Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Joy Loh"'
Autor:
Joy Loh, Qiulong Huang, Andrew M Petros, David Nettesheim, Linda F van Dyk, Lucia Labrada, Samuel H Speck, Beth Levine, Edward T Olejniczak, Herbert W Virgin
Publikováno v:
PLoS Pathogens, Vol 1, Iss 1, p e10 (2005)
Antiapoptotic Bcl-2 family proteins inhibit apoptosis in cultured cells by binding BH3 domains of proapoptotic Bcl-2 family members via a hydrophobic BH3 binding groove on the protein surface. We investigated the physiological importance of the BH3 b
Externí odkaz:
https://doaj.org/article/ab77daa81cbe4a85ab9e3b2219e4f498
Autor:
Thaddeus S. Stappenbeck, Henry V. Huang, Herbert W. Virgin, Guoyan Zhao, Larissa B. Thackray, Joy Loh, David Wang, Christine C. Yokoyama
Publikováno v:
Journal of Virology. 86:12262-12270
The mechanisms of astrovirus pathogenesis are largely unknown, in part due to a lack of a small-animal model of disease. Using shotgun sequencing and a custom analysis pipeline, we identified two novel astroviruses capable of infecting research mice,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a04e68dbf22fd99fb6fee7876583c56b
https://doi.org/10.1128/jvi.02018-12
https://doi.org/10.1128/jvi.02018-12
Publikováno v:
Journal of Biological Chemistry. 287:14467-14479
Viral immune invasion proteins are highly effective probes for studying physiological pathways. We report here the characterization of a new viral ubiquitin ligase pK3 expressed by rodent herpesvirus Peru (RHVP) that establishes acute and latent infe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30ad98868d011acc53084a67d7ed79ce
https://doi.org/10.1074/jbc.m111.325340
https://doi.org/10.1074/jbc.m111.325340
Autor:
Jill K. Fisher, Milton Packer, Z. H. An, Kai Sun, Joy Loh, Qihua Sun, Rhonda Bassel-Duby, Joseph A. Hill, Stanley J. Korsmeyer, Christopher J. Gilpin, Herman I. May, Herbert W. Virgin, Viviana Moresi, Michael C. Bassik, Zhongju Zou, Congcong He, Yongjie Wei, Beth Levine, Philipp E. Scherer, Guanghua Xiao
Publikováno v:
Nature. 481:511-515
Exercise has beneficial effects on human health, including protection against metabolic disorders such as diabetes1. However, the cellular mechanisms underlying these effects are incompletely understood. The lysosomal degradation pathway, autophagy,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1c0f0d0ebfd5822410040e2201324fc
https://doi.org/10.1038/nature10758
https://doi.org/10.1038/nature10758
Autor:
Davies, Rupert1 (AUTHOR), Peng, Stanford L.1 (AUTHOR), Lickliter, Jason2 (AUTHOR), McLendon, Kristi3 (AUTHOR), Enstrom, Amanda1 (AUTHOR), Chunyk, Allison G.1 (AUTHOR), Blanchfield, Lori1 (AUTHOR), Wang, NingXin1 (AUTHOR) rachel_wang@vrtx.com, Blair, Tiffany1 (AUTHOR), Thomas, Heather M.1 (AUTHOR), Smith, Alina1 (AUTHOR), Dillon, Stacey R.1 (AUTHOR) stacey_dillon@vrtx.com
Publikováno v:
CTS: Clinical & Translational Science. Nov2024, Vol. 17 Issue 11, p1-15. 15p.
Publikováno v:
Journal of Virology. 78:12519-12528
Gammaherpesviruses can establish lifelong latent infections in lymphoid cells of their hosts despite active antiviral immunity. Identification of the immune mechanisms which regulate gammaherpesvirus latent infection is therefore essential for unders
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87814d6f00220d3ab0bf5122ac6a510a
https://doi.org/10.1128/jvi.78.22.12519-12528.2004
https://doi.org/10.1128/jvi.78.22.12519-12528.2004
Autor:
Erik S. Barton, Herbert W. Virgin, Yiyue Ma, Fuan Wang, Grant McFadden, John W. Barrett, Xiujuan Gao, Joy Loh
Publikováno v:
Nature Immunology. 5:1266-1274
Myxoma virus, a member of the poxvirus family, causes lethal infection only in rabbits, but the mechanism underlying the strict myxoma virus species barrier is not known. Here we show that myxoma virus infection of primary mouse embryo fibroblasts el
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5728b9f58bb73cbef9d0c25fbd5e6fd
https://doi.org/10.1038/ni1132
https://doi.org/10.1038/ni1132
Autor:
Sharookh B. Kapadia, Scott A. Tibbetts, Herbert W. Virgin, Victor van Berkel, James Scott McClellan, Joy Loh, Meagan A. Jacoby, Samuel H. Speck
Publikováno v:
Journal of Virology. 77:7696-7701
Gammaherpesviruses such as Epstein-Barr virus and Kaposi's sarcoma-associated herpesvirus are important human pathogens that establish long-term latent infections. Understanding of the initiation and maintenance of latent infections has important imp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba14ba3f00ba19b04f68be98c0ca0273
https://doi.org/10.1128/jvi.77.13.7696-7701.2003
https://doi.org/10.1128/jvi.77.13.7696-7701.2003
Autor:
Lindsay Droit, Nancy B. Myers, Joy Loh, Guoyan Zhao, Daniel L. Popkin, Punit Vachharajani, Ted H. Hansen, Xin Zhang, Douglas C. Braaten, Herbert W. Virgin
Herpesviruses are thought to be highly genetically stable, and their use as vaccine vectors has been proposed. However, studies of the human gammaherpesvirus, Epstein-Barr virus, have found viral isolates containing mutations in HLA class I-restricte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41714c3b34fb4cf57ff076bcc9dea478
https://europepmc.org/articles/PMC3302239/
https://europepmc.org/articles/PMC3302239/
Autor:
Herbert W. Virgin, Scott A. Handley, Hilda Guzman, David Wang, Guoyan Zhao, L. Steven Johnson, Penny Coder, Punit Vachharajani, Lindsay Droit, Robert B. Tesh, Joy Loh, Christopher A. Nelson, Daved H. Fremont
Gammaherpesviruses encode numerous immunomodulatory molecules that contribute to their ability to evade the host immune response and establish persistent, lifelong infections. As the human gammaherpesviruses are strictly species specific, small anima
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b32b5deb14aa60d55b0ecfb1a3c21d07
https://europepmc.org/articles/PMC3067950/
https://europepmc.org/articles/PMC3067950/