Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Joy A. Williams"'
Autor:
Joy A. Williams, Mark C. Udey, Stephen F. Porcella, Xi Chen, William E. Paul, Ilkka S. Junttila, Cedric Dewas, Jay T. Linton, Daniel E. Sturdevant, Tetsuya Honda, Lionel Feigenbaum, Lily Koo
Publikováno v:
The Journal of Immunology. 194:1372-1380
Thymic stromal lymphopoietin (TSLP) is a type I cytokine that plays a central role in induction of allergic inflammatory responses. Its principal targets have been reported to be dendritic cells and/or CD4 T cells; epithelial cells are a principal so
Publikováno v:
Crit Rev Immunol
Development and central tolerance of T lymphocytes in the thymus requires both TCR signals and collaboration with signals generated through costimulatory molecule interactions. In this review, we discuss the importance of CD28-CD80/86 and CD40-CD40L
Autor:
Joy A. Williams, Susan O. Sharrow, Hyein Jeon, Chiharu Fujihara, Richard J. Hodes, Masashi Watanabe
Publikováno v:
The Journal of Immunology. 193:5534-5544
Thymic development requires bidirectional interaction or cross-talk between developing T cells and thymic stromal cells, a relationship that has been best characterized for the interaction between thymocytes and thymic epithelial cells. We have chara
Autor:
Joy M. Williams, Preeti N. Malani, Andrew J. Haig, Patricia B. Mullan, Julie S. Perry, Rajesh S. Mangrulkar, Brent C. Williams, Joseph C. Kolars, Michelle Riba
Publikováno v:
Academic Medicine. 89:1153-1156
Problem Medical schools are challenged to realign curricula to address society's needs in a rapidly changing environment, and to support new instruction and assessment methods that require substantial faculty time. Approach In 2010, the University of
Autor:
Anthony J. Adams, Saulius Zuklys, S. Rhiannon Jenkinson, Larry Granger, Gail A. Bishop, Izumi Ohigashi, Joy A. Williams, Jingjing Zhang, Richard J. Hodes, Takeshi Nitta, Georg A. Holländer, Yongwon Choi, Yousuke Takahama, Susan O. Sharrow, Hyein Jeon, Michael J. Kruhlak, Ulrich Siebenlist
Publikováno v:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Induction of self-tolerance in developing T cells depends on medullary thymic epithelial cells (mTECs), whose development, in turn, requires signals from single-positive (SP) thymocytes. Thus, the absence of SP thymocytes in Tcra(-/-) mice results in
Publikováno v:
Annals of Global Health, Vol 82, Iss 3 (2016)
Autor:
Joy A. Williams, Ronald E. Gress, B A Heather Mella, Kirsten M. Williams, Philip J. Lucas, William G. Telford
Publikováno v:
Clinical and Translational Science. 2:279-285
Thymic epithelial cells (TECs) and dendritic cells are essential for the maintenance of thymopoiesis. Because these stromal elements define the progenitor niche, provide critical survival signals and growth factors, and direct positive and negative s
Publikováno v:
NeuroImage. 39:1142-1150
A troublesome source of physiological noise in functional magnetic resonance imaging (fMRI) is due to the spatio-temporal modulation of the magnetic field in the brain caused by normal subject respiration. fMRI data acquired using echo-planar imaging
Autor:
Karen S. Hathcock, James P. Allison, Joy A. Williams, Baishakhi Choudhury, David Klug, Yohsuke Harada, Ryo Abe, Richard J. Hodes
Publikováno v:
The Journal of Immunology. 175:4199-4207
Expression of CD28 is highly regulated during thymic development, with CD28 levels extremely low on immature thymocytes but increasing dramatically as CD4−CD8− cells initiate expression of TCRβ. B7-1 and B7-2, the ligands for CD28, have a restri
Publikováno v:
The Journal of Immunology. 170:781-787
The CD80/86-CD28 and CD40-CD40 ligand costimulatory pathways are essential for Th cell-dependent B cell responses that generate high-affinity, class-switched Ab in vivo. Disruption of either costimulatory pathway results in defective in vivo humoral