PET-NECK: a multicentre randomised Phase III non-inferiority trial comparing a positron emission tomography–computerised tomography-guided watch-and-wait policy with planned neck dissection in the management of locally advanced (N2/N3) nodal metastases in patients with squamous cell head and neck cancer

Autor: Hisham Mehanna, Chris C McConkey, Joy K Rahman, Wai-Lup Wong, Alison F Smith, Chris Nutting, Andrew GJ Hartley, Peter Hall, Claire Hulme, Dharmesh K Patel, Sandra Ventorin von Zeidler, Max Robinson, Bal Sanghera, Lydia Fresco, Janet A Dunn

Publikováno v: Health Technology Assessment, Vol 21, Iss 17 (2017)

Background: Planned neck dissection (ND) after radical chemoradiotherapy (CRT) for locally advanced nodal metastases in patients with head and neck squamous cell carcinoma (HNSCC) remains controversial. Thirty per cent of ND specimens show histologic

Externí odkaz: https://doaj.org/article/21485bece3b74ae9a85db80db20bc57c

PET-CT surveillance versus neck dissection in advanced head and neck cancer

Autor: Hisham, Mehanna, Wai-Lup, Wong, Christopher C, McConkey, Joy K, Rahman, Max, Robinson, Andrew G J, Hartley, Christopher, Nutting, Ned, Powell, Hoda, Al-Booz, Martin, Robinson, Elizabeth, Junor, Mohammed, Rizwanullah, Sandra V, von Zeidler, Hulya, Wieshmann, Claire, Hulme, Alison F, Smith, Peter, Hall, Janet, Dunn, Ashoke, Biswas

Publikováno v: Mehanna, H, Lup Wong, W, McConkey, C C, Rahman, J K, Robinson, M, Hartley, A G J, Nutting, C, Powell, N, Al-Booz, H, Robinson, M, Junor, E, Rizwanullah, M, Von Zeidler, S V, Wieshmann, H, Hulme, C, Smith, A F & Hall, P & Dunn, J 2016, ' PET-CT Surveillance versus Neck Dissection in Advanced Head and Neck Cancer ', New England Journal of Medicine, vol. 374, no. 15, pp. 1444-1454 . https://doi.org/10.1056/NEJMoa1514493

Background\ud \ud The role of image-guided surveillance as compared with planned neck dissection in the treatment of patients with squamous-cell carcinoma of the head and neck who have advanced nodal disease (stage N2 or N3) and who have received che

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8af66b8d81ed4d03464ed5d505a3e1f3
http://wrap.warwick.ac.uk/103397/1/WRAP-PET-CT-surveillance-versus-neck-dissection-Dunn-2016.pdf

Radiation Therapy Variation in the Randomized Phase 3 Positron Emission Tomography Neck Study

Autor: Joy K Rahman, M. Rizwanullah, Christopher M. Nutting, Elizabeth Junor, Andrew Hartley, Martin Robinson, Paul Sanghera, H. Al-Booz, Christopher C. McConkey, Charles Fong, Wai-Lup Wong, Janet A. Dunn, Hisham Mehanna

Publikováno v: International Journal of Radiation Oncology*Biology*Physics. 96:S117

Five hundred sixty-four patients with squamous cell carcinoma of the head and neck receiving definitive chemoradiation in the PET Neck phase 3 trial were randomized to either planned neck dissection or PETCT scan guided surveillance. The primary endp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d8ba3b022a158ccb8c062fd63408c8d5
https://doi.org/10.1016/j.ijrobp.2016.06.285

Is PET-CT guided management for patients with locally advanced head and neck squamous cell cancer (HNSCC) cost-effective? Results from a UK non-inferiority phase III randomized trial

Autor: Hisham Mehanna, Claire Hulme, Janet A. Dunn, Peter Hall, Alison Smith, Joy K Rahman, Christopher C. McConkey

Publikováno v: Journal of Clinical Oncology. 33:6010-6010

6010 Title: Despite ongoing controversy, planned node dissection (ND) remains a common treatment strategy after radical chemoradiotherapy (CRT) for locally advanced nodal metastases in patients wit...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3a606c0cc8a320fcb7db4202cd73b463
https://doi.org/10.1200/jco.2015.33.15_suppl.6010