Functional neuromuscular junctions formed by embryonic stem cell-derived motor neurons.

Autor: Joy A Umbach, Katrina L Adams, Cameron B Gundersen, Bennett G Novitch

Publikováno v: PLoS ONE, Vol 7, Iss 5, p e36049 (2012)

A key objective of stem cell biology is to create physiologically relevant cells suitable for modeling disease pathologies in vitro. Much progress towards this goal has been made in the area of motor neuron (MN) disease through the development of met

Externí odkaz: https://doaj.org/article/25bf8d71cc134ced9b74f8fd1e4d1c17

Human embryonic stem cell-derived motor neurons expressing SOD1 mutants exhibit typical signs of motor neuron degeneration linked to ALS

Autor: Steven A. Goldman, Joy A. Umbach, Saravanan Karumbayaram, Harley I. Kornblum, Anne Roe, Theresa K. Kelly, Andrew Charles, Andres A. Paucar, Martina Wiedau-Pazos

Publikováno v: Disease Models & Mechanisms. 2:189-195

SUMMARY Human embryonic stem cell (hESC)-derived neurons have the potential to model neurodegenerative disorders. Here, we demonstrate the expression of a mutant gene, superoxide dismutase 1(SOD1), linked to familial amyotrophic lateral sclerosis (AL

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99ff83c93c23b10a8ae9d35f3b286108
https://doi.org/10.1242/dmm.002113

Lithium Ions Up-Regulate mRNAs Encoding Dense-Core Vesicle Proteins in Nerve Growth Factor-Differentiated PC12 Cells

Autor: Joy A. Umbach, Mara L. Cordeiro, Cameron B. Gundersen

Publikováno v: Journal of Neurochemistry. 75:2622-2625

We recently reported that lithium ions induced an up-regulation of cysteine string protein (CSP) gene expression in nerve growth factor (NGF)-differentiated PC12 cells but not in undifferentiated cells. Concomitantly, expression of two other proteins

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7068e7992aaaeb332be253ebbd9f050
https://doi.org/10.1046/j.1471-4159.2000.0752622.x

Foxp1-mediated programming of limb-innervating motor neurons from mouse and human embryonic stem cells

Autor: David Rousso, Katrina L. Adams, Bennett G. Novitch, Joy A. Umbach

Publikováno v: Nature communications, vol 6, iss 1
Nature Communications
Adams, KL; Rousso, DL; Umbach, JA; & Novitch, BG. (2015). Foxp1-mediated programming of limb-innervating motor neurons from mouse and human embryonic stem cells. Nature Communications, 6, 6778. doi: 10.1038/ncomms7778. UCLA: Retrieved from: http://www.escholarship.org/uc/item/19z2s5xf

Spinal motor neurons (MNs) control diverse motor tasks including respiration, posture and locomotion that are disrupted by neurodegenerative diseases such as amyotrophic lateral sclerosis and spinal muscular atrophy. Methods directing MN differentiat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a5b8217b86bb801ae2092c13205c12d
https://escholarship.org/uc/item/19z2s5xf

Glia of the Cholinergic Electromotor Nucleus of Torpedo Are the Source of the cDNA Encoding a GAT-1-Like GABA Transporter

Autor: Joy A. Umbach, Cameron B. Gundersen, Geoffrey T. Swanson

Publikováno v: Journal of Neurochemistry. 63:1-12

A PCR-based strategy was used to clone DNAs encoding Na(+)- and Cl(-)-dependent cotransport proteins using DNA from the cholinergic electromotor nucleus of Torpedo californica. This cloning strategy resulted in the isolation of a cDNA clone that show

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9c27ead95b96287da65af9f49771602
https://doi.org/10.1046/j.1471-4159.1994.63010001.x