseph V. Thakuria, Preston W. Estep, Jeantine E. Lunshof, Christine E. Seidman, Madeleine Ball, Tom Clegg, Alexander Wait Zaranek, Abraham M. Rosenbaum, Brock A. Peters, Wendy K. Chung, Ward Vandewege, Heidi L. Rehm, Geoffrey B. Nilsen, Matthew J. Callow, Kun Zhang, Jason Bobe

Publikováno v: Ball, M P, Thakuria, J V, Zaranek, A W, Clegg, T, Rosenbaum, A M, Wu, X, Angrist, M, Bhak, J, Bobe, J, Callow, M J, Cano, C, Chou, M F, Chung, W K, Douglas, S M, Estep, P W, Gore, A, Hulick, P, Labarga, A, Lee, J-H, Lunshof, J E, Kim, B C, Kim, J L, Li, Z, Murray, M F, Nilsen, G B, Peters, B A, Raman, A M, Rienhoff, H Y, Robasky, K, Wheeler, M T, Vandewege, W, Vorhaus, D B, Yang, Y L, Yang, L, Aach, J, Ashley, E A, Drmanac, R, Kim, S-J, Li, J B, Peshkin, L, Seidman, S E, Seo, J-S, Zhang, K, Rehm, H L & Church, G M 2012, ' A public resource facilitating clinical use of genomes. ', Proceedings of the National Academy of Sciences of the United States of America, vol. 109, no. 30, pp. 11920-11927 . https://doi.org/10.1073/pnas.1201904109
Proceedings of the National Academy of Sciences of the United States of America, 109(30), 11920-11927. National Acad Sciences
Proceedings of the National Academy of Sciences of the United States of America, 109(30), 11920-11927. National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America, vol 109, iss 30

Rapid advances in DNA sequencing promise to enable new diagnostics and individualized therapies. Achieving personalized medicine, however, will require extensive research on highly reidentifiable, integrated datasets of genomic and health information

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47e2236be047d04a80fe8cbb08175d3e
https://research.vu.nl/en/publications/6e1a1cef-c7ef-4868-b615-c658b7a3ea72

Fluorescent in situ sequencing (FISSEQ) of RNA for gene expression profiling in intact cells and tissues

Autor: Thomas C. Ferrante, George M. Church, Jonathan Scheiman, Joyce L. Yang, Brian M. Turczyk, Reza Kalhor, Kun Zhang, Richard C. Terry, Evan R. Daugharthy, Hosuk Lee, John Aach, Je-Hyuk Lee

RNA-sequencing (RNA-seq) measures the quantitative change in gene expression over the whole transcriptome, but it lacks spatial context. In contrast, in situ hybridization provides the location of gene expression, but only for a small number of genes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26f8774dac3f27e2285eaaf46c30bb40
https://europepmc.org/articles/PMC4327781/