The Staphylococcus aureus superantigen SElX is a bifunctional toxin that inhibits neutrophil function.

Autor: Stephen W Tuffs, David B A James, Jovanka Bestebroer, Amy C Richards, Mariya I Goncheva, Marie O'Shea, Bryan A Wee, Keun Seok Seo, Patrick M Schlievert, Andreas Lengeling, Jos A van Strijp, Victor J Torres, J Ross Fitzgerald

Publikováno v: PLoS Pathogens, Vol 13, Iss 9, p e1006461 (2017)

Bacterial superantigens (SAgs) cause Vβ-dependent T-cell proliferation leading to immune dysregulation associated with the pathogenesis of life-threatening infections such as toxic shock syndrome, and necrotizing pneumonia. Previously, we demonstrat

Externí odkaz: https://doaj.org/article/ae54e40195464ed8bfce66dbe8119856

Staphylococcal SSL5 Binding to Human Leukemia Cells Inhibits Cell Adhesion to Endothelial Cells and Platelets

Autor: Annemiek M. E. Walenkamp, Jovanka Bestebroer, Ingrid G. J. Boer, Roeline Kruizinga, Henk M. Verheul, Jos A. G. van Strijp, Carla J. C. de Haas

Publikováno v: Cellular Oncology, Vol 32, Iss 1-2, Pp 1-10 (2010)

Bacterial proteins provide promising tools for novel anticancer therapies. Staphylococcal superantigen-like 5 (SSL5) was recently described to bind P-selectin glycoprotein ligand-1 (PSGL-1) on leukocytes and to inhibit neutrophil rolling on a P-selec

Externí odkaz: https://doaj.org/article/3c1f01beeb614de3bc89c9e5571dfd8b

Staphylococcus aureusproteins SSL6 and SElX interact with neutrophil receptors as identified using secretome phage display

Autor: J. Ross Fitzgerald, Pieter-Jan A. Haas, Jovanka Bestebroer, Mirjam M. Mebius, Jos A. G. van Strijp, Cindy Fevre, Carla J. C. de Haas

Publikováno v: Cellular Microbiology. 16:1646-1665

Summary In order to cause colonization and invasive disease, pathogenic bacteria secrete proteins that modulate host immune defences. Identification and characterization of these proteins leads to a better understanding of the pathological pro- cesse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b8be4724d102fb63fb9547c8ba4fcc24
https://doi.org/10.1111/cmi.12313

The ESX-5 System of Pathogenic Mycobacteria Is Involved In Capsule Integrity and Virulence through Its Substrate PPE10

Autor: Nicole N. van der Wel, Gunny van Stempvoort, Massimiliano Maletta, Louis S. Ates, Juan J. Garcia-Vallejo, René J. P. Musters, Jovanka Bestebroer, Coenraad Kuijl, Daisy I. Picavet, Wilbert Bitter, Aniek D. van der Woude, Robert van de Weerd

Publikováno v: Ates, L S, van der Woude, A D, Bestebroer, J, van Stempvoort, G, Musters, R J P, Garcia-Vallejo, J J, Picavet, D I, van de Weerd, R, Maletta, M, Kuijl, C P, van der Wel, N N & Bitter, W 2016, ' The ESX-5 System of Pathogenic Mycobacteria Is Involved In Capsule Integrity and Virulence through Its Substrate PPE10 ', PLoS Pathogens, vol. 12, no. 6, 1005696 . https://doi.org/10.1371/journal.ppat.1005696
PLoS Pathogens
Plos Pathogens, 12(6):e1005696. Public Library of Science
PLoS pathogens, 12(6). Public Library of Science
PLoS Pathogens, 12(6):1005696. Public Library of Science
Ates, L S, van der Woude, A D, Bestebroer, J, van Stempvoort, G, Musters, R J, Garcia Vallejo, J J, Picavet, D I, van de Weerd, R, Maletta, M, Kuijl, C P, van der Wel, N N & Bitter, W 2016, ' The ESX-5 system of pathogenic mycobacteria is involved in capsule integrity and virulence through its substrate PPE10 ', Plos Pathogens, vol. 12, no. 6, e1005696 . https://doi.org/10.1371/journal.ppat.1005696
PLoS Pathogens, Vol 12, Iss 6, p e1005696 (2016)

Mycobacteria produce a capsule layer, which consists of glycan-like polysaccharides and a number of specific proteins. In this study, we show that, in slow-growing mycobacteria, the type VII secretion system ESX-5 plays a major role in the integrity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ae66ba1abe17b1d4c5e68493cc0f1e4
https://research.vumc.nl/en/publications/fdf810ea-d6e3-4eda-82bc-571b61e53aea

Functional basis for complement evasion by staphylococcal superantigen-like 7

Autor: Jovanka Bestebroer, Jörg Köhl, Jos A. G. van Strijp, Manoj K. Pandey, Carla J. C. de Haas, Suzan H.M. Rooijakkers, Piet C. Aerts

Publikováno v: Cellular Microbiology. 12:1506-1516

Summary The human pathogen Staphylococcus aureus has a plethora of virulence factors that promote its colonization and survival in the host. Among such immune modulators are staphylococcal superantigen-like (SSL) proteins, comprising a family of 14 s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5d5d66528b4697947aa593ea6f2b98a5
https://doi.org/10.1111/j.1462-5822.2010.01486.x