Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Joyce C K Man"'
Autor:
Joyce C. K. Man, Rajiv A. Mohan, Malou van den Boogaard, Catharina R. E. Hilvering, Catherine Jenkins, Vincent Wakker, Valerio Bianchi, Wouter de Laat, Phil Barnett, Bastiaan J. Boukens, Vincent M. Christoffels
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Mutations associated with SCN5A, which encodes the major cardiac sodium channel, influence impulse conduction and are associated with arrhythmia disorders. Here, the authors identify an evolutionary conserved, super enhancer-like, regulatory cluster
Externí odkaz:
https://doaj.org/article/cb64f996f52046f4a1729c8c928335c9
Autor:
Vincent M. Christoffels, James F. Martin, Ingeborg B. Hooijkaas, Jeroen Bakkers, Petra van der Kraak, Dennis E. M. de Bakker, Rob Janssen, Matthew C. Hill, Phil Barnett, Karel van Duijvenboden, Esther E. Creemers, Marie Günthel, Ingeborg van der Made, Joyce C K Man, Aryan Vink
Publikováno v:
Circulation, 140(10), 864-879. Lippincott Williams and Wilkins
Circulation, 140(10), 864-879. Lippincott Williams & Wilkins
Circulation, 140(10), 864-879. Lippincott Williams & Wilkins
Background: Surviving cells in the postinfarction border zone are subjected to intense fluctuations of their microenvironment. Recently, border zone cardiomyocytes have been specifically implicated in cardiac regeneration. Here, we defined their uniq
Autor:
Joyce C K, Man, Fernanda M, Bosada, Koen T, Scholman, Joost A, Offerhaus, Roddy, Walsh, Karel, van Duijvenboden, Vincent W W, van Eif, Connie R, Bezzina, Arie O, Verkerk, Bastiaan J, Boukens, Phil, Barnett, Vincent M, Christoffels
Publikováno v:
Circulation. 144(3)
Genetic variants inThe expression ofWe found that cardiomyocytes of the atria, sinoatrial node, and ventricular conduction system express a short transcript comprising the last 7 exons of the gene (Genetic variants in and around
Autor:
Phil Barnett, Vincent M. Christoffels, Vincent W. W. van Eif, Arie O. Verkerk, Bastiaan J. Boukens, Joyce C K Man, Roddy Walsh, Joost A. Offerhaus, Karel van Duijvenboden, Connie R. Bezzina, Fernanda M Bosada, Koen T. Scholman
Publikováno v:
Circulation, 144(3), 229-242. Lippincott Williams and Wilkins
Background: Genetic variants in SCN10A , encoding the neuronal voltage-gated sodium channel Na V 1.8, are strongly associated with atrial fibrillation, Brugada syndrome, cardiac conduction velocities, and heart rate. The cardiac function of SCN10A ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbb7cb1cc013bb5c89125cc00192a864
https://pure.amc.nl/en/publications/variant-intronic-enhancer-controls-scn10ashort-expression-and-heart-conduction(24be2388-290f-45b0-bd1e-8ab79dcd42f6).html
https://pure.amc.nl/en/publications/variant-intronic-enhancer-controls-scn10ashort-expression-and-heart-conduction(24be2388-290f-45b0-bd1e-8ab79dcd42f6).html
Autor:
Joyce C K, Man, Karel, van Duijvenboden, Peter H L, Krijger, Ingeborg B, Hooijkaas, Ingeborg, van der Made, Corrie, de Gier-de Vries, Vincent, Wakker, Esther E, Creemers, Wouter, de Laat, Bastiaan J, Boukens, Vincent M, Christoffels
Publikováno v:
Circ Res
ANP (atrial natriuretic peptide) and BNP (B-type natriuretic peptide), encoded by the clustered genesTo explore the physiological functions of the enhancer cluster and elucidate the genomic mechanism underlyingBy analyzing epigenetic data we uncovere
Autor:
Esther E. Creemers, Vincent Wakker, Peter Hl L. Krijger, Corrie de Gier-de Vries, Vincent M. Christoffels, Wouter de Laat, Karel van Duijvenboden, Ingeborg van der Made, Joyce C K Man, Ingeborg B. Hooijkaas, Bastiaan J. Boukens
Publikováno v:
Circulation Research. Lippincott Williams & Wilkins
Circulation research, 128(1), 115-129. Lippincott Williams and Wilkins
Circulation research, 128(1), 115-129. Lippincott Williams and Wilkins
Rationale: ANP (atrial natriuretic peptide) and BNP (B-type natriuretic peptide), encoded by the clustered genes Nppa and Nppb , are important prognostic, diagnostic, and therapeutic proteins in cardiac disease. The spatiotemporal expression pattern
Autor:
Vincent Wakker, Valerio Bianchi, Malou van den Boogaard, Wouter de Laat, Bastiaan J. Boukens, Vincent M. Christoffels, Rajiv A Mohan, Joyce C K Man, Catharina R.E. Hilvering, Catherine Jenkins, Phil Barnett
Publikováno v:
Nature communications, 10(1). Nature Publishing Group
Nature Communications, 10(1). Nature Publishing Group
Nature Communications, 10(1):4943. Nature Publishing Group
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature Communications
Nature Communications, 10(1). Nature Publishing Group
Nature Communications, 10(1):4943. Nature Publishing Group
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature Communications
Mutations and variations in and around SCN5A, encoding the major cardiac sodium channel, influence impulse conduction and are associated with a broad spectrum of arrhythmia disorders. Here, we identify an evolutionary conserved regulatory cluster wit
Autor:
Ralph G. Tieland, Paul M.P. van Bergen en Henegouwen, Marcel A.G. van der Heyden, Hiroki Takanari, Joyce C K Man, Raimond Heukers, Marc A. Vos, Rosanne Varkevisser, Maaike Waasdorp, Marien J C Houtman
Publikováno v:
Pflügers Archiv European Journal of Physiology, 465(2), 247-59. Springer Verlag
Varkevisser, R, Houtman, M J C, Waasdorp, M, Man, J C K, Heukers, R, Takanari, H, Tieland, R G, van Bergen En Henegouwen, P M P, Vos, M A & van der Heyden, M A G 2013, ' Inhibiting the clathrin-mediated endocytosis pathway rescues K(IR)2.1 downregulation by pentamidine ', Pflügers Archiv European Journal of Physiology, vol. 465, no. 2, pp. 247-59 . https://doi.org/10.1007/s00424-012-1189-5
Pflügers Archiv-European Journal of Physiology; Vol 465
Varkevisser, R, Houtman, M J C, Waasdorp, M, Man, J C K, Heukers, R, Takanari, H, Tieland, R G, van Bergen En Henegouwen, P M P, Vos, M A & van der Heyden, M A G 2013, ' Inhibiting the clathrin-mediated endocytosis pathway rescues K(IR)2.1 downregulation by pentamidine ', Pflügers Archiv European Journal of Physiology, vol. 465, no. 2, pp. 247-59 . https://doi.org/10.1007/s00424-012-1189-5
Pflügers Archiv-European Journal of Physiology; Vol 465
Drug-induced ion channel trafficking disturbance can cause cardiac arrhythmias. We showed that the antiprotozoic pentamidine decreased K(IR)2.x carried I(K1) current and that inhibiting protein degradation in the lysosome increased intracellular K(IR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b3c833110f9394c415865a9a2778b45
https://research.vu.nl/en/publications/26941a9e-aafe-4a24-9287-61a51356776e
https://research.vu.nl/en/publications/26941a9e-aafe-4a24-9287-61a51356776e