Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Joyce C. Knutson"'
Publikováno v:
Journal of Bone and Mineral Research. 9:607-614
This study is the first reported administration of 1α-hydroxyvitamin D2 (1α-OHD2) to human subjects. A total of 15 postmenopausal osteopenic women were given increasing oral doses of 1α-OHD2, beginning with a low dose of 0.5 μg/day. In 15 subject
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bdfd896772d1495199435aa0ce42942
https://doi.org/10.1002/jbmr.5650090504
https://doi.org/10.1002/jbmr.5650090504
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1761:221-234
While current dogma argues that vitamin D prodrugs require side-chain activation by liver enzymes, recent data suggest that hydroxylation may also occur extrahepatically. We used keratinocytes and recombinant human enzyme to test if the 25-hydroxyvit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c46a580f80ca201f537d79223b1631e6
https://doi.org/10.1016/j.bbalip.2006.01.004
https://doi.org/10.1016/j.bbalip.2006.01.004
Publikováno v:
Nephrology Dialysis Transplantation. 21:644-650
BACKGROUND: Active vitamin D compounds are widely used in the treatment of secondary hyperparathyroidism associated with renal failure. These compounds reduce PTH secretion through vitamin D receptor (VDR)-dependent repression of PTH gene transcripti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdde6f27bb7ad48a9e4ddcae30463e39
https://doi.org/10.1093/ndt/gfi186
https://doi.org/10.1093/ndt/gfi186
Publikováno v:
Biochemical Pharmacology. 68:1289-1296
The active vitamin D compound 1alpha,24(S)-dihydroxyvitamin D(2) (1,24(OH)(2)D(2)) is under development as a therapy for disorders including cancer and secondary hyperparathyroidism. 1,24(OH)(2)D(2) is a potent inhibitor of cell proliferation in vitr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8aa6125e5f7d36a2817fe7328325650e
https://doi.org/10.1016/j.bcp.2004.06.015
https://doi.org/10.1016/j.bcp.2004.06.015
Autor:
Brian T. Gregg, Zinovy Itov, Mark A Helle, Harold Meckler, Joyce C. Knutson, Mary E. Mateo, William B. Geiss, Lisa D. Coutts, Mark W. Zettler, Chi-Hsin R. King
Publikováno v:
Organic Process Research & Development. 6:246-255
This contribution describes the first stereospecific synthesis of 24(S)-hydroxyvitamin D2 (1), a metabolite of vitamin D2. This metabolite acts as a prodrug for 1α,24(S)-dihydroxyvitamin D2 (2), wh...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c16f7c550721591c31a7e8dd9c2db36b
https://doi.org/10.1021/op010229e
https://doi.org/10.1021/op010229e
Autor:
E. Barbara Mawer, Glenville Jones, Valarie Byford, Michael Davies, Joyce C. Knutson, Neil J. Schroeder, Pamela E. Still, Hugh L.J. Makin, Charles W. Bishop
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 83:2156-2166
We have produced evidence for a new metabolic pathway for vitamin D2 in humans involving the production of 24-hydroxyvitamin D2 (24OHD2) and 1,24-dihydroxyvitamin D2 [1,24-(OH)2D2]. These metabolites were produced after either a single large dose (10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7d4cb95f7c6f3e585d7a50419adb09d
https://doi.org/10.1210/jcem.83.6.4841
https://doi.org/10.1210/jcem.83.6.4841
Autor:
Glenville Jones, Joyce C. Knutson, Hugh L.J. Makin, Charles W. Bishop, Robert H. Rice, Lea Ann deGraffenried, Richard Kremer, Valarie Byford
Publikováno v:
Biochemical Pharmacology. 52:133-140
Vitamin D analogs represent valuable new agents for the suppression of proliferation of a variety of cell types, including those of the skin. One such analog is the vitamin D 2 metabolite, 1 α ,24( S )-dihydroxyvitamin D 2 , which binds strongly to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33c3c15c987ff402304102f200e29063
https://doi.org/10.1016/0006-2952(96)00173-6
https://doi.org/10.1016/0006-2952(96)00173-6
Autor:
Glenville, Jones, Valarie, Byford, Shelly, West, Sonoko, Masuda, George, Ibrahim, Martin, Kaufmann, Joyce C, Knutson, Stephen, Strugnell, Rajendra, Mehta
Publikováno v:
Anticancer research. 26(4A)
Like most pharmaceutical agents, vitamin D analogs are subject to hepatic metabolism by a variety of cytochrome P450 (CYP)-based systems. Metabolism can involve activation as well as inactivation of the vitamin D analog and one of the more successful
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::63455e6dec3a895694f374a34379f505
https://pubmed.ncbi.nlm.nih.gov/16886668
https://pubmed.ncbi.nlm.nih.gov/16886668
Autor:
Glendon M, Zinser, Emily, Tribble, Meggan, Valrance, Colleen M, Urben, Joyce C, Knutson, Richard B, Mazess, Stephen A, Strugnell, Joellen, Welsh
Publikováno v:
Anticancer research. 25(1A)
1,24-Dihydroxyvitamin D2 (1,24(OH)2D2) is a naturally occurring metabolite of vitamin D2 with low calcemic activity and potent antiproliferative activity. We evaluated the activity of 1,24(OH)2D2 in breast cancer models.The antiproliferative activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::873b69094778b858bdaa8ce7dd6c0afa
https://pubmed.ncbi.nlm.nih.gov/15816543
https://pubmed.ncbi.nlm.nih.gov/15816543
Autor:
Joyce C. Knutson, Martin Kaufmann, Mian Gao, Sonoko Masuda, René St-Arnaud, Stephen Strugnell, H.L.J. Makin, Valarie Byford, Alice Arabian, Glenville Jones
Publikováno v:
The Journal of steroid biochemistry and molecular biology. (1-5)
The development of novel gene expression systems for cytochrome P450s (CYPs) together with a revolution in analytical mass spectrometry with the emergence of liquid chromatography/mass spectrometry (LC/MS) has opened the door to answering some long-s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7daebf0af5282b18470c8b270c2c682
https://pubmed.ncbi.nlm.nih.gov/15225763
https://pubmed.ncbi.nlm.nih.gov/15225763