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Strategies for Conditional Regulation of Proteins

Autor: Nadendla, Karthik, Simpson, Grant G, Becher, Julie, Journeaux, Toby, Cabeza-Cabrerizo, Mar, Bernardes, Gonçalo JL

Publikováno v: JACS Au. 3:344-357

Design of the next-generation of therapeutics, biosensors, and molecular tools for basic research requires that we bring protein activity under control. Each protein has unique properties, and therefore, it is critical to tailor the current technique

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a3d26e8b78aa9d8470e97cafe5f1d1f
https://doi.org/10.1021/jacsau.2c00654

Platform for Orthogonal N-Cysteine-Specific Protein Modification Enabled by Cyclopropenone Reagents

Autor: Istrate, Alena, Geeson, Michael B., Navo, Claudio D., Sousa, Barbara B., Marques, Marta C., Taylor, Ross J., Journeaux, Toby, Oehler, Sebastian R., Mortensen, Michael R., Deery, Michael J., Bond, Andrew D., Corzana, Francisco, Jiménez-Osés, Gonzalo, Bernardes, Gonçalo J. L., 0000-0002-9228-7947, 0000-0003-0161-412X, 0000-0003-4561-1828, 0000-0002-1744-0489, 0000-0001-5597-8127, 0000-0003-0105-4337, 0000-0001-6594-8917

Publikováno v: RIUR. Repositorio Institucional de la Universidad de La Rioja
instname
Journal of the American Chemical Society, 144 (23)

Protein conjugates are valuable tools for studying biological processes or producing therapeutics, such as antibody-drug conjugates. Despite the development of several protein conjugation strategies in recent years, the ability to modify one specific

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaa740cfe85dd76a13a1f924d2b40d43
https://investigacion.unirioja.es/documentos/62c9e7a6a405bc00e417fb39

Platform for Orthogonal N -Cysteine-Specific Protein Modification Enabled by Cyclopropenone Reagents.

Autor: Istrate A; Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW Cambridge, United Kingdom., Geeson MB; Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW Cambridge, United Kingdom., Navo CD; Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Building 800, 48160 Derio, Spain., Sousa BB; Instituto de Medicina Molecular, João Lobo Antunes, Faculdade de Medicina da Universidade de Lisboa, Av. Prof. Egas Moniz, 1649-028 Lisboa, Portugal., Marques MC; Instituto de Medicina Molecular, João Lobo Antunes, Faculdade de Medicina da Universidade de Lisboa, Av. Prof. Egas Moniz, 1649-028 Lisboa, Portugal., Taylor RJ; Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW Cambridge, United Kingdom., Journeaux T; Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW Cambridge, United Kingdom., Oehler SR; Department of Chemistry and Applied Biosciences, ETH Zürich, Vladimir-Prelog-Weg 3, 8093 Zürich, Switzerland., Mortensen MR; Department of Chemistry and Applied Biosciences, ETH Zürich, Vladimir-Prelog-Weg 3, 8093 Zürich, Switzerland., Deery MJ; Cambridge Centre for Proteomics, Gleeson Building, University of Cambridge, Tennis Court Road, CB2 1QR Cambridge, United Kingdom., Bond AD; Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW Cambridge, United Kingdom., Corzana F; Departamento de Química, Universidad de La Rioja, Centro de Investigación en Síntesis Química, 26006 Logroño, Spain., Jiménez-Osés G; Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Building 800, 48160 Derio, Spain.; Ikerbasque, Basque Foundation for Science, 48013 Bilbao, Spain., Bernardes GJL; Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW Cambridge, United Kingdom.; Instituto de Medicina Molecular, João Lobo Antunes, Faculdade de Medicina da Universidade de Lisboa, Av. Prof. Egas Moniz, 1649-028 Lisboa, Portugal.

Publikováno v: Journal of the American Chemical Society [J Am Chem Soc] 2022 Jun 15; Vol. 144 (23), pp. 10396-10406. Date of Electronic Publication: 2022 Jun 05.