Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Joyce Cheung"'
Autor:
Jamie E. Meegan, Padmini Komalavilas, Joyce Cheung‐Flynn, Tsz Wing Yim, Nathan D. Putz, Jordan J. Jesse, Kyle D. Smith, Tatiana N. Sidorova, Han Noo Ri Lee, Toria Tomasek, Ciara M. Shaver, Lorraine B. Ware, Colleen M. Brophy, Julie A. Bastarache
Publikováno v:
Physiological Reports, Vol 10, Iss 11, Pp n/a-n/a (2022)
Abstract Sepsis is a devastating disease with high morbidity and mortality and no specific treatments. The pathophysiology of sepsis involves a hyperinflammatory response and release of damage‐associated molecular patterns (DAMPs), including adenos
Externí odkaz:
https://doaj.org/article/c442a96d140a4867a2a4fce0591bff3d
Autor:
Brian C. Evans, R. Brock Fletcher, Kameron V. Kilchrist, Eric A. Dailing, Alvin J. Mukalel, Juan M. Colazo, Matthew Oliver, Joyce Cheung-Flynn, Colleen M. Brophy, John W. Tierney, Jeffrey S. Isenberg, Kurt D. Hankenson, Kedar Ghimire, Cynthia Lander, Charles A. Gersbach, Craig L. Duvall
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
Most reagents designed to deliver cargo into cells are cationic and so cannot deliver cationic cargo. Here the authors show that pretreating cells with the anionic polymer poly(propylacrylic acid) facilitates the uptake and endosomal escape of a wide
Externí odkaz:
https://doaj.org/article/527a6ef95d124979b5fd95a610cb9fb1
Autor:
J. William Tierney, Brian C. Evans, Joyce Cheung-Flynn, Bo Wang, Juan M. Colazo, Monica E. Polcz, Rebecca S. Cook, Colleen M. Brophy, Craig L. Duvall
Publikováno v:
JCI Insight, Vol 6, Iss 19 (2021)
Vascular procedures, such as stenting, angioplasty, and bypass grafting, often fail due to intimal hyperplasia (IH), wherein contractile vascular smooth muscle cells (VSMCs) dedifferentiate to synthetic VSMCs, which are highly proliferative, migrator
Externí odkaz:
https://doaj.org/article/342ff646c4854f9ab16bc9c7e294d943
Autor:
Jamie E Meegan, Ciara M Shaver, Nathan D Putz, Jordan J Jesse, Stuart R Landstreet, Han Noo Ri Lee, Tatiana N Sidorova, J Brennan McNeil, James L Wynn, Joyce Cheung-Flynn, Padmini Komalavilas, Colleen M Brophy, Lorraine B Ware, Julie A Bastarache
Publikováno v:
PLoS ONE, Vol 15, Iss 2, p e0228727 (2020)
Increased endothelial permeability is central to the pathogenesis of sepsis and leads to organ dysfunction and death but the endogenous mechanisms that drive increased endothelial permeability are not completely understood. We previously reported tha
Externí odkaz:
https://doaj.org/article/e068d1cb04d84396b01306e30f41f480
Autor:
Joyce Cheung-Flynn, Bret D Alvis, Kyle M Hocking, Christy M Guth, Weifeng Luo, Reid McCallister, Kalyan Chadalavada, Monica Polcz, Padmini Komalavilas, Colleen M Brophy
Publikováno v:
PLoS ONE, Vol 14, Iss 8, p e0220893 (2019)
Resuscitation with 0.9% Normal Saline (NS), a non-buffered acidic solution, leads to increased morbidity and mortality in the critically ill. The goal of this study was to determine the molecular mechanisms of endothelial injury after exposure to NS.
Externí odkaz:
https://doaj.org/article/78435475be7d420db703e78bcbdcb4c9
Autor:
Padmini Komalavilas, Weifeng Luo, Christy M Guth, Olukemi Jolayemi, Rachel I Bartelson, Joyce Cheung-Flynn, Colleen M Brophy
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0188069 (2017)
A viable vascular endothelial layer prevents vasomotor dysfunction, thrombosis, inflammation, and intimal hyperplasia. Injury to the endothelium occurs during harvest and "back table" preparation of human saphenous vein prior to implantation as an ar
Externí odkaz:
https://doaj.org/article/367a56309adf4bba9ee9f3328d1a4676
Autor:
Weifeng Luo, Christy M Guth, Olukemi Jolayemi, Craig L Duvall, Colleen Marie Brophy, Joyce Cheung-Flynn
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 4 (2016)
Vascular stretch injury is associated with blunt trauma, vascular surgical procedures, and harvest of human saphenous vein for use in vascular bypass grafting. A model of subfailure overstretch in rat abdominal aorta was developed to characterize sur
Externí odkaz:
https://doaj.org/article/07bc0100ecc4488a9f8d77931888f423
Autor:
Kyle M Hocking, Gowthami Putumbaka, Eric S Wise, Joyce Cheung-Flynn, Colleen M Brophy, Padmini Komalavilas
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0154460 (2016)
OBJECTIVE:Papaverine is used to prevent vasospasm in human saphenous veins (HSV) during vein graft preparation prior to implantation as a bypass conduit. Papaverine is a nonspecific inhibitor of phosphodiesterases, leading to increases in both intrac
Externí odkaz:
https://doaj.org/article/e27695ad66304baeab45c9279ff15ebd
Autor:
Kyle M Hocking, Franz J Baudenbacher, Gowthami Putumbaka, Sneha Venkatraman, Joyce Cheung-Flynn, Colleen M Brophy, Padmini Komalavilas
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e60986 (2013)
Initiation of force generation during vascular smooth muscle contraction involves a rise in intracellular calcium ([Ca(2+)]i) and phosphorylation of myosin light chains (MLC). However, reversal of these two processes alone does not account for the fo
Externí odkaz:
https://doaj.org/article/0293527975d348ff9b9a66f998614143
Autor:
John C O'Leary, Sheetal Dharia, Laura J Blair, Sarah Brady, Amelia G Johnson, Melinda Peters, Joyce Cheung-Flynn, Marc B Cox, Gabriel de Erausquin, Edwin J Weeber, Umesh K Jinwal, Chad A Dickey
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e24840 (2011)
The gene FKBP5 codes for FKBP51, a co-chaperone protein of the Hsp90 complex that increases with age. Through its association with Hsp90, FKBP51 regulates the glucocorticoid receptor (GR). Single nucleotide polymorphisms (SNPs) in the FKBP5 gene asso
Externí odkaz:
https://doaj.org/article/c5523d7959a047feb75cf7ab762184ef