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pro vyhledávání: '"Joy E. Garrett"'
Autor:
Pamela L Mendoza-Munoz, Navnath S Gavande, Pamela S VanderVere-Carozza, Katherine S Pawelczak, Joseph R Dynlacht, Joy E Garrett, John J Turchi
Publikováno v:
NAR Cancer. 5
The DNA-dependent protein kinase (DNA-PK) plays a critical role in the DNA damage response (DDR) and non-homologous end joining (NHEJ) double-strand break (DSB) repair pathways. Consequently, DNA-PK is a validated therapeutic target for cancer treatm
Abstract 2596: Impact of novel Ku-DNA binding inhibitors on the DNA DSBs-induced DNA damage response
Autor:
Pamela L. Mendoza-Munoz, Navnath S. Gavande, Pamela S. VanderVere-Carozza, Katherine S. Pawelczak, Joseph R. Dynlacht, Joy E. Garrett, John J. Turchi
Publikováno v:
Cancer Research. 82:2596-2596
The DNA-dependent protein kinase (DNA-PK) plays a critical role in the non-homologous end joining (NHEJ) double-strand break (DSB) repair pathway and the DNA damage response (DDR). Consequently, blocking DNA-PK kinase activity is a novel anti-cancer
Autor:
Joy E. Garrett, Erin Metzger, Katelyn Schmitt, Sarai Soto, Samantha Northern, Laura Kryah, Misbah Irfan, Susan Rice, Mary Brown, Jeffrey M. Zaleski, Joseph R. Dynlacht
Publikováno v:
Radiat Res
Enediyne natural products are a class of compounds that were recognized for their potential as chemotherapeutic agents many years ago, but found to be highly cytotoxic due to their propensity for low thermal activation. Bergman cyclization of the ene