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pro vyhledávání: '"Joy Creighton"'
Autor:
William G. Payne, Caden Schlund, Feng Wang, Joy Creighton, William P. Tansey, Jonathan David Macdonald, Edward T. Olejniczak, Jason Phan, Alex G. Waterson, Shaun R. Stauffer, Bin Zhao, J. Grace Shaw, Selena Chacón Simon, Lance R. Thomas, Stephen W. Fesik
Publikováno v:
Journal of Medicinal Chemistry. 63:4315-4333
The frequent deregulation of MYC and its elevated expression via multiple mechanisms drives cells to a tumorigenic state. Indeed, MYC is overexpressed in up to ∼50% of human cancers and is considered a highly validated anticancer target. Recently,
Autor:
Clare M. Adams, William P. Tansey, Joy Creighton, April M. Weissmiller, Qi Liu, Stephen W. Fesik, Lance R. Thomas, Christine M. Eischen, Shelly L. Lorey, Jing Wang
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance The oncoprotein transcription factor MYC is a validated but challenging anticancer target. In this work, we show that WDR5—a well-structured protein with druggable pockets—could be a focal point for effective anti-MYC therapies. We d