Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Joyce Kohler"'
Autor:
Kevin T. Chapman, Timothy A. Blizzard, Jiang Chang, Jerry D. Morgan, Ronald M. Kim, Ruth Kilburn, Milton L. Hammond, Joyce Kohler
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:849-852
A series of G6-amino derivatives of a lipophilic vancomycin analogue was prepared. Antibacterial activity of the analogues was inversely proportional to the degree of substitution of the G6-nitrogen. The fully substituted (quaternary) analogues were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee8193d2ad86e4c9ceb89908ae5ac488
https://doi.org/10.1016/s0960-894x(02)00049-5
https://doi.org/10.1016/s0960-894x(02)00049-5
Autor:
Hugh Rosen, Karen Dorso, Gail G. Hammond, Helmut Kropp, Lynn L. Silver, Katherine Young, Joyce Kohler
Publikováno v:
Antimicrobial Agents and Chemotherapy. 43:1170-1176
An important mechanism of bacterial resistance to β-lactam antibiotics is inactivation by β-lactam-hydrolyzing enzymes (β-lactamases). The evolution of the extended-spectrum β-lactamases (ESBLs) is associated with extensive use of β-lactam antib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e4e07144790eac49702cbdc3f9c040a3
https://doi.org/10.1128/aac.43.5.1170
https://doi.org/10.1128/aac.43.5.1170
Autor:
James V. Heck, John W. Kozarich, Lynn L. Silver, Joyce Kohler, R Thompson, Charles Gill, Frank P. DiNinno, Joann Huber, Hugh Rosen, Robert R. Wilkening, Jeffrey H. Epstein-Toney, Jon G. Sundelof, Barbara A. Pelak, Karen Dorso, Richard Hajdu, Gail G. Hammond, Kenneth J. Wildonger, Helmut Kropp, Timothy A. Blizzard, Jesse J. Jackson, Ronald W. Ratcliffe, Milton L. Hammond, George R. Lankas
Publikováno v:
Science. 283:703-706
A carbapenem antibiotic, L-786,392, was designed so that the side chain that provides high-affinity binding to the penicillin-binding proteins responsible for bacterial resistance was also the structural basis for ameliorating immunopathology. Expuls
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bec914fb7884fd84749274c4d2abcccc
https://doi.org/10.1126/science.283.5402.703
https://doi.org/10.1126/science.283.5402.703
Autor:
Jon G. Sundelof, Earl St. Rose, Kenneth J. Wildonger, Karen Dorso, Timothy A. Blizzard, Sandra P. Szumiloski, Ronald W. Ratcliffe, Sherman T. Waddell, Joyce Kohler, Joann Huber, Robert R. Wilkening, Gail G. Hammond
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:1427-1432
A series of sulfur-linked benzothiazolyl carbapenems has been prepared and evaluated against a battery of microorganisms. Many of the compounds displayed good activity against methicillin-resistant Staphylococcus aureus (MRSA). Data is presented whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f3e7c77a7ce92529b58445a9083e9a7f
https://doi.org/10.1016/0960-894x(95)00235-l
https://doi.org/10.1016/0960-894x(95)00235-l
Autor:
Sandra P. Szumiloski, Gail G. Hammond, Joyce Kohler, Earl St. Rose, Kenneth J. Wildonger, Timothy A. Blizzard, Sherman T. Waddell, Robert R. Wilkening, Jon G. Sundelof, Karen Dorso, Joann Huber, Ronald W. Ratcliffe
Publikováno v:
ChemInform. 26
A series of sulfur-linked benzothiazolyl carbapenems has been prepared and evaluated against a battery of microorganisms. Many of the compounds displayed good activity against methicillin-resistant Staphylococcus aureus (MRSA). Data is presented whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5a4837781399af25e1733bfc5e98571
https://doi.org/10.1002/chin.199544260
https://doi.org/10.1002/chin.199544260
Autor:
Ronald M. Kim, Jerry D. Morgan, Kevin T. Chapman, Joyce Kohler, Milton L. Hammond, Ruth Kilburn, Jiang Chang, Timothy A. Blizzard
Publikováno v:
ChemInform. 33
A series of G6-amino derivatives of a lipophilic vancomycin analogue was prepared. Antibacterial activity of the analogues was inversely proportional to the degree of substitution of the G6-nitrogen. The fully substituted (quaternary) analogues were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e9ef96ff71699847551beffd646db222
https://doi.org/10.1002/chin.200227257
https://doi.org/10.1002/chin.200227257
Autor:
Seketsu Fukuzawa, Zhong Chen, Lynn L. Silver, Daniel Kahne, Christopher Thompson, Robert Kerns, Onishi, Joyce Kohler, Min Ge, H. Russell
Publikováno v:
Science (New York, N.Y.). 284(5413)
Vancomycin is an important drug for the treatment of Gram-positive bacterial infections. Resistance to vancomycin has begun to appear, posing a serious public health threat. Vancomycin analogs containing modified carbohydrates are very active against
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3057625c3498381c9bb3ac235d8b383
https://pubmed.ncbi.nlm.nih.gov/10232990
https://pubmed.ncbi.nlm.nih.gov/10232990
Autor:
Gail G. Hammond, J.V. Heck, Dann L. Parker, Timothy A. Blizzard, Kenneth J. Wildonger, Jon G. Sundelof, Walter J. May, Ronald W. Ratcliffe, Sherman T. Waddell, Robert R. Wilkening, Milton L. Hammond, Joanne Huber, Karen Dorso, Gina M. Santorelli, Joyce Kohler, E. St. Rose, Jerry D. Morgan
Publikováno v:
Bioorganicmedicinal chemistry letters. 9(5)
A series of 1beta-methyl-2-(naphthosultamyl)methyl-carbapenems bearing dicationic groups on the naphthosultamyl moiety was prepared and evaluated for activity against resistant gram-positive bacteria. Based on a combination of excellent in vitro anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9353b784213659ca2ff75dda56845d1
https://pubmed.ncbi.nlm.nih.gov/10201828
https://pubmed.ncbi.nlm.nih.gov/10201828
Autor:
Gail G. Hammond, Karen Dorso, Kevin D. Dykstra, Timothy A. Blizzard, J.V. Heck, Kenneth J. Wildonger, Lovji D. Cama, Ronald W. Ratcliffe, E. St. Rose, Joyce Kohler, Frank P. DiNinno, Robert R. Wilkening, Milton L. Hammond
Publikováno v:
Bioorganicmedicinal chemistry letters. 9(5)
A series of 1beta-methyl carbapenems substituted at the 2-position with lipophilic, acyclic and cyclic (sulfonamido)methyl groups was prepared and evaluated for activity against resistant gram-positive bacteria. From these studies, the 1,8-naphthosul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39798dddb79d76bf5f63ae4315e4cdb8
https://pubmed.ncbi.nlm.nih.gov/10201827
https://pubmed.ncbi.nlm.nih.gov/10201827
Autor:
Jeffrey D. Carbeck, and Lynn Silver, Steven D Dong, Robert Kerns, Seketsu Fukuzawa, Joyce Kohler, Daniel Kahne
Publikováno v:
Journal of the American Chemical Society. 122:12608-12609
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::165ac066d4741692490580b05ccfc6bb
https://doi.org/10.1021/ja0027665
https://doi.org/10.1021/ja0027665