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VSV-G Pseudotyped Lentiviral Vector Particles Produced in Human Cells Are Inactivated by Human Serum
Autor:
Philip Lee Sheridan, Nicholas J. DePolo, Sybille L. Sauter, Kay Townsend, Joyce D. Reed, Thomas W. Dubensky, Douglas J. Jolly
Publikováno v:
Molecular Therapy. 2:218-222
Lentiviral vectors transduce dividing and postmitotic cells and thus are being developed toward therapies for many diseases affecting diverse tissues. One essential requirement for efficacy will be that vector particles are resistant to inactivation