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Autor:
Raouf A. Hussain, Joyce K. Dickey, Maria L. Webb, Prabhavathi B. Fernandes, Patricia M. Rose, Michael R. Kozlowski, James A. Matson, Russell J. Brittain, Mary P. Rosser
Publikováno v:
Journal of Natural Products. 58:1515-1520
Fractionation of an extract of Phyllanthus niruri, based on its ability to inhibit [ 125 I]-ET-1 binding to A10 cells (rat thoracic aortic smooth muscle cells), led to the isolation of three non-peptidic endothelin-1 (ET-1) antagonists, which have be