Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Jowita Mikolajczyk"'
Autor:
Robert C. Liddington, Naran Gombosuren, Marcin Drag, Arnold C. Satterthwait, Alexander E. Aleshin, Guy S. Salvesen, Ge Wei, Alex Y. Strongin, Jowita Mikolajczyk
Publikováno v:
Journal of Biological Chemistry. 287:39470-39479
The K7L gene product of the smallpox virus is a protease implicated in the maturation of viral proteins. K7L belongs to protease Clan CE, which includes distantly related cysteine proteases from eukaryotes, pathogenic bacteria, and viruses. Here, we
Autor:
David H. Drewry, Eidarus Salah, Joel Morris, John P. Overington, Jowita Mikolajczyk, Francis Atkinson, Alexander Tropsha, Karen Lackey, Jonathan M. Elkins, Kamal R. Abdul Azeez, Mark Kunkel, Nikolai Sepetov, Daniel J. Price, Xi Ping Huang, Eric C. Polley, Timothy M. Willson, Beverly A. Teicher, Vita Fedele, Susanne Müller, Ayman Al Haj Zen, William J. Zuercher, Eugene N. Muratov, Sergei Romanov, Paul Bamborough, Bryan L. Roth, Stefan Knapp, Denis Fourches, M. Szklarz
Despite the success of protein kinase inhibitors as approved therapeutics, drug discovery has focused on a small subset of kinase targets. Here we provide a thorough characterization of the Published Kinase Inhibitor Set (PKIS), a set of 367 small-mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef3b54fff9b892e25076832396fb828f
Autor:
Amy J. Campbell, Victoria E. Albrow, James C. Powers, Elizabeth L. Ponder, Junpeng Xiao, Miklós Békés, Edgar Deu, Urša Pečar Fonović, Marcin Drag, Jowita Mikolajczyk, Brittany A. Leader, Matthew Bogyo, Aimee Shen, Guy S. Salvesen
Publikováno v:
Chemistry & Biology. 18:711-721
SummarySmall ubiquitin-related modifier (SUMO) is implicated in the regulation of numerous biological processes including transcription, protein localization, and cell cycle control. Protein modification by SUMO is found in Plasmodium falciparum; how
Autor:
Jowita Mikolajczyk, Mary Dasso, Marcin Drag, Keith D. Wilkinson, Nela Moffatt, Nagamalleswari Kolli, Debaditya Mukhopadhyay, Guy S. Salvesen
Publikováno v:
Biochemical Journal. 430:335-344
The covalent attachment of SUMO (small ubiquitin-like protein modifier) to target proteins results in modifications in their activity, binding interactions, localization or half-life. The reversal of this modification is catalysed by SENPs (SUMO-spec
Autor:
Jonathan A. Ellman, Marcin Drag, Miklós Békés, Francisca E. Reyes-Turcu, Keith D. Wilkinson, Guy S. Salvesen, Jowita Mikolajczyk
Publikováno v:
Biochemical Journal
DUBs (deubiquitinating enzymes) are a family of proteases responsible for the specific removal of ubiquitin attached to target proteins and thus control the free cellular pools of this molecule. DUB activity is usually assayed using full-length ubiqu
Publikováno v:
Biochemical Journal. 409:461-469
SENPs [Sentrin/SUMO (small ubiquitin-related modifier)-specific proteases] include proteases that activate the precursors of SUMOs, or deconjugate SUMOs attached to target proteins. SENPs are usually assayed on protein substrates, and for the first t
Publikováno v:
Journal of Biological Chemistry. 282:26217-26224
SENPs are proteases that participate in the regulation of SUMOylation by generating mature small ubiquitin-related modifiers (SUMO) for protein conjugation (endopeptidase activity) and removing conjugated SUMO from targets (isopeptidase activity). Us
Autor:
John C. Reed, Michael J. Duffy, Steven Banares, Hoguen Kim, David Marr, Jowita Mikolajczyk, Maryla Krajewska, Ahmed Shabaik, Yick Fu Wong, Xianshu Huang, Susan Kennedy, Hirad Hedayat, Ivo Meinhold-Heerlein, Stan Krajewski, Eunah Shin
Publikováno v:
Clinical Cancer Research. 11:5462-5471
Purpose: Caspase-14 is unique among caspase family proteases in that its proteolytic processing has been principally associated with epithelial cell differentiation rather than apoptosis or inflammation. We investigated caspase-14 expression in sever
Publikováno v:
Biochemistry. 43:10560-10569
Caspase-14 is a developmentally regulated and tissue restricted member of the caspase family present in mammals. It is mainly found in epidermal keratinocytes and has been hypothesized to be involved in a tissue-specific form of cell senescence, lead
Publikováno v:
Clinical Infectious Diseases. 28:456-465
It has been demonstrated that the Porphyromonas gingivalis cysteine proteinases (gingipains) activate and/or degrade a broad range of host proteins. Inactivation of gingipains R prior to infection of mice results in a decrease in the virulence of P.