Anti-Parkinsonian and anti-dyskinetic profiles of two novel potent and selective nociceptin/orphanin FQ receptor agonists.

Autor: Arcuri L; Department of Medical Sciences, Section of Pharmacology, University of Ferrara, Ferrara, Italy.; Neuroscience Center and National Institute of Neuroscience, University of Ferrara, Ferrara, Italy., Novello S; Department of Medical Sciences, Section of Pharmacology, University of Ferrara, Ferrara, Italy.; Neuroscience Center and National Institute of Neuroscience, University of Ferrara, Ferrara, Italy., Frassineti M; Department of Medical Sciences, Section of Pharmacology, University of Ferrara, Ferrara, Italy.; Neuroscience Center and National Institute of Neuroscience, University of Ferrara, Ferrara, Italy., Mercatelli D; Department of Medical Sciences, Section of Pharmacology, University of Ferrara, Ferrara, Italy.; Neuroscience Center and National Institute of Neuroscience, University of Ferrara, Ferrara, Italy., Pisanò CA; Department of Medical Sciences, Section of Pharmacology, University of Ferrara, Ferrara, Italy.; Neuroscience Center and National Institute of Neuroscience, University of Ferrara, Ferrara, Italy., Morella I; Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, UK.; School of Biosciences, Cardiff University, Cardiff, UK., Fasano S; Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, UK.; School of Biosciences, Cardiff University, Cardiff, UK., Journigan BV; Astraea Therapeutics, Mountain View, CA, USA., Meyer ME; Astraea Therapeutics, Mountain View, CA, USA., Polgar WE; Astraea Therapeutics, Mountain View, CA, USA., Brambilla R; Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, UK.; School of Biosciences, Cardiff University, Cardiff, UK., Zaveri NT; Astraea Therapeutics, Mountain View, CA, USA., Morari M; Department of Medical Sciences, Section of Pharmacology, University of Ferrara, Ferrara, Italy.; Neuroscience Center and National Institute of Neuroscience, University of Ferrara, Ferrara, Italy.

Publikováno v: British journal of pharmacology [Br J Pharmacol] 2018 Mar; Vol. 175 (5), pp. 782-796. Date of Electronic Publication: 2018 Jan 31.

In vitro functional characterization of novel nociceptin/orphanin FQ receptor agonists in recombinant and native preparations.

Autor: Ferrari F; Section of Pharmacology, Department of Medical Sciences, and National Institute of Neurosciences, University of Ferrara, Italy., Cerlesi MC; Section of Pharmacology, Department of Medical Sciences, and National Institute of Neurosciences, University of Ferrara, Italy., Malfacini D; Section of Pharmacology, Department of Medical Sciences, and National Institute of Neurosciences, University of Ferrara, Italy., Asth L; Behavioral Pharmacology Laboratory, Department of Biophysics and Pharmacology, Federal University of Rio Grande do Norte, Natal, RN, Brazil., Gavioli EC; Behavioral Pharmacology Laboratory, Department of Biophysics and Pharmacology, Federal University of Rio Grande do Norte, Natal, RN, Brazil., Journigan BV; Astraea Therapeutics, LLC. 320 Logue Avenue, Mountain View, CA, USA., Kamakolanu UG; Astraea Therapeutics, LLC. 320 Logue Avenue, Mountain View, CA, USA., Meyer ME; Astraea Therapeutics, LLC. 320 Logue Avenue, Mountain View, CA, USA., Yasuda D; Astraea Therapeutics, LLC. 320 Logue Avenue, Mountain View, CA, USA., Polgar WE; SRI International, Biosciences Division, 333 Ravenswood Avenue, Menlo Park, CA, USA., Rizzi A; Section of Pharmacology, Department of Medical Sciences, and National Institute of Neurosciences, University of Ferrara, Italy., Guerrini R; Department of Chemical and Pharmaceutical Sciences and LTTA, University of Ferrara, Italy., Ruzza C; Section of Pharmacology, Department of Medical Sciences, and National Institute of Neurosciences, University of Ferrara, Italy., Zaveri NT; Astraea Therapeutics, LLC. 320 Logue Avenue, Mountain View, CA, USA., Calo G; Section of Pharmacology, Department of Medical Sciences, and National Institute of Neurosciences, University of Ferrara, Italy. Electronic address: g.calo@unife.it.

Publikováno v: European journal of pharmacology [Eur J Pharmacol] 2016 Dec 15; Vol. 793, pp. 1-13. Date of Electronic Publication: 2016 Oct 22.