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Autor:
Michael A. Poss, and Thomas P. Kissick, Michael J. Humora, Pansegrau Paul D, Boyhan Brenda T, Richard H. Mueller, John K. Thottathil, Shaopeng Wang, Janak Singh, Joy Q. Jannotti
Publikováno v:
Organic Process Research & Development. 1:14-19
A novel and highly efficient synthesis of [1S-(1α,2α,3α,4α)]-2-[[2-(3-methoxy-3-oxopropyl)phenyl]methyl]-7-oxabicyclo[2.2.1]heptane-3-carboxylic acid (A), a key intermediate in the synthesis of ifetroban sodium, BMS-180291, is described. Reaction