Výsledky vyhledávání - "Jovanka Ravix"

Akademický článek

Calcium-Sensing Receptor Contributes to Hyperoxia Effects on Human Fetal Airway Smooth Muscle

Autor: Anne M. Roesler, Jovanka Ravix, Colleen M. Bartman, Brijeshkumar S. Patel, Marta Schiliro, Benjamin Roos, Lisa Nesbitt, Christina M. Pabelick, Richard J. Martin, Peter M. MacFarlane, Y. S. Prakash

Publikováno v: Frontiers in Physiology, Vol 12 (2021)

Supplemental O2 (hyperoxia), necessary for maintenance of oxygenation in premature infants, contributes to neonatal and pediatric airway diseases including asthma. Airway smooth muscle (ASM) is a key resident cell type, responding to hyperoxia with i

Externí odkaz: https://doaj.org/article/5535a7aeff7046d5bb61a44eac067e3e

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Class C GPCRs in the airway

Autor: Brijeshkumar S. Patel, Jovanka Ravix, Y. S. Prakash, Christina M. Pabelick

Publikováno v: Curr Opin Pharmacol

Understanding and targeting of GPCRs remains a critical aspect of airway pharmacology and therapeutics for diseases such as asthma or COPD. Most attention has been on the large Class A GPCRs towards improved bronchodilation and blunting of remodeling

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc86a8678a61aea0dc213f54cb204d1d
https://doi.org/10.1016/j.coph.2020.04.002

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Hyperoxia-induced Cellular Senescence in Fetal Airway Smooth Muscle Cells

Autor: Nathan K. LeBrasseur, L. Manlove, Pavan Parikh, Jovanka Ravix, Gary C. Sieck, A.M. Roesler, Sarah A. Wicher, Michael A. Thompson, R.D. Britt, Christina M. Pabelick, Daniel J. Tschumperlin, Y. S. Prakash, Jacob J. Teske, James L. Kirkland

Publikováno v: American Journal of Respiratory Cell and Molecular Biology

Supplemental O2 (hyperoxia; 30-90% O2) is a necessary intervention for premature infants, but it contributes to development of neonatal and pediatric asthma, necessitating better understanding of contributory mechanisms in hyperoxia-induced changes t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bb770be63acc63652268501bbc078a0
https://doi.org/10.1165/rcmb.2018-0176oc

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Calcium sensing receptor in developing human airway smooth muscle

Autor: Christina M. Pabelick, S.A. Wicher, Y. S. Prakash, Carol Farver, J.J. Teske, Peter M. MacFarlane, Jovanka Ravix, A.M. Roesler, Katelyn Cummings, Rodney D. Britt, Michael A. Thompson, L. Manlove

Publikováno v: J Cell Physiol

Airway smooth muscle (ASM) regulation of airway structure and contractility is critical in fetal/neonatal physiology in health and disease. Fetal lungs experience higher Ca(2+) environment which may impact on extracellular Ca(2+) ([Ca(2+)](o)) sensin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b02fa0c43a6d49ef630ff71da00a0a65
https://doi.org/10.1002/jcp.28115

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Development of human ectocervical tissue models with physiologic endocrine and paracrine signaling(†)

Autor: Rhitwika Sensharma, Jovanka Ravix, Teresa K. Woodruff, Kelly E. McKinnon, Spiro Getsios, Chloe Williams

Publikováno v: Biol Reprod

There is a shortage of research models that adequately represent the unique mucosal environment of human ectocervix, limiting development of new therapies for treating infertility, infection, or cancer. We developed three microphysiologic human ectoc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48246bfc45c9ea2143fd4b685e2a38bc
https://europepmc.org/articles/PMC7608514/

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YAP/TAZ are Activated by Mechanical and Hormonal Stimuli in Myometrium and Exhibit Increased Baseline Activation in Uterine Fibroids

Autor: Elizabeth A. Stewart, Mackenzie P. Purdy, Andrew J. Haak, Merrick T. Ducharme, Jovanka Ravix, Qi Tan, Delphine Sicard, Daniel J. Tschumperlin, Y. S. Prakash

Publikováno v: Reproductive sciences (Thousand Oaks, Calif.). 27(4)

Uterine fibroids (UFs) are benign myometrial neoplasms. The mechanical environment activates signaling through the Hippo pathway effectors Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding domain (TAZ) in other fibrotic di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89cc5ef0d8b111e77141e4cf0de4e929
https://pubmed.ncbi.nlm.nih.gov/32056132

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