Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Joy A McKenna"'
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Akademický článek
Transcriptional profiling links unique human macrophage phenotypes to the growth of intracellular Salmonella enterica serovar Typhi
Autor: Ruth Schade, Daniel S. C. Butler, Joy A. McKenna, Blanda Di Luccia, Vida Shokoohi, Meagan Hamblin, Trung H. M. Pham, Denise M. Monack
Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Macrophages provide a crucial environment for Salmonella enterica serovar Typhi (S. Typhi) to multiply during typhoid fever, yet our understanding of how human macrophages and S. Typhi interact remains limited. In this study, we delve into t
Externí odkaz: https://doaj.org/article/7d781e1ddeeb459c85e73c64d1e4b108
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2
Localized modulation of DNA supercoiling, triggered by the Shigella anti-silencer VirB, is sufficient to relieve H-NS-mediated silencing
Autor: Michael A Picker, Monika M A Karney, Taylor M Gerson, Alexander D Karabachev, Juan C Duhart, Joy A McKenna, Helen J Wing
Publikováno v: Nucleic Acids Research. 51:3679-3695
In Bacteria, nucleoid structuring proteins govern nucleoid dynamics and regulate transcription. In Shigella spp., at ≤30°C, the histone-like nucleoid structuring protein (H-NS) transcriptionally silences many genes on the large virulence plasmid.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3c11b6c3699f69989ca4c80479dae7b7
https://doi.org/10.1093/nar/gkad088
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3
Localized modulation of DNA supercoiling, triggered by the Shigella anti-silencer VirB, is sufficient to relieve H-NS-mediated silencing
Autor: Michael A. Picker, Monika M. A. Karney, Taylor M. Gerson, Alexander D. Karabachev, Juan C. Duhart, Joy A. McKenna, Helen J. Wing
Publikováno v: bioRxiv
In Bacteria, nucleoid structuring proteins govern nucleoid dynamics and regulate transcription. InShigella spp., at ≤ 30 °C, the histone-like nucleoid structuring protein (H-NS) transcriptionally silences many genes on the large virulence plasmid.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd9113c7b0215171ce09dad9b4e9d104
https://europepmc.org/articles/PMC9882051/
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4
The AraC/XylS Protein MxiE and Its Coregulator IpgC Control a Negative Feedback Loop in the Transcriptional Cascade That Regulates Type III Secretion in Shigella flexneri
Autor: Joy A. McKenna, Monika M. A. Karney, Daniel K. Chan, Natasha Weatherspoon-Griffin, Brianda Becerra Larios, M. Carolina Pilonieta, George P. Munson, Helen J. Wing
Publikováno v: J Bacteriol
Members of the AraC family of transcriptional regulators (AFTRs) control the expression of many genes important to cellular processes, including virulence. In Shigella species, the type III secretion system (T3SS), a key determinant for host cell inv
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c28483d0bcbc6d8bfc0719b03b330eb0
https://pubmed.ncbi.nlm.nih.gov/35703565
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6
The Antiactivator of Type III Secretion, OspD1, Is Transcriptionally Regulated by VirB and H-NS from Remote Sequences in Shigella flexneri
Autor: Joy A. McKenna, Helen J. Wing
Publikováno v: J Bacteriol
Shigella species, the causal agents of bacillary dysentery, use a type III secretion system (T3SS) to inject two waves of virulence proteins, known as effectors, into the colonic epithelium to subvert host cell machinery. Prior to host cell contact a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e8f1a66bdaa3042a911275d00aee8ab
https://doi.org/10.1128/jb.00072-20
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7
Investigating the DNA-Binding Site for VirB, a Key Transcriptional Regulator of Shigella Virulence Genes, Using an In Vivo Binding Tool
Autor: Natasha Weatherspoon-Griffin, Eliese A Potocek, Joy A. McKenna, Alexander D Karabachev, Monika Ma Karney, Helen J. Wing, Makensie E Millar
Publikováno v: Genes, Vol 10, Iss 2, p 149 (2019)
Genes
Volume 10
Issue 2
The transcriptional anti-silencing and DNA-binding protein, VirB, is essential for the virulence of Shigella species and, yet, sequences required for VirB-DNA binding are poorly understood. While a 7-8 bp VirB-binding site has been proposed, it was d
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46e1a4b009b08bfb1cc3e967a2e81974
https://www.mdpi.com/2073-4425/10/2/149
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8
Investigating the DNA-Binding Site for VirB, a Key Transcriptional Regulator of
Autor: Monika Ma, Karney, Joy A, McKenna, Natasha, Weatherspoon-Griffin, Alexander D, Karabachev, Makensie E, Millar, Eliese A, Potocek, Helen J, Wing
Publikováno v: Genes
The transcriptional anti-silencing and DNA-binding protein, VirB, is essential for the virulence of Shigella species and, yet, sequences required for VirB-DNA binding are poorly understood. While a 7-8 bp VirB-binding site has been proposed, it was d
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::18d9d21c6b07931f1c1e8f0b67011e46
https://pubmed.ncbi.nlm.nih.gov/30781432
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9
Overweight and Obese Low-Income Women: Restorative Health Behaviors Under Overwhelming Conditions
Autor: Susan W. Buchholz, Joy Christine McKenna, Dolores Huffman
Publikováno v: Health Care for Women International. 33:182-197
In this grounded theory study we used semistructured interviews to explore how 16 low-income uninsured Midwestern United States women who were overweight or obese felt about their condition. Using grounded theory, we identified a central problem-over
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a0fa7aecf9cb7419a36014c92ce77cf
https://doi.org/10.1080/07399332.2011.630115
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