A Latent Cardiomyocyte Regeneration Potential in Human Heart Disease.

Autor: Derks W; Centers for Regenerative Therapies Dresden, Technische Universität Dresden, Germany. (W.D., F.R., P.H., A.H., L.P., I.S., O.B.)., Rode J; Information Services and High-Performance Computing, Technische Universität Dresden, Germany. (J.R., F.R., L.B.)., Collin S; Department of Cell and Molecular Biology, Stockholm, Sweden. (S.C., E.L., E.G., J.F., O.B.)., Rost F; Centers for Regenerative Therapies Dresden, Technische Universität Dresden, Germany. (W.D., F.R., P.H., A.H., L.P., I.S., O.B.).; Information Services and High-Performance Computing, Technische Universität Dresden, Germany. (J.R., F.R., L.B.).; DRESDEN-Concept Genome Center, Technology Platform at the Center for Molecular and Cellular Bioengineering, Technische Universität Dresden, Germany. (F.R.)., Heinke P; Centers for Regenerative Therapies Dresden, Technische Universität Dresden, Germany. (W.D., F.R., P.H., A.H., L.P., I.S., O.B.)., Hariharan A; Centers for Regenerative Therapies Dresden, Technische Universität Dresden, Germany. (W.D., F.R., P.H., A.H., L.P., I.S., O.B.)., Pickel L; Centers for Regenerative Therapies Dresden, Technische Universität Dresden, Germany. (W.D., F.R., P.H., A.H., L.P., I.S., O.B.)., Simonova I; Centers for Regenerative Therapies Dresden, Technische Universität Dresden, Germany. (W.D., F.R., P.H., A.H., L.P., I.S., O.B.)., Lázár E; Department of Cell and Molecular Biology, Stockholm, Sweden. (S.C., E.L., E.G., J.F., O.B.)., Graham E; Department of Cell and Molecular Biology, Stockholm, Sweden. (S.C., E.L., E.G., J.F., O.B.)., Jashari R; European Homograft Bank, Brussels, Belgium (R.J.)., Andrä M; Department of Cardiothoracic and Vascular Surgery, Klinikum Klagenfurt and Section for Surgical Research Medical University Graz, Austria (M.A.)., Jeppsson A; Department of Cardiothoracic Surgery, Sahlgrenska University Hospital, Gothenburg, Sweden. (A.J.).; Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. (A.J.)., Salehpour M; Department of Physics and Astronomy, Applied Nuclear Physics, Uppsala University, Uppsala, Sweden (M.S.)., Alkass K; Department of Oncology-Pathology, Stockholm, Sweden. (K.A., H.D.).; Department of Karolinska Institute; and National Board of Forensic Medicine, Stockholm, Sweden. (K.A., H.D.)., Druid H; Department of Oncology-Pathology, Stockholm, Sweden. (K.A., H.D.).; Department of Karolinska Institute; and National Board of Forensic Medicine, Stockholm, Sweden. (K.A., H.D.)., Kyriakopoulos CP; Divisions of Cardiovascular Medicine and Cardiothoracic Surgery, University of Utah Health and School of Medicine, Salt Lake City. (C.P.K., I.T., C.H.S., S.D.).; Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City. (C.P.K., I.T., T.S.S., C.H.S., S.D.)., Taleb I; Divisions of Cardiovascular Medicine and Cardiothoracic Surgery, University of Utah Health and School of Medicine, Salt Lake City. (C.P.K., I.T., C.H.S., S.D.).; Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City. (C.P.K., I.T., T.S.S., C.H.S., S.D.)., Shankar TS; Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City. (C.P.K., I.T., T.S.S., C.H.S., S.D.)., Selzman CH; Divisions of Cardiovascular Medicine and Cardiothoracic Surgery, University of Utah Health and School of Medicine, Salt Lake City. (C.P.K., I.T., C.H.S., S.D.).; Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City. (C.P.K., I.T., T.S.S., C.H.S., S.D.)., Sadek H; Department of Internal Medicine; and Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas (H.S.)., Jovinge S; Spectrum Health Frederik Meijer Heart and Vascular Institute and Van Andel Institute, Grand Rapids, MI (S.J.)., Brusch L; Information Services and High-Performance Computing, Technische Universität Dresden, Germany. (J.R., F.R., L.B.)., Frisén J; Department of Cell and Molecular Biology, Stockholm, Sweden. (S.C., E.L., E.G., J.F., O.B.)., Drakos S; Divisions of Cardiovascular Medicine and Cardiothoracic Surgery, University of Utah Health and School of Medicine, Salt Lake City. (C.P.K., I.T., C.H.S., S.D.).; Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City. (C.P.K., I.T., T.S.S., C.H.S., S.D.)., Bergmann O; Centers for Regenerative Therapies Dresden, Technische Universität Dresden, Germany. (W.D., F.R., P.H., A.H., L.P., I.S., O.B.).; Department of Cell and Molecular Biology, Stockholm, Sweden. (S.C., E.L., E.G., J.F., O.B.).; Department of Pharmacology and Toxicology, University Medical Center Goettingen, Germany (O.B.).; DZHK (German Centre for Cardiovascular Research), Lower Saxony Partner Site (O.B.), Germany.

Publikováno v: Circulation [Circulation] 2024 Nov 21. Date of Electronic Publication: 2024 Nov 21.

A latent cardiomyocyte regeneration potential in human heart disease.

Autor: Derks W; Center for Regenerative Therapies Dresden, TU Dresden, Dresden, Germany., Rode J; Center of Information Services and High-Performance Computing, TU Dresden, Dresden, Germany., Collin S; Department of Cell and Molecular Biology, Karolinska Institute, SE-171 77 Stockholm, Sweden., Rost F; Center for Regenerative Therapies Dresden, TU Dresden, Dresden, Germany.; Center of Information Services and High-Performance Computing, TU Dresden, Dresden, Germany.; DRESDEN-concept Genome Center, Technology Platform at the Center for Molecular and Cellular Bioengineering (CMCB), Technische Universität Dresden, Dresden, Germany., Heinke P; Center for Regenerative Therapies Dresden, TU Dresden, Dresden, Germany., Hariharan A; Center for Regenerative Therapies Dresden, TU Dresden, Dresden, Germany., Pickel L; Center for Regenerative Therapies Dresden, TU Dresden, Dresden, Germany., Simonova I; Center for Regenerative Therapies Dresden, TU Dresden, Dresden, Germany., Lázár E; Department of Cell and Molecular Biology, Karolinska Institute, SE-171 77 Stockholm, Sweden., Graham E; Department of Cell and Molecular Biology, Karolinska Institute, SE-171 77 Stockholm, Sweden., Jashari R; European Homograft Bank, B-1120 Brussels, Belgium., Andrä M; Department of Cardiothoracic and Vascular Surgery, Klinikum Klagenfurt and Section for Surgical Research Medical University Graz, 9020 Graz, Austria., Jeppsson A; Department of Cardiothoracic Surgery, Sahlgrenska University Hospital, SE-413 45 Gothenburg, Sweden.; Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Salehpour M; Department of Physics and Astronomy, Applied Nuclear Physics, Uppsala University, SE-751 20 Uppsala, Sweden., Alkass K; Department of Oncology-Pathology, Karolinska Institute, SE-171 77 Stockholm and National Board of Forensic Medicine, SE-171 65 Stockholm, Sweden., Druid H; Department of Oncology-Pathology, Karolinska Institute, SE-171 77 Stockholm and National Board of Forensic Medicine, SE-171 65 Stockholm, Sweden., Kyriakopoulos CP; Divisions of Cardiovascular Medicine and Cardiothoracic Surgery, University of Utah Health & School of Medicine, Salt Lake City, Utah, United States.; Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, Utah, United States., Taleb I; Divisions of Cardiovascular Medicine and Cardiothoracic Surgery, University of Utah Health & School of Medicine, Salt Lake City, Utah, United States.; Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, Utah, United States., Shankar TS; Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, Utah, United States., Selzman CH; Divisions of Cardiovascular Medicine and Cardiothoracic Surgery, University of Utah Health & School of Medicine, Salt Lake City, Utah, United States.; Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, Utah, United States., Sadek H; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.; Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA., Jovinge S; Spectrum Health Frederik Meijer Heart & Vascular Institute and Van Andel Institute, Grand Rapids, MI 49503, USA., Brusch L; Center of Information Services and High-Performance Computing, TU Dresden, Dresden, Germany., Frisén J; Department of Cell and Molecular Biology, Karolinska Institute, SE-171 77 Stockholm, Sweden., Drakos S; Divisions of Cardiovascular Medicine and Cardiothoracic Surgery, University of Utah Health & School of Medicine, Salt Lake City, Utah, United States.; Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, Utah, United States., Bergmann O; Center for Regenerative Therapies Dresden, TU Dresden, Dresden, Germany.; Department of Cell and Molecular Biology, Karolinska Institute, SE-171 77 Stockholm, Sweden.; Pharmacology and Toxicology, Department of Pharmacology and Toxicology University Medical Center Goettingen, Goettingen, Germany.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Sep 17. Date of Electronic Publication: 2023 Sep 17.

Cholinergic regulation of vascular endothelial function by human ChAT ⁺ T cells.

Autor: Tarnawski L; Laboratory of Immunobiology, Division of Cardiovascular Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Solna, 171 76 Stockholm, Sweden., Shavva VS; Laboratory of Immunobiology, Division of Cardiovascular Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Solna, 171 76 Stockholm, Sweden., Kort EJ; DeVos Cardiovascular Program, Van Andel Research Institute and Fredrik Meijer Heart and Vascular Institute/Spectrum Health, Grand Rapids, MI 49503., Zhuge Z; Department of Physiology and Pharmacology, Karolinska Institutet, 171 77 Stockholm, Sweden., Nilsson I; Vascular Biology Division, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 65 Stockholm, Sweden., Gallina AL; Laboratory of Immunobiology, Division of Cardiovascular Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Solna, 171 76 Stockholm, Sweden., Martínez-Enguita D; Bioinformatics Division, Department of Physics, Chemistry and Biology, Linköping University, 581 83 Linköping, Sweden., Heller Sahlgren B; Vascular Biology Division, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 65 Stockholm, Sweden., Weiland M; DeVos Cardiovascular Program, Van Andel Research Institute and Fredrik Meijer Heart and Vascular Institute/Spectrum Health, Grand Rapids, MI 49503., Caravaca AS; Laboratory of Immunobiology, Division of Cardiovascular Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Solna, 171 76 Stockholm, Sweden., Schmidt S; Pronexus Analytical AB, Bromma, 167 33 Stockholm, Sweden., Chen P; Division of Clinical Chemistry, Department of Laboratory Medicine, Karolinska Institutet, 141 52 Stockholm, Sweden., Abbas K; Laboratory of Immunobiology, Division of Cardiovascular Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Solna, 171 76 Stockholm, Sweden., Wang FH; Pronexus Analytical AB, Bromma, 167 33 Stockholm, Sweden., Ahmed O; Laboratory of Immunobiology, Division of Cardiovascular Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Solna, 171 76 Stockholm, Sweden., Eberhardson M; Laboratory of Immunobiology, Division of Cardiovascular Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Solna, 171 76 Stockholm, Sweden.; Department of Health, Medicine and Caring Sciences, Linköping University, 581 83 Linköping, Sweden., Färnert A; Division of Infectious Diseases, Department of Medicine, Solna, Karolinska Institutet, Karolinska University Hospital, 171 76 Stockholm, Sweden., Weitzberg E; Department of Physiology and Pharmacology, Karolinska Institutet, 171 77 Stockholm, Sweden., Gustafsson M; Bioinformatics Division, Department of Physics, Chemistry and Biology, Linköping University, 581 83 Linköping, Sweden., Kehr J; Vascular Biology Division, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 65 Stockholm, Sweden.; Pronexus Analytical AB, Bromma, 167 33 Stockholm, Sweden., Malin SG; Laboratory of Immunobiology, Division of Cardiovascular Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Solna, 171 76 Stockholm, Sweden., Hult H; Department of Mathematics, KTH Royal Institute of Technology, 114 28 Stockholm, Sweden., Carlström M; Department of Physiology and Pharmacology, Karolinska Institutet, 171 77 Stockholm, Sweden., Jovinge S; DeVos Cardiovascular Program, Van Andel Research Institute and Fredrik Meijer Heart and Vascular Institute/Spectrum Health, Grand Rapids, MI 49503.; Cardiovascular Institute, Stanford University, Palo Alto, CA 94305., Olofsson PS; Laboratory of Immunobiology, Division of Cardiovascular Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Solna, 171 76 Stockholm, Sweden.; Institute of Bioelectronic Medicine, Feinstein Institutes for Medical Research, Manhasset, NY 11030.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2023 Apr 04; Vol. 120 (14), pp. e2212476120. Date of Electronic Publication: 2023 Mar 29.

Repurposing drugs to treat cardiovascular disease in the era of precision medicine.

Autor: Abdelsayed M; Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA.; Department of Medicine, Stanford University, Stanford, CA, USA., Kort EJ; DeVos Cardiovascular Program Spectrum Health & Van Andel Institute, Grand Rapids, MI, USA., Jovinge S; Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA. stefan.jovinge@skane.se.; DeVos Cardiovascular Program Spectrum Health & Van Andel Institute, Grand Rapids, MI, USA. stefan.jovinge@skane.se.; Department of Medicine, University of Texas Southwestern, Dallas, TX, USA. stefan.jovinge@skane.se.; Department of Clinical Sciences, Scania University Hospital, Lund University, Lund, Sweden. stefan.jovinge@skane.se., Mercola M; Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA. mmercola@stanford.edu.; Department of Medicine, Stanford University, Stanford, CA, USA. mmercola@stanford.edu.

Publikováno v: Nature reviews. Cardiology [Nat Rev Cardiol] 2022 Nov; Vol. 19 (11), pp. 751-764. Date of Electronic Publication: 2022 May 23.

Effect of Cyclosporine on Cytokine Production in Elective Coronary Artery Bypass Grafting: A Sub-Analysis of the CiPRICS (Cyclosporine to Protect Renal Function in Cardiac Surgery) Study.

Autor: Grins E; Department of Cardiothoracic Anesthesia and Intensive Care, Department of Clinical Sciences, Lund University, Skåne University Hospital, Lund, Sweden. Electronic address: Edgars.Grins@med.lu.se., Ederoth P; Department of Cardiothoracic Anesthesia and Intensive Care, Department of Clinical Sciences, Lund University, Skåne University Hospital, Lund, Sweden., Bjursten H; Department of Cardiothoracic Surgery, Department of Clinical Sciences Lund University, Skåne University Hospital, Lund, Sweden., Dardashti A; Department of Cardiothoracic Anesthesia and Intensive Care, Department of Clinical Sciences, Lund University, Skåne University Hospital, Lund, Sweden., Brondén B; Department of Cardiothoracic Anesthesia and Intensive Care, Department of Clinical Sciences, Lund University, Skåne University Hospital, Lund, Sweden., Metzsch C; Department of Cardiothoracic Anesthesia and Intensive Care, Department of Clinical Sciences, Lund University, Skåne University Hospital, Lund, Sweden., Erdling A; Department of Cardiothoracic Anesthesia and Intensive Care, Department of Clinical Sciences, Lund University, Skåne University Hospital, Lund, Sweden., Nozohoor S; Department of Cardiothoracic Surgery, Department of Clinical Sciences Lund University, Skåne University Hospital, Lund, Sweden., Mokhtari A; Department of Cardiothoracic Surgery, Department of Clinical Sciences Lund University, Skåne University Hospital, Lund, Sweden., Hansson MJ; Mitochondrial Medicine, Department of Clinical Sciences Lund, Lund University, Lund, Sweden., Elmér E; Mitochondrial Medicine, Department of Clinical Sciences Lund, Lund University, Lund, Sweden., Algotsson L; Department of Cardiothoracic Anesthesia and Intensive Care, Department of Clinical Sciences, Lund University, Skåne University Hospital, Lund, Sweden., Shrestha NM; DeVos Cardiovascular Research Program, Fredrik Meijer Heart and Vascular Institute Spectrum Health/Van Andel Institute, Grand Rapids, MI., Jovinge S; DeVos Cardiovascular Research Program, Fredrik Meijer Heart and Vascular Institute Spectrum Health/Van Andel Institute, Grand Rapids, MI; Cardiovascular Institute, Stanford University, Palo Alto, CA.

Publikováno v: Journal of cardiothoracic and vascular anesthesia [J Cardiothorac Vasc Anesth] 2022 Jul; Vol. 36 (7), pp. 1985-1994. Date of Electronic Publication: 2021 Nov 24.