Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Joy Drobnick"'
Autor:
Lucinda Tam, Annemarie Lekkerkerker, Jeffrey Eastham-Anderson, Melanie Domeyer, Brent S. McKenzie, Azadeh Hadadianpour, Eugene Varfolomeev, Arna Katewa, Steven Do, A. Francesca Setiadi, Wyne P. Lee, Joy Drobnick, Andres Paler-Martinez, Rajita Pappu, Katherine Bao, Marian C. Bryan, Alfred Wong, James J. Crawford, Cesar A. Corzo, Vida Asghari, Sha Klabunde, Vladimir Ramirez-Carrozi, Jodie Pang, Jason A. Hackney, Hans Brightbill, Christopher Dela Cruz, Ross Francis, Yonglian Sun, Merone Roose-Girma, Claire Emson, Wendy B. Young, Michael J. Townsend, James R. Kiefer, Cary D. Austin, Swathi Sujatha-Bhaskar, Emily Hunley, Nico Ghilardi, Daqi Xu, Søren Warming, Kate Senger, Zhiyu Huang, Vivian W. C. Lau, Domagoj Vucic, Ali A. Zarrin, Eric Suto
Publikováno v:
Science signaling. 13(634)
The dysregulation of multiple signaling pathways, including those through endosomal Toll-like receptors (TLRs), Fc gamma receptors (FcγR), and antigen receptors in B cells (BCR), promote an autoinflammatory loop in systemic lupus erythematosus (SLE)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6df56c99041e31c3d42be9d115b0561d
https://pubmed.ncbi.nlm.nih.gov/32487715
https://pubmed.ncbi.nlm.nih.gov/32487715
Autor:
Zhiyu Huang, Yingqing Ran, Le An, Alberto Gobbi, Jonathan Maher, Claire Emson, Naomi S. Rajapaksa, Edna F. Choo, Yongsheng Chen, Steven Do, Aleksandr Kolesnikov, Ali A. Zarrin, Christine Yu, Marian C. Bryan, Joy Drobnick, Swathi Sujatha-Bhaskar, Hans Brightbill, James R. Kiefer, Jun Liang, Brent S. McKenzie, Ross Francis, John S. Wai, Patrick J. Lupardus, Kevin DeMent
Publikováno v:
ACS Med Chem Lett
[Image: see text] IRAK4 kinase activity transduces signaling from multiple IL-1Rs and TLRs to regulate cytokines and chemokines implicated in inflammatory diseases. As such, there is high interest in identifying selective IRAK4 inhibitors for the tre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c741d6c5a8d5445e4411ce0bee8e8c5
https://europepmc.org/articles/PMC7073891/
https://europepmc.org/articles/PMC7073891/
Autor:
Patrick J. Lupardus, Yongsheng Chen, Naomi S. Rajapaksa, John S. Wai, Kevin DeMent, Edna F. Choo, Brent S. McKenzie, Ross Francis, Joy Drobnick, Hans Brightbill, James R. Kiefer, Willy M. Chang, Chudi Ndubaku, Alberto Gobbi, Antonio G. DiPasquale, Aleksandr Kolesnikov, Jonathan Maher, Jianwen Feng, Claire Emson, Le An, Ali A. Zarrin, Zhiyu Huang, Christine Yu, Yingqing Ran, Marian C. Bryan, Swathi Sujatha-Bhaskar
Publikováno v:
Journal of medicinal chemistry. 62(13)
A series of pyrazolopyrimidine inhibitors of IRAK4 were developed from a high-throughput screen (HTS). Modification of an HTS hit led to a series of bicyclic heterocycles with improved potency and kinase selectivity but lacking sufficient solubility
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0004b792a5f5c3e407829d184818a26
https://pubmed.ncbi.nlm.nih.gov/31082230
https://pubmed.ncbi.nlm.nih.gov/31082230
Autor:
Joy Drobnick, Kevin X. Chen, Amy Sambrone, Stephen Schmidt, Lan Wang, Tao Wang, Ping Wu, Jim Nonomiya, Jinhua Chen, Seth F. Harris, Stacey Yeung, Chudi Ndubaku, Zijin Xu, Stephen E. Gould, Huifen Chen, Terry Crawford, Weilan Ye, Tanya Smyczek, Jason Boggs, Rajiv Jesudason, Erin McNamara, Philip Vitorino, Ding Charles Z, Lesley J. Murray
Publikováno v:
ACS Medicinal Chemistry Letters. 6:913-918
Diverse biological roles for mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4) have necessitated the identification of potent inhibitors in order to study its function in various disease contexts. In particular, compounds that can be u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4691b6776a7f46441928aa91ff58247f
https://doi.org/10.1021/acsmedchemlett.5b00174
https://doi.org/10.1021/acsmedchemlett.5b00174
Autor:
Stephen Schmidt, Kevin R Clark, Joseph P. Lyssikatos, Brent A. Appleton, Joy Drobnick, Huifen Chen, Christian Wiesmann, Kerry Chapman, Jason Halladay, Ivana Yen, Ping Wu, Lewis J. Gazzard, Simon Charles Goodacre, Steve Sideris, Shiva Malek, Karen Williams
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:5704-5709
Checkpoint kinase 1 (ChK1) is activated in response to DNA damage, acting to temporarily block cell cycle progression and allow for DNA repair. It is envisaged that inhibition of ChK1 will sensitize tumor cells to treatment with DNA-damaging therapie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79ab92dabfac7006eb7c98b64e04605b
https://doi.org/10.1016/j.bmcl.2014.10.063
https://doi.org/10.1016/j.bmcl.2014.10.063
Publikováno v:
Tetrahedron. 70:1508-1515
A practical synthesis of α-haloaryl esters has been achieved via a chemoselective Negishi coupling of poly-halogenated aromatics and Reformatsky reagents in the presence of catalytic Pd(dba)2 and Xantphos. This chemistry tolerates a variety of aryl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7832ca71543e4896ce24b3e3562e556d
https://doi.org/10.1016/j.tet.2013.12.053
https://doi.org/10.1016/j.tet.2013.12.053
Autor:
Vickie Tsui, Paola Di Lello, James A. Ernst, Andy D. Tran, Yi Cao, Richard Pastor, Michael C. M. Kwok, Jeremy Murray, Ben Haley, Mark McCleland, Beth Blackwood, Trinna L. Cuellar, Jinfeng Liu, Till Maurer, David Stokoe, Chudi Ndubaku, Cuong Ly, Ingrid E. Wertz, Jake Drummond, Robert A. Blake, Sharon Yee, Lorna Kategaya, Joy Drobnick
Publikováno v:
Clinical Cancer Research. 23:B23-B23
Deubiquitinases (DUBs) are enzymes that proteolytically cleave ubiquitin from substrates. Substrates include oncogenes, tumor suppressors and polyubiquitinated proteins marked for degradation by the proteasome. Ubiquitin specific peptidase-7 (USP7) d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b0f471a855fab17c43de8138112dedb3
https://doi.org/10.1158/1557-3265.pmccavuln16-b23
https://doi.org/10.1158/1557-3265.pmccavuln16-b23
Autor:
Jennifer Epler, Joachim Rudolph, Joy Drobnick, Roxanne Vega, Ignacio Aliagas, Sreemathy Ramaswamy, Elizabeth Blackwood, Klaus P. Hoeflich, Diana Jakubiak, Wendy Lee, Haiming Zhang, Xianrui Zhao, Weiru Wang, Christopher E. Heise, David Favor, Chudi Ndubaku, Thomas W. O'Brien, Gary A. Cain, Lesley J. Murray, Paroma Chakravarty, Hank La, Christy C. Ong, Ping Dong, Connie Chan, James J. Crawford, Angela Oh, Yu Zhong, Dolores Díaz, Lewis J. Gazzard
Publikováno v:
Journal of medicinal chemistry. 59(11)
p21-activated kinase 1 (PAK1) has an important role in transducing signals in several oncogenic pathways. The concept of inhibiting this kinase has garnered significant interest over the past decade, particularly for targeting cancers associated with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0be5f9cfb402a0bbeedbcf126e00c2a
https://pubmed.ncbi.nlm.nih.gov/27167326
https://pubmed.ncbi.nlm.nih.gov/27167326
Autor:
Jeffrey Wallin, Jodie Pang, Laurent Salphati, Stephen E. Gould, Leslie Lee, Jonathan Cheong, Cristina Lewis, Timothy P. Heffron, Xiaolin Zhang, Steve Sideris, Chudi Ndubaku, Jim Nonomiya, Joy Drobnick, Emile Plise, Lan Wang, Bruno Alicke, Alan G. Olivero, Kyle A. Edgar, John Lesnick
Publikováno v:
ACS medicinal chemistry letters. 7(4)
Inhibition of phosphoinositide 3-kinase (PI3K) signaling is an appealing approach to treat brain tumors, especially glioblastoma multiforme (GBM). We previously disclosed our successful approach to prospectively design potent and blood–brain barrie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce007b2150b77e3550424574be811f9d
https://pubmed.ncbi.nlm.nih.gov/27096040
https://pubmed.ncbi.nlm.nih.gov/27096040
Autor:
Sreemathy Ramaswamy, Thomas O'Brien, Christopher E. Heise, Lesley J. Murray, Ignacio Aliagas, David A. Campbell, Laura M. Dornan, Ronen Marmorstein, Lewis J. Gazzard, Hank La, Diana Jakubiak, Baiwei Lin, Ping Dong, Weiru Wang, Jasna Maksimoska, Yu Zhong, James J. Crawford, Sergio G. Durón, Chudi Ndubaku, Wendy Lee, Angela Oh, Klaus P. Hoeflich, Xianrui Zhao, Joy Drobnick, Elizabeth Blackwood, Joseph P. Lyssikatos, Jennifer Epler, Joachim Rudolph
Publikováno v:
ACS medicinal chemistry letters. 6(12)
Signaling pathways intersecting with the p21-activated kinases (PAKs) play important roles in tumorigenesis and cancer progression. By recognizing that the limitations of FRAX1036 (1) were chiefly associated with the highly basic amine it contained,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1530afad83c5f3debd231a96a5626f91
https://pubmed.ncbi.nlm.nih.gov/26713112
https://pubmed.ncbi.nlm.nih.gov/26713112